Effect of natural leaf extracts as phytomedicine in curing geriatrics

Bhattacharya, Tanima; Dey, Protity Shuvra; Akter, Rokeya; Kabir, Md. Tanvir; Rahman, Md. Habibur; Rauf, Abdur

doi:10.1016/j.exger.2021.111352

Cited by 33 publications

(20 citation statements)

References 84 publications

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“…Neuroinflammation mediated primarily by resident brain microglia has gained attention from researchers as both an important mediator of the dopaminergic neuron loss in PD and an attractive drug target for neurodegenerative disease therapy [ 102 , 103 , 104 , 105 ]. Microglia are the cells responsible for mediating the innate immune response in the brain through antigen-presenting and effector functions such as phagocytosis [ 106 ].…”

Section: Role Of Ferroptosis In Microglia/macrophage M1/m2 Polarizationmentioning

confidence: 99%

Ferroptosis as a Major Factor and Therapeutic Target for Neuroinflammation in Parkinson’s Disease

Gao

Lin

et al. 2021

Biomedicines

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Mounting evidence suggests that ferroptosis is not just a consequence but also a fundamental contributor to the development and progression of Parkinson’s disease (PD). Ferroptosis is characterized as iron-dependent regulated cell death caused by excessive lipid peroxidation, leading to plasma membrane rupture, release of damage-associated molecular patterns, and neuroinflammation. Due to the crucial role of intracellular iron in mediating the production of reactive oxygen species and the formation of lipid peroxides, ferroptosis is intimately controlled by regulators involved in many aspects of iron metabolism, including iron uptake, storage and export, and by pathways constituting the antioxidant systems. Translational and transcriptional regulation of iron homeostasis and redox status provide an integrated network to determine the sensitivity of ferroptosis. We herein review recent advances related to ferroptosis, ranging from fundamental mechanistic discoveries and cutting-edge preclinical animal studies, to clinical trials in PD and the regulation of neuroinflammation via ferroptosis pathways. Elucidating the roles of ferroptosis in the survival of dopaminergic neurons and microglial activity can enhance our understanding of the pathogenesis of PD and provide opportunities for the development of novel prevention and treatment strategies.

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Section: Role Of Ferroptosis In Microglia/macrophage M1/m2 Polarizationmentioning

confidence: 99%

Ferroptosis as a Major Factor and Therapeutic Target for Neuroinflammation in Parkinson’s Disease

Gao

Lin

et al. 2021

Biomedicines

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“…Chemically, they act as antioxidants and, physically, as membrane stabilizers [47]. A wide variety of phytosterols are present in the diet, but the most abundant ones are β-sitosterol, camp sterols, ergosterols, and stigma sterols [48,49]. AMP-activated protein kinase (AMPK) is a unique target for treating many forms of cancer, including BC; it acts as a sensor of cellular energy stress, thereby promoting cellular catabolic pathways and inhibiting cellular anabolic pathways, growth, and proliferation.…”

Section: Phytosterolmentioning

confidence: 99%

Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer

et al. 2021

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Breast cancer (BC) is one of the most common type of cancer and an important contributor to female mortality. Several genes and epigenetic modifications are involved in the development and progression of BC. Research in phytochemistry, nutrigenomics, and nutrigenetics has provided strong evidence that certain phytonutrients are able to modulate gene expression at transcriptional and post-transcriptional levels. Such phytonutrients may also be beneficial to prevent and treat BC. In this review, we will focus on the nutrigenomic effects of various phytochemicals including polyphenols, phytosterols, terpenoids, alkaloids, and other compounds from different sources. Overall, these phytonutrients are found to inhibit BC cell proliferation, differentiation, invasion, metastasis, angiogenesis, and induce apoptotic cell death by targeting various molecular pathways. They also alter epigenetic mechanisms and enhance the chemosensitivity and radiosensitivity of cancer cells. Such phytochemicals may be used for the effective management of BC patients in the clinical setting in the future. The present article aims to summarize the specific molecular pathways involved in the genetic effects of phytochemicals in BC.

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“…For example, riboflavin administration leads to the generation of FRs in vitro, which causes oxidative damage and ultimately leads to neurite degeneration (Lucius et al 1998;Rahman et al 2021a). The possible mechanism of FR-induced neurite damage is due to the activation of N-methyl-D-aspartate (NMDA) receptors and an increase in the cytosolic Ca 2+ concentration (Bhattacharya et al 2021a). Studies also demonstrated the neuroprotective function of fibroblast growth factor 10 (FGF10) and nerve growth factor (NGF) in axonal regeneration after the brain and the spinal cord injury.…”

Section: Axonal Regenerationmentioning

confidence: 99%

“…Exposure of skin to UV with oxygen and other biomolecules results in the production of FRs. Thus, their interaction with the biological membrane results in lipid peroxidation (Youn et al 2010;Bhattacharya et al 2021a).…”

Section: Functional Effect Of Environmental Factors and Lifestyle In Free Radical-induced Neurological Diseasesmentioning

confidence: 99%

Free radical biology in neurological manifestations: mechanisms to therapeutics interventions

Tripathi

Gupta

Sahu

et al. 2021

Environ Sci Pollut Res

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Recent advancements and growing attention about free radicals (ROS) and redox signaling enable the scientific fraternity to consider their involvement in the pathophysiology of inflammatory diseases, metabolic disorders, and neurological defects. Free radicals increase the concentration of reactive oxygen and nitrogen species in the biological system through different endogenous sources and thus increased the overall oxidative stress. An increase in oxidative stress causes cell death through different signaling mechanisms such as mitochondrial impairment, cell-cycle arrest, DNA damage response, inflammation, negative regulation of protein, and lipid peroxidation. Thus, an appropriate balance between free radicals and antioxidants becomes crucial to maintain physiological function. Since the 1brain requires high oxygen for its functioning, it is highly vulnerable to free radical generation and enhanced ROS in the brain adversely affects axonal regeneration and synaptic plasticity, which results in neuronal cell death. In addition, increased ROS in the brain alters various signaling pathways such as apoptosis, autophagy, inflammation and microglial activation, DNA damage response, and cell-cycle arrest, leading to memory and learning defects. Mounting evidence suggests the potential involvement of micro-RNAs, circular-RNAs, natural and dietary compounds, synthetic inhibitors, and heat-shock proteins as therapeutic agents to combat neurological diseases. Herein, we explain the mechanism of free radical generation and its role in mitochondrial, protein, and lipid peroxidation biology. Further, we discuss the negative role of free radicals in synaptic plasticity and axonal regeneration through the modulation of various signaling molecules and also in the involvement of free radicals in various neurological diseases and their potential therapeutic approaches.

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Effect of natural leaf extracts as phytomedicine in curing geriatrics

Cited by 33 publications

References 84 publications

Ferroptosis as a Major Factor and Therapeutic Target for Neuroinflammation in Parkinson’s Disease

Ferroptosis as a Major Factor and Therapeutic Target for Neuroinflammation in Parkinson’s Disease

Role of Phytonutrients in Nutrigenetics and Nutrigenomics Perspective in Curing Breast Cancer

Free radical biology in neurological manifestations: mechanisms to therapeutics interventions

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