Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats

Jaiswal, Dolly; Kumar, Prashant; Kumar, Amit; Mehta, Shikha; Watal, Geeta

doi:10.1016/j.jep.2009.03.036

Cited by 301 publications

(224 citation statements)

References 33 publications

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“…Inhibition of these enzymes has been adopted as dietary means for the control of postprandial hyperglycemia in diabetics. Reports have shown the use of moringa leaf in the management of diabetes (Jaiswal, Rai, Kumar, Mehta, & Watal, 2009), with its effect linked to the inhibition of carbohydrate hydrolyzing enzymes such α‐amylase and α‐glucosidase (Toma, Makonnen, Mekonnen, Debella, & Addisakwattana, 2014). However, there is dearth of information on how drying affects these properties.…”

Section: Discussionmentioning

confidence: 99%

Drying alters the phenolic constituents, antioxidant properties, α‐amylase, and α‐glucosidase inhibitory properties of Moringa (Moringa oleifera) leaf

Ademiluyi

Aladeselu

Oboh

et al. 2018

Food Science & Nutrition

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Moringa oleifera leaf is a popular green leafy vegetable which has found its usefulness in the preparation of traditional stews and soups. Like most green leafy vegetable which are not around year‐round, the leaf is usually dried and pulverized for storage and easier handling, and despite the popularity of this processing technique, there is dearth of information on how drying affects the health‐promoting properties of the leaves. Hence, this study sought to investigate the effect of some drying methods (freeze‐drying, sun, air and oven drying) on the phytoconstituents, antioxidant properties, and biological activities of moringa leaf. This study revealed that drying methods significantly altered the phytoconstituents (phenolics, flavonoids, vitamin C, tannin, saponin, phytate, oxalate, alkaloid, cardenolides, and cardiac glycosides), antioxidant capacities (reducing power, Fe2+chelating, ABTS •+, DPPH, and • OH scavenging abilities), and enzyme inhibitory (α‐amylase and α‐glucosidase) effects of the leaf, with freeze‐drying being the most promising method for preserving the nutraceutical properties of moringa leaf. However, for practical application, the order of preference of the drying methods which ensures adequate retention of phytoconstituents and possibly biological activities of the leaf as observed in this study is freeze‐drying > air drying > sun drying > oven drying, in the order of decreasing magnitude.

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Section: Discussionmentioning

confidence: 99%

Drying alters the phenolic constituents, antioxidant properties, α‐amylase, and α‐glucosidase inhibitory properties of Moringa (Moringa oleifera) leaf

Ademiluyi

Aladeselu

Oboh

et al. 2018

Food Science & Nutrition

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“…oleifera, of the monogeneric family Moringaceae, is distributed worldwide and has been known by a number of different names, including the horseradish tree (English), Soanjna (Hindi), Shobhanjana (Sanskrit), Saragvo (Gujarati), Sajna (Bengali), Munanga (Telugu) and Murangai (Tamil) (43). For millennia, various parts of M. oleifera have been used as nutritional supplements (as a rich source of vitamins A and C, iron, calcium, and protein) (44,45), and for their antibiotic (46)(47)(48)(49), antihyperlipidemic (50), antidiabetic (51,52), wound healing (53) and antiulcer properties (54). The edible parts of the plant have also been employed traditionally for skin diseases, rheumatism, anemia, cholera and other ailments (53).…”

Section: Discussionmentioning

confidence: 99%

A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells

2015

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Abstract. It has previously been reported that cold water-extracts of Moringa oleifera leaf have anticancer activity against various human cancer cell lines, including non-small cell lung cancer. In the present study, the anticancer activity of M. oleifera leaf extracts was investigated in human hepatocellular carcinoma HepG2 cells. By the analysis of apoptotic signals, including the induction of caspase or poly(ADP-ribose) polymerase cleavage, and the Annexin V and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assays, it was demonstrated that M. oleifera leaf extracts induce the apoptosis of HepG2 cells. In the hollow fiber assay, oral administration of the leaf extracts significantly reduced (44-52%) the proliferation of the HepG2 cells and A549 non-small cell lung cancer cells. These results support the potential of soluble extracts of M. oleifera leaf as orally administered therapeutics for the treatment of human liver and lung cancers.

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“…Currently, medicinal herbs as a whole were reported to be used against a wide range of health problems such as cough, cold, stomach, cataract, constipation and many other ailments [10].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Toxicity Effect of Graded Doses of Moringa oleifera Leaf Extract on Blood Indices Using 20 Adult Wistar Rats

N¹,

Asomugha²,

Asomugha³

et al. 2015

Int J of Biomed & Adv Res

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Epidemiological studies have indicated that Moringa oleifera leaves are a good source of nutrition and exhibit antioxidant activities. Moringa oleifera is being used for many medicinal and nutritional purposes, since it is widely consumed by all for nutritional and varying medicinal purposes; however there is limited scientific data available regarding excessive consumption of this plant. This study is carried out to evaluate the effect of Moringa oleifera leaf extract on some blood indices. 20 adult wistar rats were used for the study. They were divided into five groups (A, B, C, D & E) of four animals each. Group A served as the control and was orally administered distilled water; the experimental groups B, C, D, & E were orally administered different graded doses of Moringa oleifera leaf extract as follows 2000mg/kg, 3000mg/kg, 5000mg/kg and 7000mg/kg respectively for twenty one days. Twenty four hours after the last administration, blood samples for haematological analysis were collected through cardiac puncture into sterilized glass tubes containing ethylene diamine tetra acetic acid (EDTA) as anticoagulant. Packed cell volume estimation was done using microhaematocrit method. Sample dilution was done using Turk's fluid and cell count using improved neubauer counting chamber. Platelet count was estimated with ammonium oxalate and cell count using counting chamber. The result of this study suggests that excessive consumption of aqueous Moringa oleifera leaf extract may have little effect on blood parameters with slight changes in white blood cells.

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Effect of Moringa oleifera Lam. leaves aqueous extract therapy on hyperglycemic rats

Cited by 301 publications

References 33 publications

Drying alters the phenolic constituents, antioxidant properties, α‐amylase, and α‐glucosidase inhibitory properties of Moringa (Moringa oleifera) leaf

Drying alters the phenolic constituents, antioxidant properties, α‐amylase, and α‐glucosidase inhibitory properties of Moringa (Moringa oleifera) leaf

A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells

Evaluation of Toxicity Effect of Graded Doses of Moringa oleifera Leaf Extract on Blood Indices Using 20 Adult Wistar Rats

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