Effect of Neiyi Prescription of QIU on autophagy and angiogenic ability of endometriosis via the PPARγ/NF-κB signaling pathway

Yang, Huadi; Zhu, Qun-Fei; Li, Hui; Jiang, Xin; Xu, Xuqun; Guo, Yong

doi:10.1007/s00404-022-06537-w

Cited by 2 publications

(1 citation statement)

References 34 publications

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“…Yang et al established endometriosis rats with estradiol valerate and autologous transplantation and administered different doses of the Chinese traditional medicine QIU through oral gavage for 4 weeks, which promoted autophagy and inhibited angiogenesis by regulating the PPARγ/Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway ( 79 ).…”

Section: The Role Of Ppars In the Pathogenesis Of Endometriosismentioning

confidence: 99%

The role of peroxisome proliferator-activated receptors in endometriosis

Psilopatis,

Theocharis,

Beckmann

2024

Front. Med.

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Endometriosis constitutes the most common cause of chronic pelvic pain in female patients and is associated with infertility. Although there is no known cause for the disease, it is a heritable condition that is determined by numerous genetic, epigenetic, and environmental aspects. Peroxisome proliferator-activated receptors (PPARs) represent nuclear receptor proteins that control gene expression. By using the MEDLINE and LIVIVO databases we conducted a literature review in order to look into the role of PPARs in the endometriosis pathophysiology and succeeded in revealing 36 pertinent publications between 2001 and 2022. In regards to PPAR expression in endometriosis, PPARγ seems to represent the most studied PPAR isoform in endometriosis and to influence various pathways involved in the disease onset and progression. It's interesting to note that diverse treatment agents targeting the PPAR system have been identified as innovative, effective therapeutic alternatives in the context of endometriosis treatment. In conclusion, PPARs appear to contribute an important role in both endometriosis pathophysiology and therapy.

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Section: The Role Of Ppars In the Pathogenesis Of Endometriosismentioning

confidence: 99%