Effect of nanodiamond surface chemistry on adsorption and release of tiopronin

Bilayer Adsorption of Lysozyme on Nanodiamonds in Aqueous Suspensions

“…Nanodiamonds are good adsorbents of various substances. − The corresponding functionalization of the ND surface provides it with high selective adsorption activity for heavy metal ions, nitrates, , proteins and DNA molecules, − drugs, , viruses, etc. It was shown by many authors that metal ions, nitrates, proteins, e.g., cytochrome c, or many drugs such as doxorubicin are adsorbed on the surface of nanodiamonds through physical adsorption.…”

Pickering emulsions stabilized by carboxylated nanodiamonds over a broad pH range

“…Then, electrostatic repulsive forces between adjacent ND particles become stronger, thereby reducing the possibility of flocculation. [40][50] Interestingly, at pH 12 NaOH, the presence of Na + ions reduces the electrostatic repulsion between particles, which considerably reduces the absolute value of the zeta potential. [51] In contrast, at pH 2, the zeta potential was close to 0, and large aggregates of about 2 µm in size were formed.…”

“…(For brevity, we will not hereafter always use the adjective "carboxylated", as our experiments only used this type of ND.) Carboxylic functionalization provides greater ND colloidal stability when dispersed in polar solvents [38][39][40] as well as enhanced ND biocompatibility, which are of great importance for their applications in biomedicine [41]. We investigated the effect of pH and dissolved ions on the mechanical and storage stability of the emulsions.…”

Solubility Measurement of Tiopronin in Four Mixed Solvents at 273.15–318.15 K and Correlation Using Thermodynamic Models

“…NO. 1953-02-2, and chemical name, N -(2-mercaptopropionyl) glycine, Figure ] is a pharmaceutically important compound with weak acidity. , Because tiopronin is an important antioxidant and the most abundant nonprotein thiol in the human body, the mechanism of its action in medical effect is the direct scavenging of free radicals and maintenance of healthy levels of glutathione. , It could be used to protect against ischemic/reperfusion-mediated injury and against radiation-induced damages, even at low doses. , In addition, tiopronin is also used in the treatment of cystinuria and rheumatoid arthritis since the 1980s in Western countries. , In China, it was used to protect against numerous liver diseases, including fatty liver disease, drug-induced liver injury, and viral hepatitis as well as an antidote to heavy metal poisoning. − …”

“…1953-02-2, and chemical name, N-(2-mercaptopropionyl) glycine, Figure 1] is a pharmaceutically important compound with weak acidity. 1,2 Because tiopronin is an important antioxidant and the most abundant nonprotein thiol in the human body, the mechanism of its action in medical effect is the direct scavenging of free radicals and maintenance of healthy levels of glutathione. 3,4 It could be used to protect against ischemic/reperfusion-mediated injury and against radiation-induced damages, even at low doses.…”