Poly(Lactic-co-glycolic) acid (PLGA) is a biopolymer with numerous opportunities for medical science and environmental application. Tailoring the surface behavior of hydrophobic PLGA is important for many of their applications. Carbon nanotubes are graphene derivatives that have superior thermal, mechanical, electrical, and optical properties. Much research has been devoted to enhancing the properties of polymers using nanomaterials. In this research, composites of PLGA and multiwall carbon nanotube (MWNT) were prepared by using the solution cast technique with different MWNT contents. These composites are processed using microwave radiation to modify the surface behavior. The effects of processing are investigated using different techniques such as Contact angle measurement, Fourier transform infrared spectroscopy, and bacterial interactions. It is observed that microwave radiation modifies the surface behavior without introducing any additional surface functionalities. This is clearly observed from the bacterial investigation where microwave radiation increased bacterial growth in PLGA composites with 1% MWNT compared to pure polymer and 5% PLGA/MWNT composites. This demonstrates the use of microwave radiation as a promising tool for material modification that can be used to tailor surface characteristics for biomedical applications such as bioscaffolds.