Effect of Nelumbo nucifera rhizome extract in haloperidol induced Parkinson rat model

Abstract

In the present investigation, we tried to evaluate the anti-Parkinson activity of NN rhizome in haloperidol-induced Parkinson in mice.Material and Method: Ethanolic extract was obtained from the rhizome of Nelumbo nucifera (NN). The solvent extractions were subjected to preliminary phytochemical screening. Neural degeneration was induced in a group (2, 3,4,5) by ip. Administration of Haloperidol at 1mg/kg in an animal. The standard drug L-Dopa 30 mg/kg ip. was ingested to group 3 animals before 30 of haloperidol challenge for 14 days. EENN at 250 and 500 mg/kg daily orally were given to G4, and G5 respectively before 30 min of haloperidol challenge for 14 days. A behavioral parameter was recorded on days 7 and 13 for bar test, days 8 and 14 for the rotarod test, and days 6 and 11 for locomotor activity. All statistical analyses were done with one-way and two-way ANOVA followed by Tukey's multiple comparison tests.Result: EENN significantly (p<0.0001) improves the experimental rat's muscle coordination, locomotor, and catatonic behavior. Conclusion: Nelumbo nucifera extract produces maximum (dose-dependent) significant action on Parkinson (dopaminergic neuron) in haloperidol-induced Parkinson in an animal.