Effect of N-acetylcysteine on liver and kidney function tests after surgical bypass in obstructive jaundice: A randomized controlled trial

Study the hepatoprotective effects and oxidant-antioxidant status of beta vulgaris roots ethanolic extract in hepatotoxic rats induced by acetaminophen

“…Moreover, the results indicated that the hepatotoxicity was not recovered after two weeks of stopping APAP dosing , while the treatment with Beta vulgaris roots ethanolic extract caused significant reduction in the levels of these serum enzymes which indicated the recovery of hepatotoxic effect nearly better than that recorded by NAC treatment at both periods (induced and 28 days) of treatments. Another study indicated that NAC could decrease AST, ALT and ALP levels and reduce hepatocellular injury due to its antioxidant effect (48), while the results of study by (49) also reported the reduced effects of NAC on the levels of serum AST, ALT and ALP.…”

Determination the levels of total bilirubin, total protein and liver histopathological changes in hepatotoxic rats and the role of Beta vulgaris roots ethanolic extract

“…The selected dose of NAC that has been used in this study was 70 mg/kg B.W according to (20). To prepare such dose for administration in rats, a sachet contained 600 mg of NAC was dissolved in 17.14 ml distilled water to prepare concentration of NAC 35 mg/ml that was given at a dose volume of 0.2 ml/100g B.W.…”

“…4. T2 group: Rats were daily administered (APAP) at dose (100 mg/kg) orally twice a day as (50 mg/kg) in the morning and (50 mg/kg) at the evening for 14 days followed by two weeks recovery and reference N-Acetylcysteine was given at dose (70 mg/kg) orally) once daily after 30 minutes post acetaminophen morning dose which continued for 28 days (20).…”