Effect of natural polyphenols on thromboxane levels in children with Crohn’s disease

Koláček, M; Paduchová, Zuzana; Dvořáková, Monika; Žitňanová, Ingrid; Čierna, Iveta; Ďuračková, Zdeňka; Muchová, Jana

doi:10.4149/bll_2019_155

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…Furthermore, more metabolic pathways were reported when using our optimized metabolomics workflow. The majority of these pathways are biologically meaningful according to previous studies including bile acid [28,29], vitamin E [30], vitamin D3 [31,32], galactose [33], glycerophospholipid [33], fatty acid [29,34], and hyaluronan [35] metabolism pathways. Similarly, other comparisons between the different IBD groups also produced more perturbed metabolic pathways by our optimized workflow in MetaboAnalystR 3.0.…”

Section: Discussionmentioning

confidence: 99%

MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics

et al. 2020

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Liquid chromatography coupled to high-resolution mass spectrometry platforms are increasingly employed to comprehensively measure metabolome changes in systems biology and complex diseases. Over the past decade, several powerful computational pipelines have been developed for spectral processing, annotation, and analysis. However, significant obstacles remain with regard to parameter settings, computational efficiencies, batch effects, and functional interpretations. Here, we introduce MetaboAnalystR 3.0, a significantly improved pipeline with three key new features: (1) efficient parameter optimization for peak picking; (2) automated batch effect correction; and (3) more accurate pathway activity prediction. Our benchmark studies showed that this workflow was 20~100× faster compared to other well-established workflows and produced more biologically meaningful results. In summary, MetaboAnalystR 3.0 offers an efficient pipeline to support high-throughput global metabolomics in the open-source R environment.

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Section: Discussionmentioning

confidence: 99%

MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics

et al. 2020

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“…The result was both a preventive and a curative effect of the polyphenolic extract with the inhibition of body weight loss and colon shortening, reduction in transmural inflammation and acceleration of mucosal healing [ 24 ]. Kolacek et al treated 14 children suffering from CD with a 10-week course of a grapes and pine’s bark extract, called Pycnogenol, and they observed a reduction in the pro-inflammatory thromboxane B2 expression, which was augmented at baseline in CD patients compared to healthy controls [ 25 ]. An extract of olive leaves, containing oleuropeoside and other polyphenols, showed anti-inflammatory effect in intestinal mucosal samples from CD patients [ 26 ], whilst an apple polyphenol extract (APE) improved colon damage in a rat model of colitis by reducing COX-2, TNF-α, calpain and tissue transglutaminase mRNA expression [ 27 ].…”

Section: Phytotherapicsmentioning

confidence: 99%

Nutraceuticals and Diet Supplements in Crohn’s Disease: A General Overview of the Most Promising Approaches in the Clinic

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Chiurazzi

et al. 2022

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Crohn’s disease (CD) is a chronic inflammatory gastrointestinal disorder requiring lifelong medications. The currently approved drugs for CD are associated with relevant side effects and several studies suggest an increased use of nutraceuticals among CD patients, seeking for what is perceived as a more “natural” approach in controlling this highly morbid condition. Nutraceuticals are foods or foods’ components with beneficial health properties that could aid in CD treatment for their anti-inflammatory, analgesic and immunoregulatory activities that come along with safety, high tolerability, easy availability and affordability. Depending on their biological effect, nutraceuticals’ support could be employed in different subsets of CD patients, both those with active disease, as adjunctive immunomodulatory therapies, and/or in quiescent disease to provide symptomatic relief in patients with residual functional symptoms. Despite the increasing interest of the general public, both limited research and lack of education from healthcare professionals regarding their real clinical effectiveness account for the increasing number of patients turning to unconventional sources. Professionals should recognize their widespread use and the evidence base for or against their efficacy to properly counsel IBD patients. Overall, nutraceuticals appear to be safe complements to conventional therapies; nonetheless, little quality evidence supports a positive impact on underlying inflammatory activity.

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“…At baseline, CD patients had significantly higher levels of the static and dynamic forms of thromboxane B2 in comparison to the controls. After 10 weeks, treatment with pycnogenol decreased the level of the dynamic form of thromboxane B2, indicating that pycnogenol administration may positively influence clinical symptoms of CD such as thromboembolic episodes [117]. In a large-scale study of 110 patients with CD (73% women) and 244 patients with ulcerative colitis (57% women), 440 and 976 controls aged 20 to 80 years from eight countries were recruited between 1991 and 1998.…”

Section: Digestive Diseasementioning

confidence: 99%

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

et al. 2021

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Drugs are bioactive compounds originally discovered from chemical structures present in both the plant and animal kingdoms. These have the ability to interact with molecules found in our body, blocking them, activating them, or increasing or decreasing their levels. Their actions have allowed us to cure diseases and improve our state of health, which has led us to increase the longevity of our species. Among the molecules with pharmacological activity produced by plants are the polyphenols. These, due to their molecular structure, as drugs, also have the ability to interact with molecules in our body, presenting various pharmacological properties. In addition, these compounds are found in multiple foods in our diet. In this review, we focused on discussing the bioavailability of these compounds when we ingested them through diet and the specific mechanisms of action of polyphenols, focusing on studies carried out in vitro, in animals and in humans over the last five years. Knowing which foods have these pharmacological activities could allow us to prevent and aid as concomitant treatment against various pathologies.

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Effect of natural polyphenols on thromboxane levels in children with Crohn’s disease

Cited by 4 publications

References 34 publications

MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics

MetaboAnalystR 3.0: Toward an Optimized Workflow for Global Metabolomics

Nutraceuticals and Diet Supplements in Crohn’s Disease: A General Overview of the Most Promising Approaches in the Clinic

Pharmacological Properties of Polyphenols: Bioavailability, Mechanisms of Action, and Biological Effects in In Vitro Studies, Animal Models, and Humans

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