Effect of multi-strain probiotic (UB0316) in weight management in overweight/obese adults: a 12-week double blind, randomised, placebo-controlled study

Abstract

This clinical trial was carried out to assess the effects of multi-strain probiotic capsule (UB0316: Lactobacillus salivarius UBLS-22, Lactobacillus casei UBLC-42, Lactobacillus plantarum, UBLP-40, Lactobacillus acidophilus UBLA-34, Bifidobacterium breve UBBr-01, Bacillus coagulans Unique IS2 5×109 cfu each and fructo-oligosaccharide, 100 mg) on overweight/obesity-related parameters. Ninety subjects (age, 30-65 years; body mass index (BMI), 25-32 kg/m2) were randomised into two groups, i.e. UB0316 (probiotic) and placebo (excipient maltodextrin). They were instructed to take 2 capsules (UB0316 or placebo) per day after meals for 12 weeks. Primary (BMI), and secondary (waist-to-hip ratio: WHR; body weight, body fat; sugar and lipid profile) endpoint measures were evaluated at scheduled visits. Vital signs, physical investigations, quality of life, physician/subjects global assessment and adverse events were also recorded. A total of 71 subjects completed the scheduled study visits and analysis thereof showed that a 12-week UB0316 supplementation significantly reduced BMI (95% CI: -0.64, -0.27; P=0.0001), body weight (95% CI: -1.16, -0.50; P<0.0001), and WHR (95% CI: -0.06, -0.01; P=0.007) from the baseline, compared to placebo. Fat, blood lipid and sugar profile changes were non-significant. UB0316 significantly improved quality of life of overweight/obese individuals. Furthermore, no severe adverse events or abnormal findings were noted during vital, blood and physical examinations. In conclusion, this 12-week trial demonstrates that UB0316 is effective in reducing BMI, body weight and WHR in overweight/obese adults.

Acceptability and Feasibility of a 13-Week Pilot Randomised Controlled Trial Testing the Effects of Incremental Doses of Beetroot Juice in Overweight and Obese Older Adults

“…While the recruitment target was met, 19% of the participants did not complete the trial. Losses to follow-up are common in long-term dietary interventions and other studies have reported attrition rates of up to 21% in a 12-week intervention study [27]. The 3month duration of our trial appeared to impact the attrition rate, as some participants found it difficult to maintain their adherence to the intervention for such a prolonged period.…”

Probiotic Strains and Intervention Total Doses for Modulating Obesity-Related Microbiota Dysbiosis: A Systematic Review and Meta-analysis

“…There is an exponential increase in the attention paid to the potential modulation of gut dysbiotic microbiota through dietary probiotics supplementation to prevent and/or improve metabolic diseases, such as obesity, diabetes, metabolic syndrome, and their comorbidities [ 62 , 63 , 64 ]. On the one hand, the use of the specific probiotic supplementation formulas was well substantiated through activity results in modifying key clinical biomarkers and safety demonstration [ 41 , 46 , 50 ].…”

Health-Promoting Role of Lactiplantibacillus plantarum Isolated from Fermented Foods

“…In line with the potential probiotic impact on metabolic syndrome, multistrain probiotic formulation UB0316, containing Lpb. plantarum UBLP-40, was recently applied as therapeutic intervention in patients affected by type-2 diabetes mellitus [190] and in a weight management clinical study [191].…”