Effect of neonatal modulation of cholesterol homeostasis on subsequent response to cholesterol challenge in adult guinea pig.

Li, J R; Bale, Laurie K.; Kottke, Bruce A.

doi:10.1172/jci109758

Cited by 35 publications

(16 citation statements)

References 30 publications

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“…The most convincing evidence of longstanding effects of nutrition in infancy on blood cholesterol concentration comes from animal studies performed in rats, rabbits, guineapigs or baboons (Coates et al, 1983;Hahn & Koldovski, 1976;Hulbron et al, 1982;Li et al, 1980;McGill et al, 1996;Reiser & Sildlerman, 1972;Whatley et al, 1981). The most comprehensive animal data come from different experiments in baboons (McGill et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

Infant-feeding patterns are related to blood cholesterol concentration in prepubertal children aged 5–11 y: The Fleurbaix-Laventie Ville Santé study

et al. 2000

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Objective: Several studies, mainly in animals, but also in humans, have shown that diet in infancy is associated with differences in blood cholesterol concentrations later in life. The objective was to examine this relationship in children aged 5 ± 11 y after taking into account their current diet and parental hypercholesterolemia. Setting and subjects: 251 prepubertal boys and 223 prepubertal girls enrolled in the schools in two little towns in northern France. Design and methods: Cross-sectional evaluation including measurements of cholesterol concentrations on capillary blood and a single weekday food intake record. Infant feeding patterns were obtained by questionnaire given to the mothers Results: 50% of the children had been breast-fed for a median duration of less than 2 months. Cow's milk was introduced in the diet as whole milk for 33% of the children. After adjustment for age, height, and sibship, capillary cholesterol concentration was lower in boys who had been breast fed (geometric mean: 4.4, 95% con®dence interval of the mean: 4.2 ± 4.6 mmolaL) than in those fed with formula (4.7, 4.5 ± 4.8 mmolaL, P`0.03). In girls, breastfeeding had no signi®cant effect on blood cholesterol concentration, which was associated with the type of cow's milk given in infancy: whole milk: 4.9 mmolaL (4.7 ± 5.2); totally or partially skimmed milk: 4.5 mmolaL (4.2 ± 4.6), P`0.008. The current saturated fat and cholesterol intakes and parental hypercyholesterolemia were associated with current blood cholesterol concentration in children, but did not modify its relationship with infant feeding patterns. Conclusion: Results of the present study suggest that diet in infancy may have longstanding effect on lipid metabolism.

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Section: Discussionmentioning

confidence: 99%

Infant-feeding patterns are related to blood cholesterol concentration in prepubertal children aged 5–11 y: The Fleurbaix-Laventie Ville Santé study

et al. 2000

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“…A new systematic review of the literature showed that breastfeeding is associated with increased mean TC and low density lipoprotein (LDL) levels in infancy but lower levels in adult life (Owen et al, 2002). This could partly be explained by the effect of early ingestion of a diet rich in cholesterol, leading to high plasma cholesterol, which in animal studies has been suggested to protect against high cholesterol challenges later in life (Reiser and Sidelman, 1972;Reiser et al, 1979;Li et al, 1980). However, the meaning of cholesterol concentration in early childhood for health in later life is still not clear, and we do not at present know what is the most favourable concentration of plasma lipids during infancy (Karlsland et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Birth weight, growth and feeding in infancy: relation to serum lipid concentration in 12-month-old infants

2003

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Objective: To assess the effects of birth size, growth and feeding in infancy on serum lipids in 12-month-old infants. Design: A longitudinal observation study on infants' consumption and growth. Food and growth records were made every month. At 6, 9 and 12 months, food records were weighed to calculate intake. Serum total cholesterol (TC), high-density lipoprotein-cholesterol (HDL), low-density lipoprotein (LDL) -cholesterol and triglyceride concentrations were analysed at 12 months. Settings: Birth and growth information was gathered from maternity wards and healthcare centres in Iceland and food consumption data at home. Subjects: Randomly selected newborns (n ¼ 180) according to the mother's domicile and 77% (n ¼ 138) participated, of them 75% (n ¼ 103), came in for blood sampling. Results: Among boys, a 1 kg higher birth weight resulted in a 0.79 mmol/l higher TC (P ¼ 0.005), but nonsignificant after adjustment for growth. Duration of breastfeeding was related to LDL-cholesterol (B ¼ 0.06 70.02, P ¼ 0.020, adj. R 2 ¼ 0.039), adjusting for gender. Independent of size at birth and breastfeeding, increase in length from 6 to 12 months and in weight from birth to 12 months were negatively related to TC (B ¼ À0.45570.156, P ¼ 0.008 and B ¼ À1.08670.474, P ¼ 0.032, respecitvely) in boys. PUFA was the strongest nutrient variable predicting TC (B ¼ 0.332, adj. R 2 ¼ 0.24, P40.001). Cod liver oil consumption increased both TC and LDL-cholesterol in girls (B ¼ 0.14170.051, P ¼ 0.008 and B ¼ 0.11270.047, P ¼ 0.021, respectively). Conclusion: Slower growth of high birth weight infants and breastfeeding contributes to higher TC concentration at the age of 12 months. Nutrient intake in infancy also affects lipid profile. The effect of birth weight, growth and nutrient intake in infancy on lipid profile is different for boys and girls.

