Effect Of Nasal Continuous Positive Airway Pressure On Global Right Ventricular Myocardial Performance In Patients With Obstructive Sleep Apnea Syndrome

Right Ventricular Remodeling and Dysfunction in Obstructive Sleep Apnea: A Systematic Review of the Literature and Meta-Analysis

“…In the control groups, OSA was excluded based on polysomnography in 18 studies. In 7 studies, healthy control subjects were enrolled based on the absence of clinical symptoms of sleepiness [ 17 , 19 , 20 , 25 , 29 , 31 ] or cardiovascular diseases [ 39 ]. For the assessment of RV remodeling, 16 studies (64%) used RVID and 9 studies (36%) used RVWT.…”

“…However, heterogeneity is to be expected given the variety of studies conducted by different teams at various geographic locations, the variation in disease severity, and differences in the patient populations. In most studies, the investigators were blinded to the participants' study group status [ 15 , 16 , 21 – 27 , 29 , 31 , 33 – 35 , 38 , 39 ]. In addition, interobserver agreement and intraobserver reproducibility were assessed in most of the studies [ 15 , 16 , 21 , 23 – 25 , 27 , 29 , 33 , 36 , 38 , 39 ].…”

“…Conventional echocardiography and pulsed-wave TDI allow for the assessment of RV function by quantifying RV FAC, MPI, TAPSE, and RV S'. Several studies exploiting conventional echocardiography and tissue Doppler imaging have reported that OSA patients frequently present structural and functional alterations of the right ventricle [ 16 – 21 , 23 , 24 , 26 , 29 , 31 – 36 , 38 ]. In contrast, other studies did not reveal any changes in RV morphology and function in OSA patients by the application of conventional echocardiography and TDI [ 15 , 22 , 25 , 27 , 30 , 37 , 39 ].…”

“…Therefore, in clinical practice, ventricular structure and function are commonly assessed using echocardiography. In recent years, several echocardiographic studies have reported that OSA patients frequently present structural and functional alterations of the right ventricle [ 16 – 21 , 23 , 24 , 26 , 29 , 31 – 36 , 38 ]. However, since most of the studies were small and assessed few echocardiographic parameters, the outcomes from these studies have been inconsistent.…”