Effect of Multiple Exposures of Low-Level Laser Therapy on the Cellular Responses of Wounded Human Skin Fibroblasts

Hawkins, Denise; Abrahamse, Heidi

doi:10.1089/pho.2006.24.705

Cited by 245 publications

(140 citation statements)

References 26 publications

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“…LLLT can also induce collagen synthesis and growth factor secretion. Furthermore, there is also a downregulation of the production of pro-inflammatory cytokines and cell apoptosis by LLLT [14][15][16][17][18][19][20].…”

Section: Lllt-mechanism Of Action On Cellular and Tissular Levelmentioning

confidence: 99%

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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Breast cancer is the most common cancer in women worldwide, with an incidence of 1.7 million in 2012. Breast cancer and its treatments can bring along serious side effects such as fatigue, skin toxicity, lymphedema, pain, nausea, etc. These can substantially affect the patients' quality of life. Therefore, supportive care for breast cancer patients is an essential mainstay in the treatment. Low-level light therapy (LLLT) also named photobiomodulation therapy (PBMT) has proven its efficiency in general medicine for already more than 40 years. It is a noninvasive treatment option used to stimulate wound healing and reduce inflammation, edema, and pain. LLLT is used in different medical settings ranging from dermatology, physiotherapy, and neurology to dentistry. Since the last twenty years, LLLT is becoming a new treatment modality in supportive care for breast cancer. For this review, all existing literature concerning the use of LLLT for breast cancer was used to provide evidence in the following domains: oral mucositis (OM), radiodermatitis (RD), lymphedema, chemotherapy-induced peripheral neuropathy (CIPN), and osteonecrosis of the jaw (ONJ). The findings of this review suggest that LLLT is a promising option for the management of breast cancer treatment-related side effects. However, it still remains important to define appropriate treatment and irradiation parameters for each condition in order to ensure the effectiveness of LLLT.

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Section: Lllt-mechanism Of Action On Cellular and Tissular Levelmentioning

confidence: 99%

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

et al. 2016

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“…Afirma-se que quando a dose ultrapassa esse limiar, o grau de atividade biológica celular também aumenta. Quando a dose aumenta demais, nenhum aumento na atividade celular pode ser observado, ou pode ser verificada ainda uma inibição da atividade 8 .…”

Section: Discussão Discussão Discussão Discussão Discussãounclassified

Ação da laserterapia no processo de proliferação e diferenciação celular: revisão da literatura

Henriques

Cazal

Castro

2010

Rev. Col. Bras. Cir.

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O uso da luz laser de baixa intensidade vem sendo utilizado como terapia coadjuvante ou de forma terapêutica isolada em várias especialidades odontológicas. Suas principais indicações incluem ação anti-inflamatória, analgésica e indutora da reparação tecidual. O poder cicatrizante do laser de baixa potência é discutido neste trabalho assim como os mecanismos de biomodulação e estimulação da mitose. Estas propriedades, já estudadas em células benignas, quando aplicadas em células neoplásicas malignas, abrem espaço para discussões. O objetivo do presente trabalho foi realizar uma revisão da literatura sobre os aspectos indutivos do laser no processo de proliferação celular principalmente no que se refere a estes mecanismos em células neoplásicas malignas.

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“…[12][13][14] Finally, these changes will lead to increased expression of growth factors and cell proliferation. 18,19 Furthermore, the most important intracellular organelle that produces reactive oxygen species (ROS) is the mitochondria. ROS is a natural by-product of electron transport chain activity.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of 660 nm Low-Level Laser and Light Emitted Diode in Proliferative Effects of Fibroblast Cells

et al. 2017

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Introduction: In recent years, low-power lasers have been widely used in medicine. With the introduction of affordable light emitted diode (LED), clinical application of LED light has become more and more popular. However, some researchers believe that due to lack of coherence of the LED light, it can be different in terms of biological effects, in comparison with laser. In this study, the biological effects of low-level laser (LLL) to those of LED light are compared and discussed. Methods: Human skin fibroblast cell line Hu02 was irradiated with LLL and LED light with a wavelength of 660 nm, power output of 35 mW and in continuous mode and the control group was not irradiated. The biological effects were compared through analysis of cell proliferation, production of reactive oxygen species (ROS) within the cell and rate of cell division. Results: Our findings showed that production of ROS within the cell was linearly increased both in the LED and laser light irradiated cells. However, laser light is more incremental in comparison to LED light. The MTT results showed that laser light at low energy density (less than 5 J/cm 2 ) increased the rate of cell proliferation after 24 hours. Although, the rate of cell division was increased in energy density of 1 J/cm 2 compared to the control group, this increase was not statistically significant. Discussion: The findings indicated that the coherence properties of laser light provided more energy for the cells, and in a constant energy density, laser light created more oxidative stresses in comparison with LED light.

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Effect of Multiple Exposures of Low-Level Laser Therapy on the Cellular Responses of Wounded Human Skin Fibroblasts

Cited by 245 publications

References 26 publications

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

The use of low-level light therapy in supportive care for patients with breast cancer: review of the literature

Ação da laserterapia no processo de proliferação e diferenciação celular: revisão da literatura

A Comparative Study of 660 nm Low-Level Laser and Light Emitted Diode in Proliferative Effects of Fibroblast Cells

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