Effect of Mori Folium Extract on Improvement of Blood Flow in Ferric Chloride-Induced Carotid Artery Damage Rat Model

강현주,; 전인화,; 권태오,; 최지원,; 김성주,; 장선일,

doi:10.15188/kjopp.2014.12.28.6.607

Cited by 1 publication

(1 citation statement)

References 21 publications

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“…In a previous study, HDL-cholesterol levels were higher in garlic shoot extract-treated groups than in a control group, whereas LDL-cholesterol and VLDL-cholesterol levels were lower, and the AI and CRF were significantly lower [ 31 ]. The AI is known as a risk indicator for coronary artery disease and CRF is known as a hyperlipidemia risk indicator [ 32 ]. In our study, the HDL-cholesterol, AI, and CRF values in the HFD + PO5% and the HFD + PO10% groups were significantly lower than those in the HFD group; therefore, administration of P. oleracea powder may be an effective measure to prevent cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Antiobesity and Antidiabetic Effects of Portulaca oleracea Powder Intake in High-Fat Diet-Induced Obese C57BL/6 Mice

Jung

Hwang

Park

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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This study investigated the hypothesis that Portulaca oleracea L. exerts antiobesity and antidiabetic effects by evaluating blood lipid profiles, blood glucose control factors, protein expression of lipid metabolism, and insulin sensitivity improvement. Three groups of high-fat diet (HFD) induced obese C57BL/6 mice (n = 8) received treatment with low (5%; HFD + PO5%) or high (10%; HFD + PO10%) concentrations of P. oleracea powder for 12 weeks or no treatment (HFD) and were compared with each other and a fourth control group. Weight gain was reduced by 34% in the HFD + PO10% group compared to the HFD group. Moreover, the perirenal and epididymal fat contents in the HFD + PO10% group were 6.3-fold and 1.5-fold, respectively, lower than those in the HFD group. The atherogenic index (AI) and cardiac risk factor (CRF) results in the P. oleracea-treated groups were significantly lower than those in the HFD group. The homeostasis model assessment of insulin resistance (HOMA-IR) levels was lower in the HFD + PO10% group than in the HFD group. The protein expression levels of the proliferator-activated receptor (PPAR)-α, glucose transporter (GLUT) 4 and PPAR-γ were upregulated in the HFD + PO10% group compared to the HFD group. However, the protein expression levels of tumor necrosis factor (TNF)-α were lower in the P. oleracea-treated groups than in the HFD group. Our results demonstrate that P. oleracea powder could be effectively used to treat and prevent obesity and diabetes-associated diseases through suppression of weight gain and reduction in body fat and blood glucose levels.

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Section: Discussionmentioning

confidence: 99%