“…Identifying and quantifying the hazards presented by nanoparticles, if any, and addressing them in order to reduce eventually determined risks are, and will be, a key research topic in the future of food packaging research. A good number of studies have been targeted at the identification of nanomaterial hazards in food packaging, however, it is acknowledged that there is still considerable uncertainty about the potential harmful effects associated with nanoscale particles (Cushen, Kerry, Morris, Cruz-Romero, & Cummins, 2013, 2014a, 2014bHannon et al, 2015;Kuorwel, Cran, Orbell, Buddhadasa, & Bigger, 2015;Llorens, Lloret, Picouet, Trbojevich, & Fernandez, 2012;Panea, Ripoll, González, Fernández-Cuello, & Albertí, 2014 (Donaldson, Stone, Tran, Kreyling, & Borm, 2004;Goodman, McCusker, Yilmaz, & Rotello, 2004;Sun, Fu, Lin, & Huang, 2002). Nanoparticles of a few nanometers in size can also cross the cell membrane and enter the cell cytoplasm.…”