Effect of Myopia Severity on the Health-Related Quality of Life in Children and Their Parents

Objectives To investigate the longitudinal changes of refraction and visual acuity in children with early-onset high myopia (eoHM). Methods We retrospectively included children with eoHM, defined as cycloplegic spherical equivalent (SE) ≤ − 6.00 D or axial length (AL) ≥ 26mm in both eyes in children under 7 years old, who had at least three visits with available cycloplegic autorefraction records based on the electronic medical records (EMR) at the Zhongshan Ophthalmic Center between 2003 to 2023. Data on children’s demographic and clinical characteristics, including age, sex, best corrected visual acuity (BCVA) and presence of strabismus were also extracted from the EMR. Results A total of 930 children were included (median baseline age: 4.33 years, interquartile range [IQR], 3.42 to 5.25 years, 64.84% boys). The median baseline spherical equivalent (SE) was − 8.25D (IQR, -10.00D to -7.00D), and the median duration of follow-up was 2.85 years (IQR, 2.03 to 3.57 years). The mean myopia progression rate was − 0.33 (SD, 0.37) D/year, with 298 children (32.04%) demonstrated myopia progression of ≥ 0.50D/year. Older age (ß= -0.041, P < 0.001), boys (ß= -0.067, P = 0.012), and less myopic at baseline (ß= -0.013, P = 0.021) were associated with faster myopia progression. The percentage of children with BCVA > 0.5 (20/40) ranged from 11.27% among the 4-year-olds to 73.58% among the 8-year-olds. Conclusion In this real-world hospital-based dataset, two-thirds of children with eoHM do not experience rapid myopia progression. Boys, children with older age and less myopic SE at baseline are more likely to experience faster myopia progression.

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Profile of gut microbiome, plasma, and aqueous humor metabolome changes in high myopic cataract patients

Gu,

Ruan,

Yang

et al. 2024

Preprint

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Background: Inflammation contributed to myopia. Scarce evidence explored the relationship between systemic inflammation and high myopia. Thus, we aim to elucidate this issue via the “Gut-retina axis”. Methods: Patients with age-related cataracts (ARC) and high myopic cataracts (HMC) were included in the study. After comprehensive ophthalmic examinations, feces, plasma, and aqueous humor (AH) specimenswere collected from each patient.Detecting the V3-V4 region of 16S rDNA to obtain information on gut taxa and distinct gut taxa was obtained. LC-MS/MS systems were used to explore the metabolites of plasma and AH specimens. Using the “Dr. Tom” platform to find distinct metabolites. Then “corrplot” package and “pROC” package in R studio were conducted to find the relationship between gut taxa, metabolites, and axial lengths (AL). Results: Class Bacilli (P=0.008), Order Lactobacillales (P=0.013) and Burkholderiales (P=0.047), and Family Lactobacillaceae (P=0.003) were increased in the HMC group. Genus Roseburia in the HMC group was decreased (P=0.012). 79 and 197 distinct metabolites were found in the plasma and AH specimensrespectively. From KEGG analysis, the distinct plasma metabolites of HMC were enriched in “ABC transporters”, “Steroid hormone biosynthesis”, and “PPAR signaling pathway”, whilst “Protein digestion and absorption”, “Aminoacyl-tRNA biosynthesis”, and “D-Amino acid metabolism” pathways enriched in AH specimens. Finally, we identified the 4-Phenolsulfonic acid in plasma and 5'-N-Ethylcarboxamidoadenosine in AH may be potential biomarkers of high myopia. Conclusions: High myopic patients have distinct gut taxa and significantly different metabolites. Using multi-omics integrative analysis, new insights and biomarkers of high myopia will help us explore the pathogenesis of myopia. Trial registration: www.chictr.org.cn identifier is ChiCTR2300071397.

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Effect of Myopia Severity on the Health-Related Quality of Life in Children and Their Parents

Cited by 4 publications

References 23 publications

Les enjeux de la pandémie myopique

Les enjeux de la pandémie myopique

Longitudinal changes of refraction and visual acuity in children with early-onset high myopia

Profile of gut microbiome, plasma, and aqueous humor metabolome changes in high myopic cataract patients

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