Effect of neonatal capsaicin and infraorbital nerve section on whisker-related patterns in the rat trigeminal nucleus

Waite, Phil M.E.; Permentier, Patrick J. de

doi:10.1002/(sici)1096-9861(19970908)385:4<599::aid-cne6>3.0.co;2-z

Cited by 8 publications

(4 citation statements)

References 92 publications

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“…In this nucleus, as in Pr5 or Sp5ip, sets of primary afferents and clusters of neurons aggregate to form the vibrissa‐related patterns known as barrelettes (Arvidsson, ; Belford and Killackey, ; Chiaia et al, ). In Sp5c these clusters distribute in laminae III–IV and spare laminae I–II (Waite and De Permentier, ), as did most of our Sp5c–Pr5 neurons. Early electrophysiological studies showed that laminae III and IV neurons receive predominantly non‐nociceptive inputs of Aβ fibers (Willis and Coggeshall, ) and are activated by vibrissae and/or guard hair deflection, whereas cells that responded best to nociceptive stimulation were located primarily in laminae I, II, and deep V (Renehan et al, ).…”

Section: Discussionsupporting

confidence: 65%

Trigeminal intersubnuclear neurons: Morphometry and input‐dependent structural plasticity in adult rats

Martín

Negredo

Villacorta-Atienza

et al. 2014

J of Comparative Neurology

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Intersubnuclear neurons in the caudal division of the spinal trigeminal nucleus that project to the principal nucleus (Pr5) play an active role in shaping the receptive fields of other neurons, at different levels in the ascending sensory system that processes information originating from the vibrissae. By using retrograde labeling and digital reconstruction, we investigated the morphometry and topology of the dendritic trees of these neurons and the changes induced by long-term experience-dependent plasticity in adult male rats. Primary afferent input was either eliminated by transection of the right infraorbital nerve (IoN), or selectively altered by repeated whisker clipping on the right side. These neurons do not display asymmetries between sides in basic metric and topologic parameters (global number of trees, nodes, spines, or dendritic ends), although neurons on the left tend to have longer terminal segments. Ipsilaterally, both deafferentation (IoN transection) and deprivation (whisker trimming) reduced the density of spines, and the former also caused a global increase in total dendritic length and a relative increase in more complex arbors. Contralaterally, deafferentation reduced more complex dendritic trees, and caused a moderate decline in dendritic length and spatial reach, and a loss of spines in number and density. Deprivation caused a similar, but more profound, effect on spines. Our findings provide original quantitative descriptions of a scarcely known cell population, and show that denervation- or deprivation-derived plasticity is expressed not only by neurons at higher levels of the sensory pathways, but also by neurons in key subcortical circuits for sensory processing.

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Section: Discussionsupporting

confidence: 65%

Trigeminal intersubnuclear neurons: Morphometry and input‐dependent structural plasticity in adult rats

Martín

Negredo

Villacorta-Atienza

et al. 2014

J of Comparative Neurology

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“…The ION does innervate the nasal septum, but it primarily innervates cutaneous structures, such as the skin of the side of the nose and lower eyelid, and lower and upper lip (Shankland, 2001b ; Gray et al, 2016 ). Furthermore, the ION provides the major sensory innervation of the mystacial vibrissae of rodents (Vincent, 1913 ; Dykes, 1975 ; Jacquin et al, 1984 ; Rice et al, 1993 ; Waite and de Permentier, 1997 ; Maklad et al, 2004 ). Injection of WGA into the main trunk of the ION within the orbit labeled the superficial laminae of MDH in a fashion similar to WGA labeling of individual vibrissae (Arvidsson, 1982 ; Nomura et al, 1986 ; Arvidsson and Rice, 1991 ) or the palpebral conjunctiva (Panneton et al, 2010c ).…”

