Effect of narrowband ultraviolet B phototherapy on melanocytic naevi

Lin, Chien-Te; Oakley, Amanda; Rademaker, Marius; Hill, Sarah; Yung, Anthony

doi:10.1111/bjd.12168

Cited by 6 publications

(11 citation statements)

References 10 publications

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“…Dermoscopically 62% of our studied nevi became darker in color, and this agreed with others [1,10,11,12]. An increase in the thickness of pigment network lines was observed in 44% of reticular nevi, and this agreed with the findings of Manganoni et al [1].…”

Section: Discussionsupporting

confidence: 93%

“…An increase in the thickness of pigment network lines was observed in 44% of reticular nevi, and this agreed with the findings of Manganoni et al [1]. Blurring which is defined as merging of a network and its replacement by a structureless pattern was observed in 46% of reticular nevi, and this agreed with others [11,12]. Globular nevi in this study showed an increase in the number and size of dots/globules, and this agreed with previous reports [1,10,11,12].…”

Section: Discussionsupporting

confidence: 90%

“…Blurring which is defined as merging of a network and its replacement by a structureless pattern was observed in 46% of reticular nevi, and this agreed with others [11,12]. Globular nevi in this study showed an increase in the number and size of dots/globules, and this agreed with previous reports [1,10,11,12]. These morphological and dermoscopic changes could be explained by the redistribution or increase in the melanin content [1].…”

Section: Discussionsupporting

confidence: 89%

“…Examining histopathological and immunohistochemical changes in melanocytes exposed to UVR found significant changes in many studies [12,15,16,17]. In this study, we did not evaluate histological changes but these previously reported changes might account for the increased color intensity, increased size/number of dots, and the enlargement observed dermoscopically in our study.…”

Section: Discussionmentioning

confidence: 63%

“…Lin et al [12] demonstrated that truncal nevi were more likely to increase in size, and this was explained by the variation in UVR sensitivity at different body sites.…”

Section: Discussionmentioning

confidence: 99%

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Dermoscopic and Immunohistochemical Changes in Acquired Melanocytic Nevi following Narrow-Band Ultraviolet B Therapy

Zaher

Bassiouny²,

Hay³

et al. 2016

Dermatology

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Background: Acquired melanocytic nevi (AMN) have been reported to undergo morphological and dermoscopic changes following exposure to narrow-band ultraviolet B (NB-UVB) radiation. Objective: To study the morphological, dermoscopic and immunohistochemical changes in AMN following NB-UVB radiation. Methods: Suberythemogenic NB-UVB sessions were delivered to 40 patients with AMN. For each patient, a minimum of 2 nevi were selected. One nevus was surgically removed from each patient prior to sessions as control; for the other nevus, dermoscopic images were captured before and after NB-UVB sessions. The images were evaluated for changes. At the end, another nevus was surgically removed for immunohistochemical assessment of Ki-67 and melan-A. Results: Our study showed a statistically significant increase in the size of AMN following NB-UVB radiation. Benign dermoscopic changes were observed. Statistically significant positive correlations were found between some dermoscopic findings and the total cumulative dose of NB-UVB. Immunohistochemical analysis did not show any significant change in the exposed AMN. Conclusion: AMN irradiated with repeated suberythemogenic doses of NB-UVB showed benign morphological and dermoscopic changes, and this was confirmed by our immunohistochemical study.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 63%

“…Lin et al [12] demonstrated that truncal nevi were more likely to increase in size, and this was explained by the variation in UVR sensitivity at different body sites.…”

Section: Discussionmentioning

confidence: 99%

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