Effect of nacre extract from pearl oyster shells against behavioral and psychological symptoms of dementia in senescence-accelerated mouse P8 (SAMP8)

Omachi, Tomoki; Hasegawa, Yasushi

doi:10.1016/j.jff.2024.106208

Cited by 1 publication

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“…Our previous study demonstrated that NE derived from the pearl oyster shells improved memory impairment in scopolamine-induced memory impairment model mice and amyloid β-induced memory impairment model mice [ 30 , 31 , 32 ]. NE has also been shown to be effective against lipopolysaccharide-induced depression and anxiety [ 33 , 34 ]. In addition, intraperitoneal administration of NE prevents d-galactose-induced brain and skin aging [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Oral Administration of Nacre Extract from Pearl Oyster Shells Has Anti-Aging Effects on Skin and Muscle, and Extends the Lifespan in SAMP8 Mice

Yamamoto,

Shimomura,

Hasegawa

2024

Pharmaceuticals

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Pearl oysters have been extensively utilized in pearl production; however, most pearl oyster shells are discarded as industrial waste. In a previous study, we demonstrated that the intraperitoneal administration of pearl oyster shell-derived nacre extract (NE) prevented d-galactose-induced brain and skin aging. In this study, we examined the anti-aging effects of orally administered NE in senescence-accelerated mice (SAMP8). Feeding SAMP8 mice NE prevented the development of aging-related characteristics, such as coarse and dull hair, which are commonly observed in aged mice. Additionally, the NE mitigated muscle aging in SAMP8 mice, such as a decline in grip strength. Histological analysis of skeletal muscle revealed that the NE suppressed the expression of aging markers, cyclin-dependent kinase inhibitor 2A (p16) and cyclin-dependent kinase inhibitor 1 (p21), and increased the expression of sirtuin1 and peroxisome proliferator-activated receptor gamma coactivator 1 (PGC1)- α, which are involved in muscle synthesis. These findings suggest that the oral administration of NE suppresses skeletal muscle aging. Moreover, NE administration suppressed skin aging, including a decline in water content. Interestingly, oral administration of NE significantly extended the lifespan of SAMP8 mice, suggesting that its effectiveness as an anti-aging agent of various tissues including skeletal muscle, skin, and adipose tissue.

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