Effect of naproxen on the model lipid membrane formed on the water-chitosan subphase

Przykaza, Kacper; Jurak, Małgorzata; Wiącek, Agnieszka Ewa

doi:10.1016/j.bbamem.2022.184099

Cited by 3 publications

(1 citation statement)

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“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are therapeutic drugs that inhibit the cyclooxygenase pathway; hence, they are used against fever, inflammation, and pain [ 14 , 15 , 16 ]. Common representatives are naproxen, ibuprofen, and diclofenac [ 17 ], which all interact with phospholipid membranes [ 15 , 16 , 18 , 19 , 20 , 21 ]. In this study, naproxen ( Figure 1 b) is used as representative of this substance class and in comparison to the prior investigated ibuprofen [ 10 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin

et al. 2023

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In this study, the interplay among the phospholipid 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) as a model membrane, the nonsteroidal anti-inflammatory drug naproxen, and the saponin β-aescin are investigated. The naproxen amount was fixed to 10 mol %, and the saponin amount varies from 0.0 to 1.0 mol%. Both substances are common ingredients in pharmaceutics; therefore, it is important to obtain deeper knowledge of their impact on lipid membranes. The size and properties of the DMPC model membrane upon naproxen and aescin addition were characterized with differential scanning calorimetry (DSC), small- and wide-angle X-ray scattering (SAXS, WAXS), and photon correlation spectroscopy (PCS) in a temperature-dependent study. The interaction of all substances was dependent on the lipid phase state, which itself depends on the lipid’s main phase transition temperature Tm. The incorporation of naproxen and aescin distorted the lipid membrane structure and lowers Tm. Below Tm, the DMPC–naproxen–aescin mixtures showed a vesicle structure, and the insertion of naproxen and aescin influenced neither the lipid chain–chain correlation distance nor the membrane thickness. Above Tm, the insertion of both molecules instead induced the formation of correlated bilayers and a decrease in the chain–chain correlation distance. The presented data clearly confirm the interaction of naproxen and aescin with DMPC model membranes. Moreover, the incorporation of both additives into the model membranes is evidenced.

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Section: Introductionmentioning

confidence: 99%

Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin

et al. 2023

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Naproxen-loaded mesoporous silica nanoparticles: How can the process of incorporation affect drug placement, drug release and the in vitro naproxen irritant potential?

Funk,

Tavaniello,

Dos Santos

et al. 2025

Microporous and Mesoporous Materials

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Enhanced Stability and In Vitro Biocompatibility of Chitosan-Coated Lipid Vesicles for Indomethacin Delivery

Abu Koush,

Popa,

Pricop

et al. 2024

Pharmaceutics

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Background: Lipid vesicles, especially those utilizing biocompatible materials like chitosan (CHIT), hold significant promise for enhancing the stability and release characteristics of drugs such as indomethacin (IND), effectively overcoming the drawbacks associated with conventional drug formulations. Objectives: This study seeks to develop and characterize novel lipid vesicles composed of phosphatidylcholine and CHIT that encapsulate indomethacin (IND-ves), as well as to evaluate their in vitro hemocompatibility. Methods: The systems encapsulating IND were prepared using a molecular droplet self-assembly technique, involving the dissolution of lipids, cholesterol, and indomethacin in ethanol, followed by sonication and the gradual incorporation of a CHIT solution to form stable vesicular structures. The vesicles were characterized in terms of size, morphology, Zeta potential, and encapsulation efficiency and the profile release of drug was assessd. In vitro hemocompatibility was evaluated by measuring erythrocyte lysis and quantifying hemolysis rates. Results: The IND-ves exhibited an entrapment efficiency of 85%, with vesicles averaging 317.6 nm in size, and a Zeta potential of 24 mV, indicating good stability in suspension. In vitro release kinetics demonstrated an extended release profile of IND from the vesicles over 8 h, contrasting with the immediate release observed from plain drug solutions. The hemocompatibility assessment revealed that IND-ves exhibited minimal hemolysis, comparable to control groups, indicating good compatibility with erythrocytes. Conclusions: IND-ves provide a promising approach for modified indomethacin delivery, enhancing stability and hemocompatibility. These findings suggest their potential for effective NSAID delivery, with further in vivo studies required to explore clinical applications.

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Effect of naproxen on the model lipid membrane formed on the water-chitosan subphase

Cited by 3 publications

References 62 publications

Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin

Interactions between DMPC Model Membranes, the Drug Naproxen, and the Saponin β-Aescin

Naproxen-loaded mesoporous silica nanoparticles: How can the process of incorporation affect drug placement, drug release and the in vitro naproxen irritant potential?

Enhanced Stability and In Vitro Biocompatibility of Chitosan-Coated Lipid Vesicles for Indomethacin Delivery

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