Effect of Nasal Continuous Positive Airway Pressure Treatment on Plasma Adrenomedullin Levels in Patients with Obstructive Sleep Apnea Syndrome: Roles of Nocturnal Hypoxia and Oxidant Stress

Yamamoto, Hiroshi; Teramoto, Shinji; Yamaguchi, Yasuhiro; Ouchi, Yasuyoshi

doi:10.1291/hypres.30.1065

Cited by 13 publications

(10 citation statements)

References 40 publications

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“…Studies on SA treatment have indicated that continuous positive airway pressure (CPAP) therapy can effectively reduce SA nocturnal hypoxia and its associated co-morbidity [35]. If overnight hypoxia in SA patients plays a major role in increased risk of BPH during follow-up, treatment such as CPAP might decrease the risk of BPH in SA patients.…”

Section: Discussionmentioning

confidence: 99%

Increased Risk of Benign Prostate Hyperplasia in Sleep Apnea Patients: A Nationwide Population-Based Study

et al. 2014

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BackgroundSleep apnea (SA) is a common sleep disorder characterized by chronic intermittent hypoxia (IH). Chronic IH induces systemic inflammatory processes, which can cause tissue damage and contribute to prostatic enlargement. The purpose of this study was to evaluate the association between benign prostate hyperplasia (BPH) and SA in a Taiwanese population.MethodsThe study population was identified from Taiwan’s National Health Insurance Research Database (NHIRD) and contained 202 SA patients and 1010 control patients. The study cohort consisted of men aged ≥30 years who were newly diagnosed with SA between January 1997 and December 2005. Each patient was monitored for 5 years from the index date for the development of BPH. A Cox regression analysis was used to calculate the hazard ratios (HRs) for BPH in the SA and control patients.ResultsDuring the 5-year follow-up, 18 SA patients (8.9%) and 32 non-SA control patients (3.2%) developed BPH. The adjusted HR for BPH was 2.35-fold higher in the patients with SA than in the control patients (95% confidence interval (CI) 1.28–4.29, P<.01). We further divided the SA patients into 4 age groups. After adjusting for potential confounding factors, the highest adjusted HR for BPH in the SA patients compared with the control patients was 5.59 (95% CI = 2.19–14.31, P<.001) in the patients aged between 51 and 65 years.ConclusionOur study results indicate that patients with SA are associated with increased longitudinal risk of BPH development, and that the effects of SA on BPH development are age-dependent.

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Section: Discussionmentioning

confidence: 99%

Increased Risk of Benign Prostate Hyperplasia in Sleep Apnea Patients: A Nationwide Population-Based Study

et al. 2014

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“…Molecules or proteins that have been reported include leptin, intercellular and vascular adhesion molecule, L-selectin, E-selectin, interleukin-8, monocyte chemoattractant protein-1, NF-kappaB, and endothelin-1 [1,[4][5][6][7][8][9]. Nasal continuous positive airway pressure (CPAP) treatment decreases sleep apneas, nocturnal oxyhemoglobin desaturation, circulating adrenomedullin, and leukocyte production of reactive oxygen species (ROS) in OSA patients [10]. Effective uvulopalatopharyngoplasty decreases nitric oxide derivative levels [11].…”

Section: Discussionmentioning

confidence: 99%

Analysis of genetic expression in the soft palate of patients with obstructive sleep apnea

Song

Rhee

Min

et al. 2012

Acta Oto-Laryngologica

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Of the 45,034 genes analyzed, 137 were up-regulated in OSA patients compared with simple snorers and 95 were down-regulated. Gene network analysis showed that genes related to RNA interference and transcription were most commonly involved in the functional pathophysiology of OSA. In particular, genes encoding proliferating cell nuclear antigen and proteasome 26S subunit ATPase 6 were functionally connected with other genes.

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“…Cardiovascular risk profiles, such as inflammatory markers in children [11,12], abnormal lipid metabolism in obese children [7••], and markers related to the development of hypertension in adults [13] reversed after treatment of SDB. QOL after treatment also improves in children with SDB, as does school performance [8••,14,15].…”

Section: The Reason To Treatmentioning

confidence: 99%

“…Hypoxemia is suggested to play a key role not only in the development of cardiovascular disorders [13] associated with SDB but also in the neuropsychological and neuronal injury associated with SDB [6]. A study comparing oxygen therapy with CPAP or placebo in 38 sleep apnea patients demonstrated significant reductions in general psychological symptoms with oxygen therapy or CPAP but not placebo; however, depression improved with oxygen and not CPAP or placebo, indicating that hypoxemia plays an important role in some symptoms occurring with SDB [78•].…”

Section: Treatment Of Blood Gas Abnormalities In Sleep-disordered Brementioning

confidence: 99%

Treatment alternatives for sleep-disordered breathing in the pediatric population

Halbower

McGinley²,

Smith³

2008

Current Opinion in Pulmonary Medicine

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Purpose for review-Childhood sleep-disordered breathing (SDB) is associated with a myriad of health problems that underscore the need for early diagnosis and treatment. Children with SDB present with behavior problems, deficits of general intelligence, learning and memory deficits, evidence of brain neuronal injury, increased cardiovascular risk, and poor quality of life. Children are in a rapid state of cognitive development, therefore, alterations of health and brain function associated with SDB could permanently alter a child's social and economic potential; especially if the disorder is not recognized early in life or is treated inadequately.Recent findings-There is evidence that the majority of the problems associated with SDB improve with treatment. Treatment strategies are now being aimed at mechanisms underlying the disorder. There are multiple treatment options available to children; some are novel, with pending treatments on the horizon that may replace age-old therapies such as adenotonsillectomy or nasal positive pressure.Summary-It is imperative that healthcare workers actively seek out signs and symptoms of SDB in patients to improve early detection and treatment for prevention of long-term morbidity.

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Effect of Nasal Continuous Positive Airway Pressure Treatment on Plasma Adrenomedullin Levels in Patients with Obstructive Sleep Apnea Syndrome: Roles of Nocturnal Hypoxia and Oxidant Stress

Cited by 13 publications

References 40 publications

Increased Risk of Benign Prostate Hyperplasia in Sleep Apnea Patients: A Nationwide Population-Based Study

Increased Risk of Benign Prostate Hyperplasia in Sleep Apnea Patients: A Nationwide Population-Based Study

Analysis of genetic expression in the soft palate of patients with obstructive sleep apnea

Treatment alternatives for sleep-disordered breathing in the pediatric population

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