Effect of Narrow Band –UVB Phototherapy on Circulating T-Regulatory cells and Serum IL-17 Level in Egyptian Patients with Non-Segmental Vitiligo

Ghanem, Bothaina Mahrous; Mitwally, Shereen Salah; State, Ahmed Fathy; Elshawaf, Rasha Abdelgawad Mohammed

doi:10.21608/ejhm.2021.194064

Cited by 2 publications

(2 citation statements)

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“…Nevertheless, our meta-analysis suggested a trend of increased Treg cells' frequency after treatment as there was 1.16 SMD increase in Tregs' frequency after treatment (Figure 5(a)). Moreover, our meta-analysis suggested improved Tregs' frequency, FOXP3, and IL-10 expression posttreatment in human and mice model studies, which is in concordance to the previous studies [47][48][49][50][51][52][53].…”

Section: Discussionsupporting

confidence: 91%

“…Additionally, polymeric nanoparticles containing rapamycin and autoantigens induce antigen-specific immune tolerance, thereby inhibiting vitiligo in mouse models of vitiligo [ 53 ]. Furthermore, in human studies, tacrolimus, miR-155, and HO-1 increase the IL-10 expression in vitiligo lesions, whereas narrow band-UVB phototherapy, miR-21-5p, and miR-155 enhance the Tregs' frequency and FOXP3 levels, thereby suppressing the melanocyte destruction caused by unregulated Th1 pathways [ 19 , 21 , 48 , 49 , 52 ]. Therefore, such Treg-based therapeutics can control depigmentation and support immune tolerance in vitiligo.…”

Section: Discussionmentioning

confidence: 99%

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Meta-Analysis of Alterations in Regulatory T Cells’ Frequency and Suppressive Capacity in Patients with Vitiligo

Giri

Mistry

Dwivedi

2022

Journal of Immunology Research

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Vitiligo is a noncontagious autoimmune skin depigmenting disease. Regulatory T cells (Tregs) play a key role in maintaining peripheral tolerance; however, Tregs' number, suppressive function, and associated suppressive molecules (FOXP3, IL-10, and TGF- β ) are found to be reduced in vitiligo patients. Although, the role of Tregs in vitiligo pathogenesis is well established, there are several contrary findings which suggest a controversial role of Tregs in vitiligo. Therefore, to clarify the role of Tregs in vitiligo pathogenesis, we aimed to study Tregs' frequency, suppressive capacity, and associated suppressive molecules (FOXP3, IL-10, and TGF- β ) in vitiligo patients through meta-analysis approach. A total of 30 studies involving 1223 vitiligo patients and 1109 controls were included in the study. Pooled results from our meta-analysis suggested significantly reduced Treg cells' frequency in vitiligo patients ( p = 0.002). Interestingly, Tregs' suppressive capacity was also significantly reduced in vitiligo patients ( p = 0.0002); specifically, Treg-mediated suppression of CD8 + T cells was impaired in vitiligo patients ( p < 0.00001). Moreover, FOXP3, a key Tregs' transcription factor, was significantly reduced in blood and skin of vitiligo patients ( p < 0.00001). Intriguingly, the FOXP3 expression was significantly reduced in the lesional skin as compared to perilesional and nonlesional skin ( p = 0.007 and p = 0.04). Furthermore, the expression of key Treg-associated suppressive cytokines IL-10 and TGF- β were significantly reduced in vitiligo patients ( p = 0.0005 and p = 0.01). The disease activity-based analysis suggested for reduced Tregs' frequency and FOXP3 expression in active vitiligo patients ( p = 0.05 and p = 0.01). We also studied the effect of microRNA-based treatment, narrow band–UVB phototherapy, and Treg-associated treatments on Tregs' frequency, FOXP3, and IL-10 expression. Interestingly, we found increased Tregs' frequency, FOXP3, and IL-10 expression after the treatment ( p = 0.007, p < 0.0001, and p = 0.002). Overall, our meta-analysis suggests that the Tregs play a crucial role in pathogenesis and progression of vitiligo, and hence, Treg-based therapeutic interventions could be effective in vitiligo patients.

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