Section: Discussionmentioning

confidence: 99%

Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response

et al. 2018

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Most terrestrial animals demonstrate an autonomic reflex that facilitates survival during prolonged submersion under water. This diving response is characterized by bradycardia, apnea and selective increases in peripheral vascular resistance. Stimulation of the nose and nasal passages is thought to be primarily responsible for providing the sensory afferent signals initiating this protective reflex. Consequently, the primary objective of this research was to determine the central terminal projections of nerves innervating the external nose, nasal vestibule and nasal passages of rats. We injected wheat germ agglutinin (WGA) into specific external nasal locations, into the internal nasal passages of rats both with and without intact anterior ethmoidal nerves (AENs), and directly into trigeminal nerves innervating the nose and nasal region. The central terminations of these projections within the medulla were then precisely mapped. Results indicate that the internal nasal branch of the AEN and the nasopalatine nerve, but not the infraorbital nerve (ION), provide primary innervation of the internal nasal passages. The results also suggest afferent fibers from the internal nasal passages, but not external nasal region, project to the medullary dorsal horn (MDH) in an appropriate anatomical way to cause the activation of secondary neurons within the ventral MDH that express Fos protein during diving. We conclude that innervation of the anterior nasal passages by the AEN and nasopalatine nerve is likely to provide the afferent information responsible for the activation of secondary neurons within MDH during voluntary diving in rats.

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“…A systemic administration of capsaicin to neonatal animals caused attenuation of the nociceptive reflex against noxious chemical and thermal stimuli in their postnatal stage by an elimination of unmyelinated afferent fibers (6,10,13,16,37). However, animals with neonatal capsaicin treatment displayed a re-appearance of SP-immunoreaction in the dorsal horn during the postnatal period despite the continuous suppression of nocifensive responses (12).…”

Section: Animals and Neonatal Capsaicin Treatmentmentioning

confidence: 99%

The effect of neonatal capsaicin treatment on the CGRP-immunoreaction in the trigeminal subnucleus caudalis of mice

2008

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The calcitonin-gene related peptide (CGRP) is a primary afferent neurotransmitter in the trigeminal system. Although a neonatal administration of capsaicin eliminates substance P (SP)-mediated nociceptive responses to induce a permanent functional reduction in C-fibers, little information is available regarding changes in CGRP-immunoreaction in mice undergoing neonatal capsaicin treatment (CP mice). This study examined postnatal changes in the distribution of CGRP-immunoreaction in the trigeminal subnucleus caudalis and trigeminal ganglion of CP mice by immunohistochemical technique and a quantitative analysis. Immunohistochemistry for CGRP in the subnucleus caudalis (Vc) demonstrated two dense distributions of neurons in the CP mice as well as naïve mice: in the marginal layer and the region 400-600 μm deep. The quantitative analysis revealed no significant difference in the density of CGRP immunoreaction between naïve and CP mice 1-8 weeks of age. In the trigeminal ganglion of both groups, the size distribution of CGRPpositive neurons displayed a distribution pattern with one peak in 200-300 μm 2 at week 1 and with two peaks in 200-300 μm 2 and 600-700 μm 2 at week 8 but no significant difference in neural density existed between these regions. When double staining in the naïve mice with CGRP or SP and VR1, a capsaicin receptor, was done, many trigeminal ganglion neurons co-expressed SP-and VR1-immunoreactions, but rarely exhibited CGRP/VR1-co-localization. Taken together with previous data, these current observations suggest that CGRP containing afferent neurons possibly performs differing roles in nociceptive afferent input transmission within the Vc from SP-containing neurons in mice.Calcitonin gene-related peptide (CGRP), widely distributed in central and peripheral nervous systems, has diverse functions including that as a primary afferent neurotransmitter. This neuropeptide is involved in nociception, as strongly suggested by experimental findings that a cyclooxygenese inhibitor attenuated a release of CGRP from the trigeminal nucleus caudalis (17), and that a bath application of CGRP also produced a slow action potential in dorsal root ganglion cells (20). Indeed, an intravenous administration of CGRP induces headache in migraineurs (19). In addition to the nociceptive function, CGRP enhances excitations of wide dynamic range neurons caused by NMDA or AMPA receptor agonist, suggesting a nociceptive modulation role of CGRP (8). Substance P (SP) is also a slow acting neurotransmitter that serves as a modulator of nociceptive transmission (36). CGRP is released from Aδ-and C-fibers while SP is from C-fibers (3,22,23).

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Effect of neonatal capsaicin and infraorbital nerve section on whisker-related patterns in the rat trigeminal nucleus

Cited by 8 publications

References 92 publications

Trigeminal intersubnuclear neurons: Morphometry and input‐dependent structural plasticity in adult rats

Trigeminal intersubnuclear neurons: Morphometry and input‐dependent structural plasticity in adult rats

Innervation of the Nose and Nasal Region of the Rat: Implications for Initiating the Mammalian Diving Response

The effect of neonatal capsaicin treatment on the CGRP-immunoreaction in the trigeminal subnucleus caudalis of mice

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