Effect of nasal polivalent bacterial lysate on the clinical course of seasonal allergic rhinitis in children - preliminary study

Kowalska, Magdalena; Emeryk, Andrzej; Janeczek, Kamil; Pawluk, Iwona Czerwińska

doi:10.1183/13993003.congress-2020.1208

Cited by 2 publications

(5 citation statements)

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“…One study 20 fall to the low risk of bias, two studies 15 , 17 to the unclear and three studies 16 , 18 , 19 to the high risk of bias. The risk of bias summaries and graph are presented in Figures 2 and 3 , respectively.…”

Section: Resultsmentioning

confidence: 99%

“…The conducted literature search resulted in three studies concerning the use of PCBLs in AR. 16 , 17 , 19 …”

Section: Resultsmentioning

confidence: 99%

“…The databases search provided only one study that evaluated the effect of intranasally applied PCBL on the clinical course of SAR in children. 19 For first 6 weeks of the grass pollen season, 18 patients took intranasal PCBL in addition to standard AR therapy, while the remaining 22 took placebo. Nasal and ocular symptom severity was assessed at the beginning of the study and at the end of therapy using standard scoring scales (TNSS, TOSS, VAS) and objective methods (PNIF measurement).…”

Section: Resultsmentioning

confidence: 99%

“… 15 , 17 , 18 , 20 The most common adverse event was abdominal pain, which occurred with similar frequency to the placebo group. 17 , 20 Although one study 19 demonstrated a small effect of BLs on improving the clinical course of AR, given the high safety of these agents, their addition to standard therapy should be considered.…”

Section: Discussionmentioning

confidence: 99%

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Perspectives for the Use of Bacterial Lysates for the Treatment of Allergic Rhinitis: A Systematic Review

Janeczek¹,

Kaczyńska²,

Emeryk³

et al. 2022

JAA

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Bacterial lysates (BLs) are mixtures of bacterial antigens that have been used for many decades to minimize the risk of recurrent respiratory tract infections in both pediatric and adult populations. Research on the use of BLs is also conducted in allergology. Biomedical databases were searched for articles on the use of BLs in the treatment of allergic rhinitis (AR). After rejecting ineligible articles, six remaining reports were reviewed. Based on this review, it can be concluded that adding BL to standard therapy for seasonal or perennial AR reduces the severity of nasal symptoms and the need for antiallergic medications in both children and adults. Concurrently, these formulations have a high safety profile. An analysis of studies shows that the first effects of BLs therapy appear at the earliest 2–6 weeks after the start of treatment and persist at least 3 months after treatment.

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Section: Resultsmentioning

confidence: 99%

“…The conducted literature search resulted in three studies concerning the use of PCBLs in AR. 16 , 17 , 19 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Perspectives for the Use of Bacterial Lysates for the Treatment of Allergic Rhinitis: A Systematic Review

Janeczek¹,

Kaczyńska²,

Emeryk³

et al. 2022

JAA

Self Cite

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“…Intranasal polyvaccinium mite (a PCBL consisting of S. aureus , Staphylococcus epidermidis , Streptococcus salivarius , S. pneumoniae , S. pyogenes , Escherichia coli , K. pneumoniae , H. influenzae , Corynebacterium pseudodiphtheriticum , and M. catarrhalis ) added to standard antiallergy treatment during grass pollen season does not improve the process AR in children but significantly increased peak nasal inspiratory flow ( p =0.01) and decreased nasal symptoms on the visual analog scale ( p =0.03) compared to placebo [ 76 ] ( Table 1 ).…”

Section: Successful Immunotherapeutic Bacterial Lysates For Infectiou...mentioning

confidence: 99%

Advances in Bacterial Lysate Immunotherapy for Infectious Diseases and Cancer

Rahman,

Grice,

Ulett

et al. 2024

Journal of Immunology Research

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Antigenic cell fragments, pathogen‐associated molecular patterns, and other immunostimulants in bacterial lysates or extracts may induce local and systemic immune responses in specific and nonspecific paradigms. Based on current knowledge, this review aimed to determine whether bacterial lysate has comparable functions in infectious diseases and cancer treatment. In infectious diseases, including respiratory and urinary tract infections, immune system activation by bacterial lysate can identify and combat pathogens. Commercially available bacterial lysates, including OM‐85, Ismigen, Lantigen B, and LW 50020, were effective in children and adults in treating respiratory tract infections, chronic obstructive pulmonary disease, rhinitis, and rhinosinusitis with varying degrees of success. Moreover, OM‐89, Uromune, Urovac, Urivac, and ExPEC4V showed therapeutic benefits in controlling urinary tract infections in adults, especially women. Bacterial lysate‐based therapeutics are safe, well‐tolerated, and have few side effects, making them a good alternative for infectious disease management. Furthermore, a nonspecific immunomodulation by bacterial lysates may stimulate innate immunity, benefiting cancer treatment. “Coley’s vaccine” has been used to treat sarcomas, carcinomas, lymphomas, melanomas, and myelomas with varying outcomes. Later, several similar bacterial lysate‐based therapeutics have been developed to treat cancers, including bladder cancer, non‐small cell lung cancer, and myeloma; among them, BCG for in situ bladder cancer is well‐known. Proinflammatory cytokines, including IL‐1, IL‐6, IL‐12, and TNF‐α, may activate bacterial antigen‐specific adaptive responses that could restore tumor antigen recognition and response by tumor‐specific type 1 helper cells and cytotoxic T cells; therefore, bacterial lysates are worth investigating as a vaccination adjuvants or add‐on therapies for several cancers.

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Effect of nasal polivalent bacterial lysate on the clinical course of seasonal allergic rhinitis in children - preliminary study

Cited by 2 publications

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Perspectives for the Use of Bacterial Lysates for the Treatment of Allergic Rhinitis: A Systematic Review

Perspectives for the Use of Bacterial Lysates for the Treatment of Allergic Rhinitis: A Systematic Review

Advances in Bacterial Lysate Immunotherapy for Infectious Diseases and Cancer

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