In esthetic restorative dentistry, resin composites are generally encountered. Because of their excellent biocompatibility, lack of taste, odour, tissue discomfort, and toxicity, insolubility in body fluids, ease of use, good clinical/ aesthetic properties, stable colours, optical characteristics, efficient pigmentation, low cost, and repairability, they are becoming more common. Currently used composite resins have some flaws, particularly inconsistent mechanical properties. For a long time, particles of various sizes have been used as fillers to enhance these properties. In prosthodontics, poly(methyl methacrylate) (PMMA) is commonly used as a dental base material. It does, nevertheless, have several weaknesses, including low strength and weak thermal properties. The effects of different sizes of alumina (Al2O3) particles on the poly(methyl ethacrylate) (PMMA) denture base were determined in this experiment. PMMA powder was blended with Al2O3 added to methyl methacrylate (MMA).For PMMA polymeric materials strengthened with Al2O3 (40 nm, 140 nm and 0.3-0.8 μm) in various concentrations, the mechanical properties were studied.Also, the synergetic influence of the three nanoparticle sizes in the resin matrix was studied.Furthermore, thermogravimetric (TGA) analysis and water absorption and solubility characteristics of the composites prepared were also examined. Among the most significant properties to be obtained for good denture materials is high mechanic properties, water absorption and solubility, since they have different attributes in the aqueous condition of the oral cavity. Results showed clear properties optimization, especially for the size-hybrid alumina composites.