Effect of neonatal monosodium glutamate on lipid peroxidation in adult rat brain

Summary Neonatal exposure to monosodium glutamate (MSG) induces circadian disorders in several physiological and behavioural processes regulated by the suprachiasmatic nucleus (SCN). The objective of this study was to evaluate the effects of neonatal exposure to MSG on locomotor activity, and on morphology, cellular density and expression of proteins, as evaluated by optical density (OD), of vasopressin (VP)‐, vasoactive intestinal polypeptide (VIP)‐ and glial fibrillary acidic protein (GFAP)‐immunoreactive cells in the SCN. Male Wistar rats were used: the MSG group was subcutaneously treated from 3 to 10 days of age with 3.5 mg/g/day. Locomotor activity was evaluated at 90 days of age using ‘open‐field’ test, and the brains were processed for immunohistochemical studies. MSG exposure induced a significant decrease in locomotor activity. VP‐ and VIP‐immunoreactive neuronal densities showed a significant decrease, while the somatic OD showed an increase. Major axes and somatic area were significantly increased in VIP neurons. The cellular and optical densities of GFAP‐immunoreactive sections of SCN were significantly increased. These results demonstrated that newborn exposure to MSG induced morphological alterations in SCN cells, an alteration that could be the basis for behavioural disorders observed in the animals.

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“…It is probably induced by prolonged overexcitation of glutamate receptors (Bawari et al . ; Swamy et al . ).…”

Section: Discussionmentioning

confidence: 95%

Neonatal exposure to monosodium glutamate induces morphological alterations in suprachiasmatic nucleus of adult rat

Rojas-Castañeda

Vigueras-Villaseñor

Chávez-Saldaña

et al. 2016

Int J Experimental Path

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“…Although several mechanisms have been proposed, the pathophysiology of sporadic ALS remains unclear (Babu et al 1994(Babu et al , 1998(Babu et al , 2008aBawari et al 1995Bawari et al , 1993Cleveland and Rothstein 2001;Heath and Shaw 2002;Robertson et al 2002;Rowland and Shneider 2001). Among the environmental factors implicated in the pathogenesis of ALS, exposure to heavy metals, especially Hg, received considerable attention.…”

Section: Discussionmentioning

confidence: 99%

Mercury exposure in sporadic amyotrophic lateral sclerosis patients from Ganga plain region in India: A retrospective study

Kumar

Bhardwaj

Tiwari

et al. 2010

Toxicological & Environmental Chemistry

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Amyotrophic lateral sclerosis (ALS), a progressive disorder that usually runs a fatal course within 2-5 years of onset, is characterized by loss of motor neurons in the cortex, brain stem, and spinal cord. In this study mercury (Hg) concentrations were determined in blood samples of 40 ALS patients, of whom 24 ALS patients were from the Ganga plain region and their metal levels were found to be significantly higher. In contrast, Hg levels in the 16 ALS patients from non-Ganga plain regions whose levels were similar to those of the control subjects. Mercury in stream water samples and freshly deposited stream sediment were determined in the locations of patients' native residences along the Ganga plain region and metal levels were found to be higher than the threshold guideline values for Hg in stream waters recommended by WHO. The geo-accumulation index in selected sites of freshly deposited stream sediment ranged from moderate to highly polluted. The high levels of Hg observed in ALS patients may potentially alter the redox status of neuronal cell components and induce celldeath pathways.

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“…Monosodium glutamate (4mg/g body weight)-treatment decreased the antioxidant capacity of midbrain region and increased lipid peroxidation [71], via increasing thiobarbituric acid reactive substances and delay the acrophases of GSH and catalase as a result of increased glutamate levels [72].…”

Section: Monosodium Glutamate Related Neurotoxicitymentioning

confidence: 99%

Promising role of Carob (Ceratonia siliqua L) phytochemical components against neurotoxicity induced by monosodium glutamate

El‐Sayyad¹,

El-Kholy²,

Hamed³

2017

Glob J Zool

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DOICC By 024Citation: IH El-Sayyad H, Elkholy WME, Hamed WAE (2017) Promising role of Carob (Ceratonia siliqua L) phytochemical components against neurotoxicity induced by monosodium glutamate. Glob J Zool 2(1): 024-032. Life Sciences Group AbstractThe phytochemical constituents of Carob (Ceratonia siliqua L) showed therapeutic medical importance especially concerning neurotoxicity which represents the major public health problem. Neurodegenerative disorders are developed from different metabolic diseases and chemical component such as monosodium glutamate. It is the widely used chense sodium salt of the non-essential glutamic amino acid. It is one of the most popular fl avor enhancer. Monosodium glutamate is excitatory neurotransmitter in brain, increased the perception of wetness and saltiness as a taste sensation UMAMI. Treatment with the carob extract or their phytochemical constituents either protect or ameliorates these diseases which is promising.

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Effect of neonatal monosodium glutamate on lipid peroxidation in adult rat brain

Cited by 15 publications

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Neonatal exposure to monosodium glutamate induces morphological alterations in suprachiasmatic nucleus of adult rat

Neonatal exposure to monosodium glutamate induces morphological alterations in suprachiasmatic nucleus of adult rat

Mercury exposure in sporadic amyotrophic lateral sclerosis patients from Ganga plain region in India: A retrospective study

Promising role of Carob (Ceratonia siliqua L) phytochemical components against neurotoxicity induced by monosodium glutamate

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