Effect of mutation on maternal–fetal metabolic homeostasis: general concepts

Stacey, T. E.

doi:10.1016/b978-0-407-02312-3.50015-6

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1988

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“…Shunting of blood flows within the placenta is insufficient to explain these low clearances (Faber & Thornburg, 1983a). They are more likely to reflect a barrier to passive diffusion, a concept for which there is now considerable circumstantial and experimental evidence in several species (Stacey, 1985). While the presence of such a barrier has the advantage of allowing some independent fetal homeostasis it may restrict the transfer of nutrients and waste products between mother and fetus.…”

Section: Discussionmentioning

confidence: 99%

In vivo permeability of the human placenta to inulin and mannitol.

Bain¹,

Copas²,

Landon³

et al. 1988

The Journal of Physiology

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SUMMARY1. Permeability of the term human placenta to inulin and mannitol was measured in six normal pregnancies.2. Bolus and continuous infusion of inulin and mannitol to the mother for 1-2 h before delivery by Caesarean section achieved steady-state maternal serum concentrations. Net accumulation of inulin and mannitol in the fetus was measured by the subsequent neonatal urinary excretion.3. Transplacental clearance was calculated by dividing the net flux by the time-averaged transplacental concentration gradient. Clearance for inulin was 0-86+0-1 ml min-' (mean+s.E.M.) and for mannitol 7-3+0 8 ml min-' (n = 6 in both cases).

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Section: Discussionmentioning

confidence: 99%