Effect of neem leaves extract irrigation on the wound healing outcome in nurse managed diabetic foot ulcers

Jayalakshmi, M

doi:10.5455/njppp.2021.10.09238202008092020

Cited by 5 publications

(10 citation statements)

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“…Of these, two articles were separate reports of a single trial 40,63 ; hence, one with limited data was excluded 63 . Additionally, two other articles represented overlapping populations; however, both were included because each reported a different study outcome 64,65 . Accordingly, 28 RCTs that were documented in 29 publications were included.…”

Section: Resultsmentioning

confidence: 99%

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Healing of diabetic foot ulcer with topical and oral administrations of herbal products: A systematic review and meta‐analysis of randomized controlled trials

Zamanifard,

Nasiri,

Yarahmadi

et al. 2024

International Wound Journal

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This systematic review aimed to qualitatively synthesize recent randomized controlled trials (RCTs) regarding the effect of topical application and oral intake of herbal products on the healing of diabetic foot ulcer (DFU). Also, we sought to pool the obtained findings in a meta‐analysis using a random‐effects model, if RCTs were relatively comparable and homogenous. A comprehensive search was performed on five electronic data sources from their inception through 23 January 2024. The RCTs, without restriction on the country of origin, were included if they compared the effect of administering standard treatments and/or placebo (i.e. control condition) to applying standard treatments and/or herbal products in topical or oral routes (i.e. experimental condition). Out of 1166 retrieved records, 28 RCTs were included. Studies used different poly and single herbal formulations. Based on the meta‐analysis, administration of standard care plus daily dressing of the ulcer site with olive oil for 28 days significantly increased the total ulcer healing score (3 RCTs; weighted mean difference [WMD] = 89.30; p < 0.001), raised frequency of complete ulcer healing (2 RCTs; risk ratio [RR] = 12.44; p = 0.039) and declined ulcer degree (3 RCTs; WMD = −22.28; p = 0.002). Also, daily use of the bitter melon leaf extract in oral form for 28 days significantly increased the total ulcer healing score (2 RCTs; WMD = 0.40; p = 0.001). Additionally, based on qualitative synthesis, the adjuvant use of herbal agents seems an intriguing choice to manage DFU. Nonetheless, considering the undesirable methodological quality of most studies and the high heterogeneity in administered herbal formulations, more robust trials are required to build a solid conclusion regarding the use of herbal products for healing DFU.

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Section: Resultsmentioning

confidence: 99%

“…Seven trials reported both CUH and LUH following the administration of a topical product 47,52,56,64,68,69,71 . Likewise, two trials evaluated both CUH and LUH after the intake of an oral supplement 38,57 .…”

Section: Resultsmentioning

confidence: 99%

Healing of diabetic foot ulcer with topical and oral administrations of herbal products: A systematic review and meta‐analysis of randomized controlled trials

Zamanifard,

Nasiri,

Yarahmadi

et al. 2024

International Wound Journal

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“…In LF there are several reports of sustained bacterial infection as cause of chronic wounds in LF pathologies, and this could be mitigated through treatment with P. biglobosa which has been shown to have wound healing activity 46 . Study has also shown that aqueous extracts of neem leaves have wound‐healing ability and this is an appropriate option, preferred for its naturality, ease of access, and is safe, with no known adverse effect 47 . Further investigations into the wound healing abilities of African medicinal plants as cure for LF wounds would bring relief to the debilitating conditions of LE patients with chronic wounds.…”

Section: Prospects Of Medicinal Plants Against Chronic Wounds Among F...mentioning

confidence: 99%

“… 46 Study has also shown that aqueous extracts of neem leaves have wound‐healing ability and this is an appropriate option, preferred for its naturality, ease of access, and is safe, with no known adverse effect. 47 Further investigations into the wound healing abilities of African medicinal plants as cure for LF wounds would bring relief to the debilitating conditions of LE patients with chronic wounds.…”

Section: Prospects Of Medicinal Plants Against Chronic Wounds Among F...mentioning

confidence: 99%

Use of medicinal plants as a remedy against lymphatic filariasis: Current status and future prospect

Fordjour,

Osei‐Poku,

Genfi

et al. 2023

Health Science Reports

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Despite the successes achieved so far with the Global Programme to Eliminate Lymphatic Filariasis, there is still an appreciable number of lymphatic filarial patients who need alternative treatment and morbidity management strategies.The unresponsiveness of some cohorts to the drugs used in the mass drug administration program is currently raising a lot of questions and this needs urgent attention. Natural medicinal plants have a long-standing history of being effective against most disease conditions. Countries such as India have been able to integrate their natural plant remedies into the treatment of lymphatic filarial conditions, and the results are overwhelmingly positive. Components of Azadirachta indica A. Juss, Parkia biglobosa, Adansonia digitata, and Ocimum spp have been shown to have anti-inflammatory, anticancerous, and antimicrobial activities in animal models. Therefore, this review calls for attention toward the use of natural plant components as an alternate treatment against lymphatic filariasis to help reduce the World Health Organization's burden of providing drugs for people in need of treatment every year.

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“…123 Clinical studies showed that A indica inhibits inflammation as effective as cortisone acetate (60th in 10) and irrigation with neem leaf extracts promotes wound healing in the diabetic foot. 124…”

Section: Azadirachta Indicamentioning

confidence: 99%

Challenges and Prospects of Development of Herbal Biomaterial Based Ethical Wound Care Products—A Scoping Review

Jayram

Kondaveeti

Johnson

et al. 2021

The International Journal of Lower Extremity Wounds

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Total wound care is an unmet therapeutic need considering the morbidity and mortality associated with the rising prevalence of nonhealing/chronic wounds. Current wound management fails to address all aspects/types of wounds despite the availability of scores of traditional and modern, investigational products. Traditional medicine drugs of wound healing repute validated to target multiple biological pathways and key events in the mammalian wound healing cascade, reportedly affecting wound healing phases. Advances in the development of biocomposite matrices and their analytical characterization warrant a relook at consolidating time-tested wound healing properties of herbal bioactives for prospective development as ethical wound care products. Aside from the bottlenecks of their multiconstituent profiling and clinical trial data generation, regulatory hurdles also cloister any systematic attempts at their re-engineering into clinical deliverables. In the context of national policy changes to bring in totally indigenous solutions, countries with a huge knowledge/material resource on wound healing bioactives need to essentially facilitate the same.

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Effect of neem leaves extract irrigation on the wound healing outcome in nurse managed diabetic foot ulcers

Cited by 5 publications

References 0 publications

Healing of diabetic foot ulcer with topical and oral administrations of herbal products: A systematic review and meta‐analysis of randomized controlled trials

Healing of diabetic foot ulcer with topical and oral administrations of herbal products: A systematic review and meta‐analysis of randomized controlled trials

Use of medicinal plants as a remedy against lymphatic filariasis: Current status and future prospect

Challenges and Prospects of Development of Herbal Biomaterial Based Ethical Wound Care Products—A Scoping Review

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