Effect of N-acetylcysteine treatment on oxidative stress and inflammation after severe burn

Glial and neuroinflammatory targets for treating substance use disorders

“…Restoration of opioid-induced GLT-1 deficits with chronic administration of the cysteine pro-drug, N-acetylcysteine, was also effective in reducing heroin seeking (Murray et al, 2012; Reissner et al, 2015; Zhou and Kalivas, 2008). Interesting, both ceftriaxone and N-acetylcysteine display anti-inflammatory properties making it difficult to disentangle their ability to suppress immune activation from their effects on restoring glutamate homeostasis (Csontos et al, 2012; Karalija et al, 2014; Kaur and Prakash, 2017; Lujia et al, 2014; Mahmoud and Ammar, 2011; Purwanto and Prasetyo, 2012; Wei et al, 2012). Regardless, it seems that opioid-induced immune activation and disrupted glutamate homeostasis may be interrelated phenomena that alter neuronal functioning ultimately influencing the behavioral effects of acute and chronic opioid administration.…”

“…An interesting feature of both ceftriaxone and N-acetylcysteine is that their administration produces relatively lasting reductions in drug seeking when tested in animal models (Madayag et al, 2007; Murray et al, 2012; Reichel et al, 2011). Both ceftriaxone and N-acetylcysteine possess anti-inflammatory effects in addition to reversing psychostimulant-induced changes in GLT1 and restoring glutamate homeostasis (Csontos et al, 2012; Karalija et al, 2014; Kaur and Prakash, 2017; Lujia et al, 2014; Mahmoud and Ammar, 2011; Purwanto and Prasetyo, 2012; Wei et al, 2012). These findings prompt the interesting notion that immune activation and glutamate homeostasis are not mutually exclusive and may be interrelated phenomena that contribute to the neuropathology of drug abuse.…”

Treatment with N-acetylcysteine does not alter blood glucose levels and the oxidative stress status in diabetic rats

“…[7,10] There is a correlation between ROS production and inflammation, in which superoxide anion production is increased in vivo during the inflammatory process. [1,45] It has been seen that NAC has anti-inflammatory properties by regulating ROS production. [45] In this regard, Guo et al, [10] have demonstrated that NAC supplementation decreases the inflammatory factors, preventing the increase of anion superoxide production and improving the total antioxidant capacity in diabetic rats.…”

“…[1,45] It has been seen that NAC has anti-inflammatory properties by regulating ROS production. [45] In this regard, Guo et al, [10] have demonstrated that NAC supplementation decreases the inflammatory factors, preventing the increase of anion superoxide production and improving the total antioxidant capacity in diabetic rats. However, in our study, there has been no increment in the antioxidant system in the diabetic rats treated with NAC.…”

Individualizing Optimal Fluid Resuscitation in Patients with Major Burns: Emerging Role for Hydrocortisone, Proteinuria and Brain Natriuretic Peptide

“…First, prompt wound excision and fluid resuscitation has been shown to decrease the extent of the inflammatory response [24]. In man, N-acetylcysteine and the combination of recombinant human growth hormone and propranolol [25,26] and in animals pentoxifylline and ulinastatin also attenuated the inflammatory response [27,28]. High doses of ascorbic acid given early significantly reduced resuscitation fluid volume requirements [29].…”