“…BC has also been used widely in biomedical applications such as wound-dressing [ 44 , 45 , 46 , 47 ] (applied on the wounded torso, hand, and face) and cell culture [ 48 , 49 , 50 , 51 ] because of its excellent flexibility, high mechanical strength at wet state, water holding capacity, very low risk for irritation due to its ultra-high purity, hygroscopicity, liquid/gasses permeability, and ease of wound inspection due to its transparency. Biopolymer such as polylactic acid (PLA), starch, polyhydroxyalkanoate (PHA) [ 52 , 53 , 54 , 55 , 56 ], and synthetic polymer such as polyvinyl alcohol (PVA) and unsaturated polyester (UP) [ 57 , 58 ] are potential polymers to be reinforced with BC. The outstanding properties of BC such as biodegradability, good controllability during BC production, and possessing net-like morphology that is almost similar to human collagen as a biomimetic feature makes it favoured in the medical field and has been widely utilized in controlled drug delivery [ 59 ], medical pads [ 41 ], artificial skin [ 7 , 60 ], cartilage [ 61 ] and bone [ 62 , 63 ], bone tissue engineering scaffolds [ 64 , 65 , 66 ], hormones [ 72 ], and nerve guides for spinal cord injury treatment [ 73 ].…”