Effect of Morinda officinalis capsule on osteoporosis in ovariectomized rats

Li, Ye; Lu, Shanshan; Tang, Guiying; Hou, Min; Tang, Qing; Zhang, Xiaona; Chen, Weihai; Chen, Gang; Xue, Qiang; Zhang, Congcong; Zhang, Jifen; Chen, Yi; Xu, Xiaoyu

doi:10.1016/s1875-5364(14)60034-0

Cited by 24 publications

(22 citation statements)

References 17 publications

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“…like compounds of plant origin such as phytoestrogens, have bone preserving effects following ovariectomy [7,8]. Phytoestrogens are comprised of isoflavones, lignans, coumestanes, flavonoids and stilbenes and they present structural and biological similarities with 17-β estradiol, as they can mimic or modulate the actions of endogenous estrogens in target organs by binding both alpha (ERα) and beta (ERβ) estrogen receptors [9].…”

Section: Introductionmentioning

confidence: 99%

The Protective Effect of Amphimas pterocarpoides Plant Extract on Bone Mineral Density and Strength in Estrogen Deficient Ovariectomized Wistar Rats

Patsaki¹,

Tchoumtchoua²,

Passali³

et al. 2016

Med Aromat Plants

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Section: Introductionmentioning

confidence: 99%

The Protective Effect of Amphimas pterocarpoides Plant Extract on Bone Mineral Density and Strength in Estrogen Deficient Ovariectomized Wistar Rats

Patsaki¹,

Tchoumtchoua²,

Passali³

et al. 2016

Med Aromat Plants

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“…Numerous research studies are currently focusing on the effects of traditional Chinese medicine (TCM) formulations on osteoporosis . However, pharmacological studies, especially those investigating the underlying mechanisms of TCM in DOP, are limited.…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese medicine Bushen‐Jianpi‐Huoxue decoction prevents diabetic osteoporosis in rats via Wnt and nuclear factor‐kappa B signaling pathways

Zhang¹,

Liu²,

Li³

et al. 2017

Int J of Rheum Dis

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“…XLGB capsule was officially approved by the Chinese State Food and Drug Administration (CFDA) as the over-the-counter (OTC) drug for treatment of osteoporosis, osteoarthritis, aseptic osteonecrosis and bone fracture [ 9 ]. As a phytoestrogen-rich TCM [ 11 ], preclinical studies showed that XLGB improved BMD and mechanical strength in ovariectomized (OVX) rats model [ 6 , 12 , 13 ] and prevented OVX-induced deterioration of hip in old rats [ 6 ]. Clinical data demonstrated its positive effects in promoting fracture healing [ 14 ] and treatment of osteoporosis [ 8 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

In Vivo Screening for Anti-Osteoporotic Fraction from Extract of Herbal Formula Xianlinggubao in Ovariectomized Mice

Wang

Guo

et al. 2015

PLoS ONE

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Background and ObjectivesTraditional Chinese Medicine (TCM) Fufang or formula Xianlinggubao (XLGB) is a prescribed TCM drug in China registered for prevention and treatment of osteoporosis. Fufang in TCM is comprised of a group of herbal compounds contributing in group to the treatment efficacy. The present study aims to identify the bioactive fraction(s) in XLGB extract that account(s) dominantly for its osteogenic effects.MethodsThe extract of XLGB formula was separated into three fractions using chromatography, i.e., XLGB-A, XLGB-B and XLGB-C. They were administrated to 4-month old ovariectomized (OVX) mice for 6 weeks to determine which bioactive fraction(s) were more effective for preventing OVX-induced bone loss evaluated by microCT, biomechanical testing and biochemical markers. The main peaks of the key fraction were identified using reference compounds isolated from the fraction. In addition, the effects of the composite compounds in XLGB-B on osteoblasts’ proliferation and mineralization were evaluated in UMR 106 cells.ResultsXLGB-B with a yield of 13.0% from herbal Fufang XLGB was identified as the most potential one among the three fractions for prevention of OVX-induced bone loss confirmed with bone mass, bone microarchitecture, bone strength and bone turnover markers. Nine compounds in HPLC fingerprint were identified in the XLGB-B fraction, including phenylpropanoids from Herba Epimedii, terpenes from Radix Dipsaci and coumarins from Fructus Psoraleae. In addition, the identified compounds effectively promoted proliferation and/or mineralization of osteoblast-like UMR 106 cells in vitro.ConclusionXLGB-B with defined phytochemical structures was screened as the key fraction that demonstrated preventive effects on OVX-induced bone loss in mice. The present study laid down a foundation towards a new generation of herbal Fufang characterized with “less herbal materials for achieving equal treatment efficacy” in development strategy of TCM for prevention of OVX-induced osteoporosis.

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Effect of Morinda officinalis capsule on osteoporosis in ovariectomized rats

Cited by 24 publications

References 17 publications

The Protective Effect of Amphimas pterocarpoides Plant Extract on Bone Mineral Density and Strength in Estrogen Deficient Ovariectomized Wistar Rats

The Protective Effect of Amphimas pterocarpoides Plant Extract on Bone Mineral Density and Strength in Estrogen Deficient Ovariectomized Wistar Rats

Traditional Chinese medicine Bushen‐Jianpi‐Huoxue decoction prevents diabetic osteoporosis in rats via Wnt and nuclear factor‐kappa B signaling pathways

In Vivo Screening for Anti-Osteoporotic Fraction from Extract of Herbal Formula Xianlinggubao in Ovariectomized Mice

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