Effect of N-acetylcysteine on neutrophil functions during experimental acute pancreatitis

Atayoğlu, Kemal; Gurleyik, Gunay; Demirel, Gülderen Yanıkkaya; Özkara, Selvinaz

doi:10.5505/tjtes.2016.59844

Cited by 5 publications

(6 citation statements)

References 15 publications

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“…After duplicate articles were removed and articles screened for eligibility, full text of 24 articles were reviewed. Twelve of these articles were excluded for administration of multiple agents, texts not available in English and the administration of agents post induction of pancreatitis 23–34 . Twelve RCTs were included in the systematic review and meta‐analysis 35–46 …”

Section: Resultsmentioning

confidence: 99%

“…Twelve of these articles were excluded for administration of multiple agents, texts not available in English and the administration of agents post induction of pancreatitis. [23][24][25][26][27][28][29][30][31][32][33][34] Twelve RCTs were included in the systematic review and meta-analysis. [35][36][37][38][39][40][41][42][43][44][45][46] The characteristics of the included studies are shown in Table 1.…”

Section: Characteristics Of the Studiesmentioning

confidence: 99%

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Pharmacological prevention of post‐operative pancreatitis: systematic review and meta‐analysis of randomized controlled trials on animal studies

Cecire

Adams

Pham

et al. 2021

ANZ Journal of Surgery

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Background: Postoperative pancreatic fistula (POPF) remains a significant complication of pancreatic resection with recent evidence showing a strong association between postoperative pancreatitis and subsequent development of POPF. Incidence and severity of pancreatitis following endoscopic therapy has been effectively reduced with indomethacin prophylaxis, however further agents require evaluation. We present a systematic literature review and meta-analysis of the prophylactic treatment with corticosteroids or n-acetyl cysteine (NAC) of induced pancreatitis in rodent models. Methods: A systematic literature search was conducted using Pubmed, Medline, Embase and Cochrane library to identify eligible randomized control trials (RCT) involving animal models that examined NAC or corticosteroids. The primary outcome was the subsequent effect on serum amylase and IL-6 and the histopathological markers of severity such as pancreatic oedema and necrosis. Results: Four RCTs (n = 178) met inclusion criteria examining NAC and eight RCTs (n = 546) examining corticosteroid agents (dexamethasone, hydrocortisone, methylprednisolone). Prophylactic administration of all corticosteroid agents showed a net effect in favour of reducing markers of severity of pancreatitis. NAC showed a significant reduction in severity of amylase and necrosis. Conclusion:The RCTs examined suggest that prophylactic administration of corticosteroid agents and NAC can reduce the severity of pancreatitis as indicated by histopathologic markers, serum amylase and IL-6 levels.

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Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of the Studiesmentioning

confidence: 99%

Pharmacological prevention of post‐operative pancreatitis: systematic review and meta‐analysis of randomized controlled trials on animal studies

Cecire

Adams

Pham

et al. 2021

ANZ Journal of Surgery

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“…A previous study suggested that N-acetylcysteine treatment ameliorated pulmonary and renal tissue damages in all microscopic parameters [ 15 ]. Other studies have shown that anti-HMGB1 treatment protected against renal injury in experimental acute pancreatitis [ 16 – 18 ].…”

Section: Discussionmentioning

confidence: 99%

Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein

Çakır

Fındık

2018

Gastroenterology Research and Practice

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Aim We determined the effects of diclofenac sodium, octreotide, and their combination on extrapancreatic organ injuries in caerulein-induced acute pancreatitis in mice. Methods A total of 58 BALB-C male mice (25 g) were divided into seven groups and used to create a caerulein-induced acute pancreatitis model. Diclofenac sodium, octreotide, and their combination were given for treatment of caerulin-induced acute pancreatitis in mice. At the end of the experiment, the lung, liver, kidney, and stomach were removed for histopathologic assessment. Results Histopathologic investigation revealed a statistically significant difference between the groups in mean congestion, edema, tubular injury, perirenal fat tissue inflammation, and tubular stasis scores in kidney tissue (P < 0.001, P < 0.001, P < 0.001, P < 0.001, and P = 0.048, respectively); mean congestion, edema, neutrophil inflammation, mononuclear inflammation, and emphysematous change scores in the lung (P < 0.001, P < 0.001, P < 0.001, P = 0.030, and P < 0.001, respectively); mean congestion, edema, and neutrophil inflammation scores in the stomach (P = 0.008, P = 0.014, and P < 0.001, respectively); and mean congestion and hydropic degeneration scores in the liver (P = 0.029 and P = 0.002, respectively). Conclusion Diclofenac sodium alone ameliorates lung edema due to caerulin-induced acute pancreatitis.

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“…While various antioxidant enzymes depletion, including superoxide dismutase (SOD), catalase, and GSH, often occurred in pancreatitis, it is acknowledged that the replenishment of antioxidant agents, e.g. NAC, have been recognized as a feasible idea for acute pancreatitis therapy (Atayoglu, 2016 ). However, a recent double-blind placebo (PL)-controlled randomized pilot study indicated the simple supplementation with antioxidant to patients obtained no additional therapeutic benefits on endocrine and exocrine function, fibrosis progression, and the severity of oxidative stress and inflammation (Singh et al., 2019 ).…”

Section: Formulation Approaches For Acute Pancreatitismentioning

confidence: 99%

Drug discovery and formulation development for acute pancreatitis

et al. 2020

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Acute pancreatitis is a sudden inflammation and only last for a short time, but might lead to a life-threatening emergency. Traditional drug therapy is an essential supportive method for acute pancreatitis treatment, yet, failed to achieve satisfactory therapeutic outcomes. To date, it is still challenging to develop therapeutic medicine to redress the intricate microenvironment promptly in the inflamed pancreas, and more importantly, avoid multi-organ failure. The understanding of the acute pancreatitis, including the causes, mechanism, and severity judgment, could help the scientists bring up more effective intervention and treatment strategies. New formulation approaches have been investigated to precisely deliver therapeutics to inflammatory lesions in the pancreas, and some even could directly attenuate the pancreatic damages. In this review, we will briefly introduce the involved pathogenesis and underlying mechanisms of acute pancreatitis, as well as the traditional Chinese medicine and the new drug option. Most of all, we will summarize the drug delivery strategies to reduce inflammation and potentially prevent the further development of pancreatitis, with an emphasis on the bifunctional nanoparticles that act as both drug delivery carriers and therapeutics.

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Effect of N-acetylcysteine on neutrophil functions during experimental acute pancreatitis

Cited by 5 publications

References 15 publications

Pharmacological prevention of post‐operative pancreatitis: systematic review and meta‐analysis of randomized controlled trials on animal studies

Pharmacological prevention of post‐operative pancreatitis: systematic review and meta‐analysis of randomized controlled trials on animal studies

Diclofenac Sodium Treatment Ameliorates Extrapancreatic Organ Injuries in a Murine Model of Acute Pancreatitis Induced by Caerulein

Drug discovery and formulation development for acute pancreatitis

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