Effect of narasin supplementation on performance of lambs fed high-forage diets

Polizel, Daniel Montanher; Sardinha, Lairana A; Limede, Arnaldo Cintra; Miszura, Alexandre Arantes; Barroso, Juliana Machado; Sturion, Thamires U; Soares, Letícia Carolina Bortolanza; Marques, R. S.; Biava, Janaína Socolovski; Ferraz, Marcos Vinícius de Castro; Ferreira, Evandro Maia; Pires, Alexandre Vaz

doi:10.1016/j.smallrumres.2021.106549

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…Accordingly, others have also shown that the inclusion of NAR ( Silva et al, 2015 ; Pasqualino et al, 2020 ; Polizel et al, 2020 ), LAS, monensin, or flavomycin ( DelCurto et al, 1998 ; Limede et al, 2021 ) did not influence DMI in animals fed forage-based diets. Conversely, and supporting our results, Polizel et al (2021) reported that supplementing NAR to lambs consuming low- (7% CP) or medium- (11.7% CP) quality forage increased DMI, regardless of forage quality. The interaction between forage quality and additive doses can drive the DMI in livestock animals in forage-based systems ( Bretschneider et al, 2008 ; Ellis et al, 2012 ).…”

Section: Discussionsupporting

confidence: 90%

Effects of lasalocid, narasin, or virginiamycin supplementation on rumen parameters and performance of beef cattle fed forage-based diet

Miszura

Marques

Polizel

et al. 2023

Journal of Animal Science

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Two experiments were designed to evaluate the impacts of supplementing lasalocid, narasin, or virginiamycin on rumen fermentation parameters, apparent nutrient digestibility, and blood parameters (Exp. 1), as well as feed intake and performance (Exp. 2) of Nellore cattle consuming a forage-based diet. In Exp. 1, thirty-two rumen-fistulated Nellore steers (initial shrunk BW = 355 ± 4.4 kg) were assigned to a randomized complete block design. Within block, animals were randomly assigned to 1 of 4 treatments: 1) forage-based diet without feed additives (CON), 2) CON diet plus 13 mg/kg of DM of narasin (NAR), 3) CON diet plus 20 mg/kg of DM of sodium lasalocid (LAS), or 4) CON diet plus 20 mg/kg of DM of virginiamycin (VRM). No treatment effects were detected (P ≥ 0.32) for intake and apparent digestibility of nutrients. Steers fed NAR had the lowest (P ≤ 0.01) molar proportion of acetate on d 28, 56, and 112 vs. CON, LAS, and VRM steers, whereas acetate did not differ (P ≥ 0.25) between LAS, VRM, and CON steers from d 28 to 84. On d 112, steers fed LAS had a lower (P < 0.02) molar proportion of acetate vs. VRM and CON, whereas it did not differ between CON and VRM (P > 0.33). Steers receiving NAR had a greater (P ≤ 0.04) ruminal propionate vs. CON, LAS, and VRM, whereas LAS steers had greater (P < 0.04) propionate vs. CON and VRM steers on d 28 and 112, and it did not differ (P > 0.22) between CON and VRM. In Exp. 2, one hundred and sixty Nellore bulls were blocked by initial shrunk BW (212 ± 3.1 kg) in a 140-d feedlot trial. Diets contained the same treatments used in Exp.1. Bulls fed NAR had greater (P < 0.02) ADG vs. CON and VRM, and similar (P = 0.17) ADG between NAR and LAS, whereas ADG did not differ (P > 0.28) between LAS, VRM, and CON bulls. A treatment effect was detected (P = 0.03) for DMI, being greater in NAR vs. CON, LAS, and VRM bulls, and similar (P > 0.48) between CON, LAS, and VRM bulls. A tendency was detected (P = 0.09) for feed efficiency, which was greater (P < 0.02) in NAR bulls vs. CON and VRM, and similar (P = 0.36) between NAR and LAS bulls. From d 112 to 140, bulls receiving NAR were heavier (P < 0.03) vs. CON, LAS, and VRM bulls, but no differences were observed (P > 0.51) between CON, LAS, and VRM bulls. Collectively, ruminal fermentation profile and intake were impacted by narasin supplementation, which partially contributed to the enhanced performance of Nellore bulls receiving a forage-based diet.

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Section: Discussionsupporting

confidence: 90%

Effects of lasalocid, narasin, or virginiamycin supplementation on rumen parameters and performance of beef cattle fed forage-based diet

Miszura

Marques

Polizel

et al. 2023

Journal of Animal Science

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“…Community researchers are interested in employing the ionophore narasin in a forage-based diet because of the possible advantage in performance and ruminal fermentation characteristics, with no direct impact on forage intake ( Limede et al, 2021 ; Miszura et al, 2023 ), as normally observed in diets utilizing monensin ( Duffield et al, 2012 ; Polizel et al, 2021b ). Polizel et al (2021c) observed that including 13 and 20 mg/kg of DM of narasin linearly increased the intake of lambs fed a high-quality haylage (CP = 148 g/kg of DM; NDF = 586 g/kg of DM). Additionally, the authors evaluated the interaction between forage quality and narasin and reported that narasin increased nutrient intake regardless of forage quality ( Polizel et al, 2021c ).…”

Section: Discussionmentioning

confidence: 96%

“… Polizel et al (2021c) observed that including 13 and 20 mg/kg of DM of narasin linearly increased the intake of lambs fed a high-quality haylage (CP = 148 g/kg of DM; NDF = 586 g/kg of DM). Additionally, the authors evaluated the interaction between forage quality and narasin and reported that narasin increased nutrient intake regardless of forage quality ( Polizel et al, 2021c ). In the present study, however, including 13 mg/kg of DM of narasin did not improve nutrient intake and digestibility of steers fed different haylage quality.…”

