Effect of nasal continuous positive airway pressure (CPAP) on auditory P300 in obstructive sleep apnea syndrome (OSAS)

El-Gharib, Amani Mohamed; Sharsher, Ragia Samir

doi:10.1016/j.ejenta.2016.10.001

Cited by 4 publications

(5 citation statements)

References 14 publications

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“…Lower amplitude values were correlated with executive impairment even in very early stages (Wong et al, 2006;Gelir et al, 2014;Yerlikaya et al, 2018) as well as with impaired attention (Vakulin et al, 2014). El-Gharib and Sharsher (2017) found increased executive performance, as well as shorter P300 latency and increased amplitude, after 3 months of regular CPAP use by OSAS patients, though their results remained below the scores of healthy controls. Ak et al (2017) found a similar result when comparing OSAS patients' score post-treatment with their pre-CPAP scores, and when comparing both pre-and post-CPAP scores to age and gender matched controls.…”

Section: Obstructive Sleep Apneamentioning

confidence: 96%

Impairment of executive functions due to sleep alterations: An integrative review on the use of P300

2022

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ObjectiveCognitive impairment due to sleep deprivation (SD) is an important global health concern as part of the growing rates of sleep disorders and sleep deprivation worldwide. Amongst the affected cognitive processes, the effects of SD on the executive functions (EFs) show diverse methods and inconclusive or contradictory results, highlighting the importance of further research in this field. Considering this scenario, we evaluate one of the most used methods for objectively evaluating EFs on SD: the event-related potential (ERP) P300.MethodsOur study provides a comprehensive review on the use of P300 for evaluating executive functions in sleep alterations on subjects of all ages, as well as an analysis on the efficiency of P300 as an assessment method for executive functions compared to traditional neurocognitive batteries. We review the benefits of P300 application for multiple sleep/wake alterations, whether evoked in laboratory or as part of pre-existing sleep disorders.ResultsWe assess the diverse protocols used to elicit and complement P300, the most identified alterations in amplitude and latency, and suggest new lines of study that could benefit from P300 within the field.ConclusionWe conclude that P300 is a valuable asset for evaluating executive dysfunction under sleep deprivation both as a standalone protocol and in conjunction with subjective methods, with consistently significant results in assessing executive dysfunction in a diversity of subjects and etiologies.

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Section: Obstructive Sleep Apneamentioning

confidence: 96%

Impairment of executive functions due to sleep alterations: An integrative review on the use of P300

2022

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“…In a study on 20 patients with OSA, El Gharib et al investigated the influence of CPAP on cognitive functions. The results of that study showed a significant difference in latency and amplitude before and after CPAP use ( 14 ).…”

Section: Discussionmentioning

confidence: 94%

“…Untreated OSA is related to hypertension, arrhythmias, congestive heart failure, coronary heart disease, diabetes mellitus, hyperlipidemia, stroke, depression, and cognitive decline [3][4][5][6] . OSA and cognitive functions have been investigated in multiple studies which have reported a certain level of cognitive dysfunction in patients with OSA [7][8][9][10][11][12][13][14] .…”

Section: Introductionmentioning

confidence: 99%

Influence of Continuous Positive Airway Pressure Treatment on Auditory Event-Related Potentials P300

Jurić

2022

ACC

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SUMMARY Obstructive sleep apnea (OSA) is a sleep-related breathing disorder characterized by obstructions of the upper airway during sleep, resulting in repetitive breathing pauses accompanied by oxygen desaturation and arousal from sleep. OSA can be successfully treated with continuous positive airway pressure (CPAP), weight loss, positional therapy, oral appliances, hypoglossal nerve stimulation, and surgical procedures. It has been observed that untreated OSA is related to chronic disorders including hypertension, arrhythmias, congestive heart failure, coronary heart disease, diabetes mellitus, hyperlipidemia, stroke, depression, and cognitive decline. Event-related potentials (ERPs) is the procedure that has been widely used for evaluating cognitive brain functions. Using auditory event-related potentials (P300), this study aimed to examine the effect of CPAP therapy on cognitive functions in patients with moderate and severe OSA. The results of the study showed improvement in P300 latency and amplitude after 3 months of CPAP therapy, indicating a positive effect of CPAP therapy in the prevention of cognitive decline in patients with OSA.

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“…Nocturnal hypoxia and sleep disorder are the main factors of cognitive dysfunction in patients with OSAHS. EL-Gharib (20). As a result, the severity of OSAHS was reduced and the cognitive function of patients with moderate-to-severe OSAHS was improved, but it did not recover to the normal level.…”

Section: Discussionmentioning

confidence: 99%

“…From the labyrinthine artery to the inner ear, the labyrinthine artery can be divided into the anterior vestibular artery and the common cochlear artery. The common cochlear artery branches into the vestibular cochlear artery and cochlear aorta (20). The main control range of the cochlear aorta includes three quarters of the cochlear and the cochlear axis.…”

Section: Discussionmentioning

confidence: 99%

Clinical case control study analysis of vestibular function in patients with obstructive sleep apnea-hypopnea syndrome

Li¹,

Chen²,

Liang³

et al. 2022

Ann Palliat Med

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Background: To investigate the effects of hypoxia degree and sleep duration on vestibular function in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients. We made further study the low oxygen levels of OSAHS and hypoxic duration on the impact of vestibular function, and further studied the OSAHS the longest apnea time and Vestibular Evoked Myogenic Potential (VEMP) abnormal rate and the relationship between the vestibular function of canal paralysis (CP).Methods: A total of 87 OSAHS patients and 47 healthy individuals were enrolled in this study. There was no difference in gender, age and BMI values in matched experimental groups. Exclude other diseases of other system. All the participants completed sleepiness questionnaires (i.e., the Epworth sleepiness scale and the STOP-BANG questionnaire) and the Dizziness Handicap Inventory (DHI). Additionally, a caloric test, positional test, electrocochleogram, and VEMP test were administered to evaluate the vestibular function of all the participants. A polysomnography (PSG) was also performed. Results:The current investigation generated the following three major findings: (I) there was a significant correlation between body mass index and canal paresis [CP; P=0.014, odds ratio (OR) =1.791, 95% confidence interval (CI): 1.125-2.851] and a significant positive correlation between the DHI score and VEMP results (P=0.0061, OR =3.667, 95% CI: 1.449-9.276); (II) the CP abnormality rate of the OSAHS group was significantly higher than that of the control group (P<0.05); (III) there was a significant correlation between the longest apnea duration and the DHI score (r=-0.191, P<0.05). Conclusions:The abnormality rate of the vestibular function of OSAHS patients is higher than that of healthy people. OSAHS intermittent hypoxia can affect vestibular function in the inner ear, and the longer the duration of prolonged hypoxia, the more serious the vestibular function damage.

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Effect of nasal continuous positive airway pressure (CPAP) on auditory P300 in obstructive sleep apnea syndrome (OSAS)

Cited by 4 publications

References 14 publications

Impairment of executive functions due to sleep alterations: An integrative review on the use of P300

Impairment of executive functions due to sleep alterations: An integrative review on the use of P300

Influence of Continuous Positive Airway Pressure Treatment on Auditory Event-Related Potentials P300

Clinical case control study analysis of vestibular function in patients with obstructive sleep apnea-hypopnea syndrome

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