Effect of multipurpose care solutions upon physical dimensions of silicone hydrogel contact lenses

Abstract

Interactions between contact lens multipurpose solution (MPS) components and the contact lenses with which they are used are both lens and solution dependent. As such, lens dimensional changes may arise after cleaning and immersion cycling in different lens care solutions over different time courses. In this study, the dimensional stability of five planned-replacement silicone hydrogel lenses (lotrafilcon B, comfilcon A, senofilcon A, senofilcon C, and samfilcon A) over 30 cycles in three different MPSs (Biotrue, OPTI-FREE Express, and OPTI-FREE Puremoist) was evaluated. Measurements of diameter, sagittal depth, power, roundness, and center thickness were obtained prior to, during, and after 30 cycles of cleaning and storage. Diameters of all lenses increased when soaked in Express or Biotrue but held the International Standards Organization (ISO) tolerance over the full course of 30 disinfection cycles; however, the diameters of comfilcon A, senofilcon A, senofilcon C, and samfilcon A lenses soaked in Puremoist exceeded ISO tolerance after between 4 and 9 immersion cycles. In contrast, the diameter of lotrafilcon B held tolerance. Similarly, all lenses cycled in Express or Biotrue held tolerance for sagittal depth, while in Puremoist only lotrafilcon B held tolerance. All lenses became less round in all MPSs but held tolerance for both power and central thickness. Given the lack of reported clinical issues with Puremoist when used with lenses other than lotrafilcon B, we propose that it may be appropriate to revisit the ISO test methods and tolerances to determine if they are still applicable for silicone hydrogel lenses. K E Y W O R D S ISO, lens care, lens-solution compatibility, multipurpose solution (MPS)

Interactions between contact lenses and lens care solutions: Influence in optical properties

“…It is expected that, after storage, CL dimensions would change due to the permeability of the polymer. This assumption was recently investigated by Smith and coworkers [24], who confirmed these changes, with LCS primary influence on CL diameter.…”

“…Nowadays, there is evidence that uptake and release of lens care solutions (LCS) components in CL materials may occur [21]. Differences in physical properties of solutions have been reported [22] that can induce different changes in CL properties, including from an optical point of view [23] or in their physical dimensions [24]. The main optical characteristics of contact lenses are related to its transparency and the ability to block ultraviolet radiation (UVR).…”

BCLA CLEAR - Evidence-based contact lens practice

“…High water ionic or early generation silicone hydrogel lens materials benefit from solutions with enhanced wetting agents, as may patients with dry eye, ocular surface disease or who report contact lens discomfort [451]. Clinicians should also be aware that lens parameters may be affected through cleaning and immersion of lenses in some contact lens solutions [452].…”

Advanced morphological analysis of siloxane‐hydrogel contact lenses

“…Several research reports have been published for the development of the siloxane‐hydrogel CLs with improved biocompatibility (Dupre & Benjamin, 2019; Dutta et al, 2018; Jacob, 2013; Kocela, Filipecki, Korzekwa, & Golis, 2012; Yasuda, 2006). Many clinical and retrospective studies demonstrated that different multipurpose solutions (MPS) developed for cleaning and disinfection of silicone‐hydrogel CLs are more biocompatible than others (Gorbet & Postnikoff, 2013; Lau, So, Chiang, & Cho, 2016; Lee et al, 2017; Smith, Zhu, Pierre, Gilbert, & Chinn, 2020; Zhang et al, 2017).…”