“…Advances in DNA sequencing technologies are revealing a vast genetic heterogeneity in human population, which may predispose to metabolic alterations if the activity of metabolic enzymes is affected [ 1 , 2 , 3 , 4 ]. Mutations and polymorphism may affect several protein functions simultaneously, such as catalysis, regulation, ligand binding, intracellular folding, degradation, aggregation and transport [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ].…”