Section: Discussionmentioning

confidence: 96%

Effect of forage quality and narasin inclusion on ruminal fermentation, nutrient intake, and total tract digestibility of Nellore steers

de Paula,

Marques,

Pires

et al. 2024

Translational Animal Science

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The study aimed to evaluate the effects of forage quality and narasin inclusion on intake, digestibility, and ruminal fermentation of Nellore steers. Twenty-eight rumen-cannulated Nellore steers [initial body weight (BW) = 350 ± 32.4 kg] were allocated to individual pens in a randomized complete block design, with 7 blocks, defined according to the fasting BW at the beginning of the experiment. The steers were randomly assigned within blocks to 1 of 4 experimental diets in 2 × 2 factorial arrangements, being the first-factor forage quality (MEDIUM = 81 g of CP/ kg of DM, and HIGH = 153 g of CP/ kg of DM), and the second factor was the inclusion (N13 = diet plus 13 mg/kg of DM of narasin) or not (N0) of narasin (Zimprova; Elanco Animal Health, São Paulo, Brazil). The experiment consisted of a 28 d period with 22 d for adaptation and the last 6 days for data collection. No haylage quality × narasin interaction (P ≥ 0.68) was observed on dry matter and nutrient intake. Haylage quality affected (P ≤ 0.01) DM intake, with greater values observed for steers fed HIGH compared with MEDIUM haylage. There was an increase (P < 0.001) in OM, NDF, hemicellulose, and CP intake for steers consuming HIGH vs. MEDIUM haylage. Including N13 did not affect (P > 0.39) DM and nutrient intake of steers. No haylage quality × narasin interactions were detected (P ≥ 0.60) for total tract nutrient digestibility. However, steers fed with HIGH haylage showed an increase (P > 0.001) in DM and digestibility of all nutrients compared with MEDIUM. Steers fed a MEDIUM haylage had a greater (P < 0.01) proportion of acetate compared with steers fed HIGH during all evaluated hours. Steers fed HIGH haylage had a greater (P < 0.01) proportion of propionate at 0 h compared with steers consuming MEDIUM, whereas at 12 h, steers consuming MEDIUM hay had a greater (P < 0.01) proportion of propionate vs. HIGH haylage. A haylage quality × narasin and haylage quality × time of collection interactions were detected (P ≤ 0.03) for rumen ammonia concentration, which was reduced (P < 0.03) in N13 vs. N0 steers consuming HIGH haylage. Collectively, high-quality haylage allows increased consumption and digestibility, with more energy-efficient ruminal fermentation. In addition, narasin might be an important nutritional tool in forage-based diets to enhance ruminal fermentation parameters of Bos Indicus Nellore steers.

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“…These findings support many of the findings that LAS supplementation led to an increase in BWG, ADG, DMI, and FCR in growing goats ( 12 , 37 ). Additionally, a study conducted by Polizel et al ( 38 ) indicated that LAS supplementation at 13 ppm led to increasing ADG in sheep and growing lambs. Therefore, our results suggest that LAS supplementation can improve feed efficiency ( 35 ) and increase BWG and ADG, which is consistent with previous studies ( 31 , 39 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of increasing levels of lasalocid supplementation on growth performance, serum biochemistry, ruminal fermentation profile, in vitro nutrient digestibility, and gas production of growing goats

Basmaeil,

Suliman,

Al Garadi

et al. 2023

Front. Vet. Sci.

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IntroductionLasalocid is a feed additive widely used in ruminant nutrition and plays a crucial role in improving livestock productivity, digestibility, immunity, and overall wellbeing. The current study was conducted to investigate the effect of different levels of lasalocid (LAS) supplementation on growth performance, serum biochemistry, ruminal fermentation profile, in vitro nutrient digestibility, and gas production of growing goats.MethodsA total of 60 growing Aardi male goats with an average body weight of ~17.12 kg (3-month-old) were used for an 84-day trial. Animals were randomly divided into four treatment groups with 5 replicates of 3 goats each. All four groups were provided with a basal diet supplemented with lasalocid (LAS) at 0 (without supplementation; LAS0), 10 (LAS10), 20 (LAS20), or 30 (LAS30) ppm LAS/kg dry matter (DM). Feed intake was measured weekly, and goats were weighed every 2 weeks for an evaluation of the performance parameters. Blood samples were collected for the measurement of biochemical variables. In vitro nutrient digestibility and gas production were evaluated.Results and discussionThe supplementation of LAS at level 30 ppm/kg DM increased (P < 0.05) the body weight gain and average daily gain without linear or quadratic effect. The serum concentrations of high-density lipoprotein were significantly (P < 0.05) higher in the LAS20 group than in other groups with linear and quadratic effects, while low-density lipoprotein concentration was significantly lower in the LAS20 group than in LAS0 and LAS30 with a linear effect. Different levels of lasalocid supplementation had no effect on the ruminal fermentation profile, in vitro gas production, and nutrient digestibility. In conclusion, the addition of LAS (20–30 ppm/kg DM) to the goat's diet can improve the growth performance and lipoprotein profile.

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Effect of narasin supplementation on performance of lambs fed high-forage diets

Cited by 3 publications

References 12 publications

Effects of lasalocid, narasin, or virginiamycin supplementation on rumen parameters and performance of beef cattle fed forage-based diet

Effects of lasalocid, narasin, or virginiamycin supplementation on rumen parameters and performance of beef cattle fed forage-based diet

Effect of forage quality and narasin inclusion on ruminal fermentation, nutrient intake, and total tract digestibility of Nellore steers

Effects of increasing levels of lasalocid supplementation on growth performance, serum biochemistry, ruminal fermentation profile, in vitro nutrient digestibility, and gas production of growing goats

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