1995
DOI: 10.1016/0006-8993(95)00391-3
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Effect of MPTP on dopaminergic neurons in the goldfish brain: a light and electron microscope study

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Cited by 36 publications
(24 citation statements)
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“…Meperidine derivative (MPTP) causes a Parkinsonian syndrome in humans and primates by altering or destroying mesostriatal dopaminergic neurons (Pollard et al, 1996). MPTP administered to goldfish also elicits a Parkinsonian syndrome, consisting of marked behavioural and neurochemical changes in the telencephalon that closely parallel observations in tetrapods (Goping et al, 1995;Pollard et al, 1996). Ocular abnormalities that occur in Parkinson's syndrome can also be induced in fish by altering dopaminergic neurotransmission (Dietrich et al, 2002).…”
Section: Dopaminergic Systemsmentioning
confidence: 94%
“…Meperidine derivative (MPTP) causes a Parkinsonian syndrome in humans and primates by altering or destroying mesostriatal dopaminergic neurons (Pollard et al, 1996). MPTP administered to goldfish also elicits a Parkinsonian syndrome, consisting of marked behavioural and neurochemical changes in the telencephalon that closely parallel observations in tetrapods (Goping et al, 1995;Pollard et al, 1996). Ocular abnormalities that occur in Parkinson's syndrome can also be induced in fish by altering dopaminergic neurotransmission (Dietrich et al, 2002).…”
Section: Dopaminergic Systemsmentioning
confidence: 94%
“…In the latter, the absence of these groups of cells has led to the search for cell groups that are homologous but located elsewhere in the teleost brain. Two such areas have been proposed, the catecholaminergic cells in the ventral telencephalon and the cells of the nucleus tuberis posterioris (TP), localised in the diencephalic posterior tuberculum (reviewed in Meek, 1994;and Reiner et al, 1998; but also see Goping et al, 1995;Pollard et al, 1996;Pombal et al, 1997). When the segmental development of the vertebrate rostral brain is taken into account (Puelles and Medina, 1994;Puelles and Verney, 1998;review in Reiner et al, 1998), the dopamine-positive cells of the substantia nigra and ventral tegmental area arise from a ventral territory that is primarily diencephalic and secondarily migrate into the ventral mesencephalon.…”
Section: Tissue-specific Expression Of the D 1 Receptor Subtypes And mentioning
confidence: 99%
“…After fixation, pellets were washed three or four times in 0.1 M cacodylate buffer. The first group was postfixed in 1% OsO 4 in 0.1 M cacodylate buffer, 1% K 3 Fe(CN) 6 to improve membrane contrast (Goping et al 1995), and 1% sucrose. The second group was incubated in buffer containing only 1% sucrose in 0.1 M cacodylate buffer for labeling with the TUNEL-based assay.…”
Section: Preparation Of Lr White Sectionsmentioning
confidence: 99%