Effect of Negative Pressure Wound Therapy on Wound Complications Following Pancreatectomy

Kuncewitch, Michael; Blackham, Aaron U.; Clark, Clancy J.; Dodson, Rebecca M.; Russel, Gregory; Levine, Edward; Shen, Perry

doi:10.1016/s0016-5085(17)34243-9

Cited by 5 publications

(5 citation statements)

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“…Approximately 67 percent of studies (n = 18) were published after 2015. [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Study sample sizes ranged from 11 to 394 participants. A total of 1125 participants received negative-pressure wound therapy and 1392 received standard surgical dressings, but there were only 2468 patients total because 49 patients received both therapies.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

“…Only five studies have recently come out in opposition to it. 17,19,20,26,31 However, their stance was attributable to a lack of significant outcome differences between groups rather than relatively poor outcomes with negative-pressure wound therapy, with one exception in which the negative-pressure wound therapy group malignancy recurrence rate was higher but no p value was reported. 26 The results of our meta-analysis showed statistically significant differences in wound complication and overall surgical site infection rates in favor of negative-pressure wound therapy use over standard surgical dressings.…”

Section: Discussionmentioning

confidence: 98%

“…18,21,22,27,32,34 Our review only contains four randomized controlled trials and is predominantly composed of retrospective chart reviews ( n = 19, 70 percent), which are inherently prone to interpreter, incomplete data collection, and investigator bias. 17–20,23–25,27–42 Some articles reported outcomes using median values; others reported them using mean values. As a result, data reported using median values were excluded from statistical analysis.…”

Section: Discussionmentioning

confidence: 99%

“…18,21,22,27,32,34 Our review only contains four randomized controlled trials and is predominantly composed of retrospective chart reviews (n = 19, 70 percent), which are inherently prone to interpreter, incomplete data collection, and investigator bias. [17][18][19][20][23][24][25][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] Some articles reported…”

Section: Limitationsmentioning

confidence: 99%

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“Negative Pressure Wound Therapy (NPWT) Yields Lower Wound Complication and Surgical Site Infection Rates Compared to Standard Surgical Dressings (SSDs) after Resection of a Malignancy: A Systematic Review and Meta-Analysis”

Hays¹,

Singh²,

Saragossi³

et al. 2022

Plastic &Amp; Reconstructive Surgery

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Background: Negative-pressure wound therapy offers many advantages over standard surgical dressings in the treatment of open wounds, including accelerated wound healing, cost savings, and reduced complication rates. Although contraindicated by device manufacturers in malignancy-resected wounds because of hypothesized risk of tumor recurrence, negative-pressure wound therapy is still applied postoperatively because of limited clinical support. The authors performed a systematic review with meta-analysis to compare negative-pressure wound therapy outcomes with those of standard surgical dressings on open wounds, with their null hypothesis stating there would be no outcome differences. Methods: A systematic review of the literature on negative-pressure wound therapy and standard surgical dressings on malignancy-resected wounds was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using PubMed, Embase, CINAHL, and Cochrane Central databases. Meta-analysis compared group outcomes, including malignancy recurrence, wound complication, and surgical site infection rates, with a random effects model. Results: A total of 1634 studies were identified and 27 met eligibility criteria, including four randomized controlled trials, four prospective cohort studies, and 19 retrospective reviews. Eighty-one percent of articles (n = 22) recommended negative-pressure wound therapy in malignancy-resected wounds. Meta-analysis determined that the treatment yielded significantly lower overall surgical site infection (p = 0.004) and wound complication (p = 0.01) rates than standard surgical dressings; however, there were no statistically significant differences found for other outcomes between the two groups. Conclusions: This review demonstrates favorable outcomes of negative-pressure wound therapy over standard surgical dressings for malignancy-resected wounds without an increased risk of malignancy recurrence. However, because limited randomized controlled trials (detailing only incisional wounds for limited malignancies and anatomic regions) are available, additional high-power randomized controlled trials are recommended.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

“…18,21,22,27,32,34 Our review only contains four randomized controlled trials and is predominantly composed of retrospective chart reviews (n = 19, 70 percent), which are inherently prone to interpreter, incomplete data collection, and investigator bias. [17][18][19][20][23][24][25][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] Some articles reported…”

Section: Limitationsmentioning

confidence: 99%

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“Negative Pressure Wound Therapy (NPWT) Yields Lower Wound Complication and Surgical Site Infection Rates Compared to Standard Surgical Dressings (SSDs) after Resection of a Malignancy: A Systematic Review and Meta-Analysis”

Hays¹,

Singh²,

Saragossi³

et al. 2022

Plastic &Amp; Reconstructive Surgery

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Negative pressure wound therapy for surgical wounds healing by primary closure

Webster

Liu

Norman

et al. 2019

Cochrane Database of Systematic Reviews

132

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Negative pressure wound therapy for surgical wounds healing by primary closure

Norman

Goh

Dumville

et al. 2020

Cochrane Database of Systematic Reviews

109

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BackgroundIndications for the use of negative pressure wound therapy (NPWT) are broad and include prophylaxis for surgical site infections (SSIs). While existing evidence for the effectiveness of NPWT remains uncertain, new trials necessitated an updated review of the evidence for the effects of NPWT on postoperative wounds healing by primary closure. ObjectivesTo assess the effects of negative pressure wound therapy for preventing surgical site infection in wounds healing through primary closure. Search methodsWe searched the Cochrane Wounds Specialised Register, CENTRAL, Ovid MEDLINE (including In-Process & Other Non-Indexed Citations), Ovid Embase, and EBSCO CINAHL Plus in February 2018. We also searched clinical trials registries for ongoing and unpublished studies, and checked reference lists of relevant included studies as well as reviews, meta-analyses, and health technology reports to identify additional studies. There were no restrictions on language, publication date, or setting. Selection criteriaWe included trials if they allocated participants to treatment randomly and compared NPWT with any other type of wound dressing, or compared one type of NPWT with another type of NPWT. Data collection and analysisFour review authors independently assessed trials using predetermined inclusion criteria. We carried out data extraction, 'Risk of bias' assessment using the Cochrane 'Risk of bias' tool, and quality assessment according to GRADE methodology.

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Effect of Negative Pressure Wound Therapy on Wound Complications Following Pancreatectomy

Cited by 5 publications

References 0 publications

“Negative Pressure Wound Therapy (NPWT) Yields Lower Wound Complication and Surgical Site Infection Rates Compared to Standard Surgical Dressings (SSDs) after Resection of a Malignancy: A Systematic Review and Meta-Analysis”

“Negative Pressure Wound Therapy (NPWT) Yields Lower Wound Complication and Surgical Site Infection Rates Compared to Standard Surgical Dressings (SSDs) after Resection of a Malignancy: A Systematic Review and Meta-Analysis”

Negative pressure wound therapy for surgical wounds healing by primary closure

Negative pressure wound therapy for surgical wounds healing by primary closure

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