Effect of mouse epidermal growth factor on plasma concentrations of LH, FSH and testosterone in rams

Brown, B. W.; Mattner, P. E.; Panaretto, BA; Brown, Garland

doi:10.1530/jrf.0.0870649

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…This growth factor has been shown to induce growth in skin, lung, tracheal, corneal, and gastrointestinal epithelium (38). Epidermal growth factor has also been shown to be important in the healing of gastric ulcers and surgical wounds and for maintaining the normal architecture of the intestine (39,40). …”

Section: Epidermal Growth Factormentioning

confidence: 99%

Growth factors: possible roles for clinical management of the short bowel syndrome

McMellen

Wakeman

Longshore

et al. 2010

Seminars in Pediatric Surgery

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The structural and functional changes during intestinal adaptation are necessary to compensate for the sudden loss of digestive and absorptive capacity after massive intestinal resection. When the adaptive response is inadequate, short bowel syndrome (SBS) ensues and patients are left with the requirement for parenteral nutrition and its associated morbidities. Several hormones have been studied as potential enhancers of the adaptation process. The effects of growth hormone (GH), insulin-like growth factor-1, epidermal growth factor and glucagon-like peptide-2 (GLP-2) on adaptation have been studied extensively in animal models. In addition, GH and GLP-2 have shown promise for the treatment of short bowel syndrome in clinical trials in humans. Several lesser studied hormones, including leptin, corticosteroids, thyroxine, testosterone and estradiol, are also discussed.

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Section: Epidermal Growth Factormentioning

confidence: 99%

Growth factors: possible roles for clinical management of the short bowel syndrome

McMellen

Wakeman

Longshore

et al. 2010

Seminars in Pediatric Surgery

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“…Specific induction of certain factors by certain hormones and different responses among various animal strains of the same species are possible (115). The SMG affects testicular function either by acting on the hypophysis or via EGF (116)(117)(118)(119)(120)(121). It also affects the uterus by the modulation of ovarian hormones (122).…”

Section: Endocrine Regulation Of Submandibular Gland Functionmentioning

confidence: 99%

Immunoregulation by the salivary glands

Sabbadini

Berczi

1998

Biomedical Reviews

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• The evidence for the integration of the submandibiilar gland (SMG) into the neuroimmiinoregulatory network is reviewed. In laboratory rodents, factors extracted from the SMG were shown to stimulate lymphocyte proliferation, to affect the weight of the thymus, spleen and lymph nodes and to induce immunosuppression in several in vivo and in vitro mo dels. The SMG produces significant amount of nerve growth factor (NGF), epidermal growth factor (EGF), transforming growth factor-/3, and kallikreins. These factors are secreted into the saliva and affect immune and mitcosal tissues and nerve endings in the gastrointestinal tract. They may thus play a role in the regulation of mucosal immune/inflammatory re sponses. The major salivary glands also produce antimicro bial proteins and secretory IgA antibodies which are essen tial factors in mucosal host defence. SMG-derivedNGF, EGF and glandular kallikrein are delivered into the bloodstream where they may act as important systemic immunoregulators and exert regulatory influences on the neuroendocrine system. Growth hormone, prolactin, androgens, thyroid hormone and corticosteroids regulate protein synthesis in the SMG, where as secretory activity is regulated by sympathetic, parasympathetic and peptidergic nerve fibres. Steroid hormones and cytokines as interleukin-la,-1(3 , tumor necrosis factor-a , interferon-y have major regulatory influence on protein secretion, including the secretion ofimmunoglobulin into the saliva. The SMG interacts with the mucosal and svstemic compartments of the immune system, with the central and

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Effect of mouse epidermal growth factor on fertility in rams

Brown¹,

Mattner²,

Panaretto³

et al. 1990

Aust. J. Agric. Res.

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Seminal characteristics and flock fertility were studied in Merino rams treated with mouse epidermal growth factor (EGF). Intravenous infusions of 105 8g EGF/kg body weight over 24 h in five rams had no statistically significant effect on daily sperm production measured from 6-10 weeks after dosing or on the percentages of spermatozoa that were unstained (nigrosinleosin stain) or morphologically normal. At 7-8 weeks post treatment, the percentage of spermatozoa exhibiting progressive motility was significantly reduced (P<0.05). By 9-10 weeks after treatment, the seminal characteristics were normal in all rams. In 1987, eight rams and in 1988, six ofthe same rams, were joined with ewes for 6 weeks (at a rate of 2%) 12 weeks after s.c. injection of 150 8g/kg body weight. Compared with the performance of control rams, EGF had no significant effect on ram fertility, nor did it produce any teratogenic effects in their progeny or effect their survival rate.

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Effect of mouse epidermal growth factor on plasma concentrations of LH, FSH and testosterone in rams

Cited by 6 publications

References 11 publications

Growth factors: possible roles for clinical management of the short bowel syndrome

Growth factors: possible roles for clinical management of the short bowel syndrome

Immunoregulation by the salivary glands

Effect of mouse epidermal growth factor on fertility in rams

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