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“…31,32 This suggests that long-term cholesterol homeostasis could be affected by the level of dietary cholesterol in the infant diet. However, these effects were not seen in guinea pigs 10 and, among human fetuses, increases in hepatic LDL receptor activity were associated positively with gestational age and were correlated inversely with serum total cholesterol and LDL cholesterol levels. 40 The current study confirms feedback inhibition of cholesterol synthesis among human infants, dependent on exposure to dietary cholesterol.…”

Section: Discussionmentioning

confidence: 80%

“…Early exposure to dietary cholesterol appeared to "protect" against diet-induced hypercholesterolemia in adulthood, because adult male offspring exhibited an inverse relationship between serum cholesterol concentrations and the cholesterol content of their mothers' milk. Results from studies in a variety of species produced conflicting results; other rat studies supported 5 or refuted 6 the hypothesis, studies in pigs supported the hypothesis, 7 and studies in baboons 8,9 and guinea pigs 10 did not support the hypothesis.…”

mentioning

confidence: 97%

Effects of Early Cholesterol Intake on Cholesterol Biosynthesis and Plasma Lipids Among Infants Until 18 Months of Age

et al. 2005

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Background. The endogenous cholesterol fractional synthesis rate (FSR) is related inversely to infant dietary cholesterol at 4 months of age; however, it remains to be established whether this effect is permanent, possibly contributing to later hypercholesterolemia. Objective. To determine whether levels of dietary cholesterol in infancy induced changes in FSR and plasma lipid levels that persisted at 18 months. Methods. A prospective clinical trial was conducted with 47 infants, from their first week of life until 18 months of age, who received human milk (HM) until weaned (n = 15) or were randomized to receive modified cow's milk formula (MCF) with added cholesterol (n = 15) or cow's milk formula (CF) (n = 17) for 12 months. Cholesterol contents of HM, MCF, and CF were 120, 80, and 40 mg/L, respectively. FSR and plasma lipid levels were measured at 4 and 18 months. Results. At 4 months, total cholesterol and low-density lipoprotein cholesterol levels were higher for infants fed HM and MCF, compared with CF. High-density lipoprotein cholesterol levels were higher in the MCF group than in the HM and CF groups. FSR in the HM group (0.034 ± 0.005 pools per day) was lower than that in the CF group (0.052 ± 0.005 pools per day). There was no difference between the HM and MCF (0.047 ± 0.005 pools per day) groups or between the MCF and CF groups. At 18 months, there were no differences in FSRs or plasma lipid profiles between the groups. Conclusion. Although cholesterol intake before weaning affects FSRs and plasma lipid profiles at 4 months, these differences do not persist after weaning to an unrestricted diet at 18 months. This provides additional evidence that there is no imprinting of FSR in infancy with differing dietary levels of cholesterol.

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Effect of neonatal modulation of cholesterol homeostasis on subsequent response to cholesterol challenge in adult guinea pig.

Cited by 35 publications

References 30 publications

Infant-feeding patterns are related to blood cholesterol concentration in prepubertal children aged 5–11 y: The Fleurbaix-Laventie Ville Santé study

Infant-feeding patterns are related to blood cholesterol concentration in prepubertal children aged 5–11 y: The Fleurbaix-Laventie Ville Santé study

Birth weight, growth and feeding in infancy: relation to serum lipid concentration in 12-month-old infants

Effects of Early Cholesterol Intake on Cholesterol Biosynthesis and Plasma Lipids Among Infants Until 18 Months of Age

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