Effect of nasolacrimal duct obstruction on nasal mucociliary transport

Naiboğlu, Barış; Deveci, İldem; Kalaycık, Çiğdem; Daylan, A; Habesoglu, Tulay Erden; Toros, Sema Zer; Deveci, Senem; Egeli, Erol

doi:10.1017/s0022215109991058

Cited by 6 publications

(3 citation statements)

References 28 publications

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“…Since then, the STT technique has been used in several studies involving MCC, 12 22 24 25 28 either to characterize different populations 11 21 22 29 30 or to evaluate the effect of interventions such as the use of anesthetics, 31 32 continuous positive airway pressure (CPAP), 5 33 and smoking cessation. 34…”

Section: Review Of a Particular Subjectmentioning

confidence: 99%

“…The STT is a useful method for scientific research, widely used in nasal MCC studies, as it is a reproducible, 18 20 21 simple to perform, and noninvasive technique, besides being low-cost, making it an interesting alternative to other methods that require relatively complex, invasive, and expensive equipment, and demand greater technical aptitude from the examiners. 12 22 23 24 25 26…”

Section: Introductionmentioning

confidence: 99%

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Particularities and Clinical Applicability of Saccharin Transit Time Test

Rodrigues

Freire

Uzeloto

et al. 2019

Int Arch Otorhinolaryngol

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Introduction The importance of mucociliary clearance (MCC) for the respiratory system homeostasis is clear. Therefore, evaluating this defense mechanism is fundamental in scientific research and in the clinical practice of pulmonology and of associated areas. However, MCC evaluation has not been so usual due to the complexity of methods that use radiolabeled particles. Nevertheless, as an interesting alternative, there is the saccharin transit time (STT) test. This method is reproducible, simple to perform, noninvasive, does not demand high costs, and has been widely used in studies of nasal MCC. Although the STT test is widely used, there is still lack of a detailed description of its realization. Objective The present literature review aims to provide basic information related to the STT test and to present the findings of the previous studies that used this method, discussing variations in its execution, possible influences on the obtained results and limitations of the method, as well as to relate our experience with the use of STT in researches. Data Synthesis There are several factors that can alter the results obtained from STT tests, which would raise difficulties with proper interpretation and with the discussion of the results among different studies. Conclusions Saccharin transit time is a widely used method for the evaluation of nasal MCC, and therefore, the standardization related to the previous and concurrent to test orientations, and also its execution, become essential to improve its accuracy, and allow comparisons among different studies.

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Section: Review Of a Particular Subjectmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Particularities and Clinical Applicability of Saccharin Transit Time Test

Rodrigues

Freire

Uzeloto

et al. 2019

Int Arch Otorhinolaryngol

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“…The STT test was first described in 1974 by Anderson et al [39]. It is a method for scientific research widely used to assess nasal mucociliary clearance as it is reproducible, simple and noninvasive, besides being low cost [15,[40][41][42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Correlation between Upper Airway and Lower Airway Function in Current Smokers, Never Smokers and Former Smokers

Ravi

Pal

Kumar

et al. 2023

JAMMR

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Introduction: Smoking is the major risk factor for the development of chronic lung disease and airway malignancy. The development of biomarkers for disease onset and early progression is hindered by the accessibility of the primary tissue in the lungs, so there is a need to evaluate alternative sites for surrogate biomarkers. The harmful effects seen in the lower and distal airways are also mirrored in the nasal epithelium as one airway and one disease. Objective: To study the correlation between nasal mucosal cytology, mucociliary function, nasal airflow and lung function among the current smokers, never smokers, and former smokers. Methods: Cross sectional, observational study from a tertiary care hospital.105 subjects were randomly distributed on the basis of smoking pattern into 3 groups, never smoker, current smoker and former smoker. Nasal mucosal cytology and function were assessed by saccharin transit time test (STT), peak nasal inspiratory flow(PNIF) and nasal ciliated cells & goblet cell ratio. The lower airway was assessed by spirometry. Results: The increase in saccharin transit time was statistically significant (p <.001) in current smokers and former smokers compared to never smokers. The lower mean goblet cell count of the former smoker group was statistically significant when compared to the never smoker and current smoker groups, (p.023) while the change in ciliated cell/ goblet cell ratio remained statistically insignificant. The decrease in FEV1/FVC is statistically significant (p 0.036) in former smokers compared to both never smokers and current smokers. Conclusion: Nasal mucociliary function is reduced in smokers and this reduction is permanent as cessation of smoking does not improve the mucociliary function. Lay Summary: The study is focused to find out whether harmful effects seen in the lower and distal airways are also mirrored in the nasal epithelium as one airway and one disease in current smokers, never smokers and former smokers and thus to find out an early predictor of chronic lung disease so that intervention may be initiated to counsel and help the smokers taking part in the study to quit smoking. It was a Cross sectional, observational study from a tertiary care hospital.105 subjects were randomly distributed on the basis of smoking pattern into 3 groups, never smoker, current smoker and former smoker. Nasal mucosal cytology and function were assessed by saccharin transit time test (STT), peak nasal inspiratory flow (PNIF) and nasal ciliated cells & goblet cell ratio (CC/GC). Lower airway was assessed by spirometry.The increase in saccharin transit time is statistically significant (p <.001) in current smoker and former smoker compared to never smoker which implied that nasal mucociliary function is reduced in smokers. The lower mean goblet cell count of the former smoker group was statistically significant when compared to the never smoker and current smoker groups. (p.023) while the changes in ciliated cell and goblet cell ratio remained statistically insignificant. The decrease in FEV1/FVC is statistically significant (p 0.036) in former smokers compared to both never smokers and current smoker which lead us to the conclusion that this reduction is permanent and cessation of smoking does not improve the mucociliary function.

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