EFFECT OF NEONATAL OESTROGEN AND hCG TREATMENT ON THE GENITAL ORGANS OF ADULT FEMALE RATS

Abstract

The ovaries and the uterine as well as vaginal mucous membranes of 80-, 180-and 365-day-old intact female rats and females neonatally treated with a single dose of oestrogen and repeated doses of human chorionic gonadotropin (D+/ were studied. Numerous follicles, interstitial cells and corpora lutea (CL) were Key words: Rat, ovary, uterus, vagina, oestrogen, hCG The progressive decline of regular oestrous cycles and ovulatory functions with advancing age in female rats has been well documented in previous studies (Pantic and Lovren, 1981;Ennis and Davies, 1982;Nass et al., 1984). In female rats and mice, neonatal oestrogen treatment induces changes in the reproductive tract that may persist throughout the animals life (Pantic, 1981). These changes include a persistent rather than cyclic oestrus. During persistent oestrus, circulating oestradiol is present from many large ovarian follicles, but the luteinizing hormone surge mechanism is inhibited and ovulation does not occur (Leung, 1978;Pantic and Lovren, 1981).Studies on abnormalities of the reproductive tract indicate that oestrogens have inhibitory effects on ovarian steroidogenesis (Groen-Clevant, 1981;Wada et al., 1984). The uterus and vagina are also dependent on the effect of hormones administered to neonates (Ennis and Davies, 1982;Keys and King, 1989).In this paper, attention is focused on the ovarian follicles and interstitial tissue and on the properties of uterus and vagina in adult rats neonatally treated with oestrogen and human chorionic gonadotropin (hCG).

Stereological and Histopathological Effects of Trigonella foenum-graecum Seeds on Rabbits Ovary

“…Jhon et al (16) showed that plant extract may have an effect on the production and secretion of FSH which secret from the pituitary gland and these changes in the secretion of the FSH and LH may occurred as a result from the effect of caffaic acids and cause a reduction in reproduction. On the other hand (17) revealed that the exogenous sources of estrogen may lead to decrease the number of different types of follicles, cause of cystic follicle and decrease in the number of the corpus luteum in female rat. Other study revealed that 3% of T. foenum-graecum seeds increased the concentration of estrogen and the concentration of progesterone has significantly decreased at 1.5% of T. foenum-graecum (7).…”