Nanofluids play important roles in the heat transfer and flow characteristics in ribbed square channels. Systematic experiments are conducted to measure heat transfer enhancement and TiO ଶ െ H ଶ O based nanofluid flow characteristics on a protruded with combined V-type ribbed square channel. Reynolds number studied in the channel range from 4000-18000. Investigational parameters of square channel contain, volume fraction range of 1.0-4.0%, particle diameter range of 30nm-45nm, relative protruded rib height range of 0.10-0.25, ratio of protruded height to print diameter range of 0.8-2.0, relative protruded rib pitch ratio range of 2.0-3.5 and angle of attack of 30 0 -75 0 respectively. Results indicates that the thermal performance of the protruded combined V-type ribbed square channel falls with increasing Reynolds number. The highest value of thermal hydraulic performance parameter is found to be 3.21for the range of parameters investigated. Correlations predicting Nusselt number and friction factor as a function of volume fraction, particle diameter range, relative protruded rib height, ratio of protruded height to print diameter, relative protruded rib pitch ratio, angle of attack and flow parameter. The correlations for Nusselt number and friction factor have also been developed on the basis of experimental data with considerable good accuracy.