Effect of Moringa oleifera leaf extract on serum lipids and glycaemic control in alloxan induced diabetic albino rats

Oparinde, DP; Atiba, Adeniran Samuel; Ajose, O A; Eludoyin, A A; Adesiyan, Adekunle A.

doi:10.7439/ijbar.v5i10.887

Cited by 4 publications

(4 citation statements)

References 18 publications

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“…Interestingly, an increment of HDL was observed only in diabetic rats (40.4%), but in IR rats in which a decrement (10.3%) was observed. Similar results were obtained by other studies [ 141 ].…”

Section: Pharmacologysupporting

confidence: 93%

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Cultivation, Genetic, Ethnopharmacology, Phytochemistry and Pharmacology of Moringa oleifera Leaves: An Overview

Leone

Spada

Battezzati

et al. 2015

IJMS

618

483

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Moringa oleifera is an interesting plant for its use in bioactive compounds. In this manuscript, we review studies concerning the cultivation and production of moringa along with genetic diversity among different accessions and populations. Different methods of propagation, establishment and cultivation are discussed. Moringa oleifera shows diversity in many characters and extensive morphological variability, which may provide a resource for its improvement. Great genetic variability is present in the natural and cultivated accessions, but no collection of cultivated and wild accessions currently exists. A germplasm bank encompassing the genetic variability present in Moringa is needed to perform breeding programmes and develop elite varieties adapted to local conditions. Alimentary and medicinal uses of moringa are reviewed, alongside the production of biodiesel. Finally, being that the leaves are the most used part of the plant, their contents in terms of bioactive compounds and their pharmacological properties are discussed. Many studies conducted on cell lines and animals seem concordant in their support for these properties. However, there are still too few studies on humans to recommend Moringa leaves as medication in the prevention or treatment of diseases. Therefore, further studies on humans are recommended.

show abstract

Section: Pharmacologysupporting

confidence: 93%

“…Moringa oleifera treatment significantly increased the areas of positive purple modified Gomori stained β-cells (from 60% to 91%) and decreased the area percentage of collagen fibers (from 199% to 120%) compared to control values. All these findings were confirmed by other studies using similar approach [ 139 , 140 , 141 ].…”

Section: Pharmacologysupporting

confidence: 88%

Cultivation, Genetic, Ethnopharmacology, Phytochemistry and Pharmacology of Moringa oleifera Leaves: An Overview

Leone

Spada

Battezzati

et al. 2015

IJMS

618

483

View full text Add to dashboard Cite

show abstract

“…Insulin levels significantly increased, and HOMA-IR values have shown a significant reduction, which proved the potential of the extract to ameliorate insulin resistance (Tuorkey, 2016). Similar studies were conducted on Wistar rats, where reduction in the fasting blood glucose was observed (Babarinde et al, 2013;Ebenezer et al, 2019;Maiyaki-Musa et al, 2016;Oparinde et al, 2014). Histopathological findings reported that the extract restored pancreatic tissue integrity in the diabetic model when compared to standard drug glibenclamide (Maiyaki-Musa et al, 2016).…”

Section: Effect On Glycaemic Controlmentioning

confidence: 70%

“…This suggested a possibility that M. oleifera could be employed as a substitute for statins in large‐scale clinical trials and safety studies in future prospect. Further, in many in vivo studies, the aqueous leaf extract of M. oleifera established its varied potential in mitigating dyslipidemia and central obesity in drug and diet‐induced rodent models (Al‐Gebily et al, 2019; Irfan et al, 2020; Maiyaki‐Musa et al, 2016; Oparinde et al, 2014; Zeidan et al, 2019). The cumulative data suggested the use of aqueous extract as a dietary supplement for dyslipidemia and obesity.…”

Section: Effect On Dyslipidemia and Obesity (Abdominal Adiposity)mentioning

confidence: 99%

Moringa oleiferaLam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies

Adarthaiya,

Sehgal

2023

Phytotherapy Research

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The metabolic syndrome (MetS) refers to the co‐occurrence of risk factors, including hyperglycaemia, increased body weight, hypertension and dyslipidemia, which eventually lead to diabetes and cardiovascular disease, a common health problem worldwide. Recently, there has been an increasing interest in the use of plant‐based products for the management of MetS, because of their less detrimental and more beneficial effects. Moringa oleifera (Moringaceae), commonly known as drumstick, is cultivated worldwide for its nutritional and medicinal properties. This review focuses on the in vivo and human studies concerning the potential of M. oleifera in the alleviation of MetS and its comorbidities. The search for relevant articles was carried out in PubMed and Google Scholar databases. Randomised controlled and clinical trials from the PubMed database were included in this review. The results suggested that the administration of M. oleifera, in vivo, shows clear signs of improvement in MetS indices. Despite fewer human studies, the existing data documented convincing results that uphold the potential of M. oleifera against MetS. Therefore, future research discussing the probable mechanism of action is much needed which could further assure the usage of M. oleifera in the treatment regimen of MetS.

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تأثير زيت بذور المورينجا اوليفيرا في وقاية الکبد و خفض دهون الدم في الفئران المصابة بداء السکري

يوسف¹

2018

مجلة الاقتصاد المنزلي.جامعة المنوفية

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The present study has been conducted to estimate the influence of Moringa oleifera seeds oil in protection the liver and reduction of blood lipids in diabetic rats. Forty male rats were divided into four groups. Non-diabetic rats fed standard diet only (G1), non-diabetic rats fed standard diet + Moringa seeds oil (1.8 mg/kg) (G2), diabetic rats fed standard diet (G3) and diabetic rats fed standard diet + Moringa seeds oil (1.8 mg/kg) (G4). The study conducted for four weeks. The results showed that liver weight and relative liver weight were significantly increased in diabetic rats (G3) compared with (G1) and significantly decreased in diabetic rats treated with Moringa seeds oil (G4) compared with (G3). Treatment diabetic rats with Moringa seeds oil (G4) showed significantly reduction in serum glucose level comparing with nontreated diabetic rats (G3).The diabetic rats (G3) showed significantly elevation in levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), low-density lipoprotein (LDL), total cholesterol(CHOL) and significant decreased in high-density lipoprotein (HDL) compared with (G1). Diabetic rats treated with Moringa seeds oil (G4) showed a significant reduction in liver enzyme markers and improved in lipid profile parameters compared to non-treated diabetic rats (G3).The study concluded that Moringa seeds oil can be protect the liver and reduce blood lipids in diabetes. The potential mechanism of Moringa seeds oil in protection the liver possibly resulting from ability of free radical scavenging by antioxidants in the oil.

show abstract

Effect of Moringa oleifera leaf extract on serum lipids and glycaemic control in alloxan induced diabetic albino rats

Cited by 4 publications

References 18 publications

Cultivation, Genetic, Ethnopharmacology, Phytochemistry and Pharmacology of Moringa oleifera Leaves: An Overview

Cultivation, Genetic, Ethnopharmacology, Phytochemistry and Pharmacology of Moringa oleifera Leaves: An Overview

Moringa oleiferaLam. as a potential plant for alleviation of the metabolic syndrome—A narrative review based on in vivo and clinical studies

تأثير زيت بذور المورينجا اوليفيرا في وقاية الکبد و خفض دهون الدم في الفئران المصابة بداء السکري

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