Effect of Neonatal Treatment with Monosodium Glutamate on the Secretion of α-MSH, β-Endorphin and ACTH in the Rat

Conte-Devolx, B; Giraud, Pierre; Castanas, Elias; Boudouresque, F; Orlando, Mariateresa; Gillioz, P.; Oliver, Charles

doi:10.1159/000123230

Cited by 33 publications

(18 citation statements)

References 13 publications

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“…However, the corticosterone concentration measured in later time intervals following stress stimuli was higher in rats treated neonatally with MSG compared to controls. Consistently, in both groups of animals, a similar magnitude of ACTH and corticosterone responses to restraint and ether exposure is apparent in other reports [6, 11, 13]. On the other hand, both reduced [12] and increased hormone responses [10, 11, 13] were reported in rats treated with MSG.…”

Section: Discussionsupporting

confidence: 89%

“…The maintenance of normal plasma ACTH concentration in MSG-treated rats observed in this study could be at least partly related to normal ACTH stores in the pituitary gland. Some authors, however, failed to observe changes in pituitary ACTH concentration after MSG treatment [5, 6]. Thus elevated POMC gene expression might have developed to compensate the atrophy of the pituitary in MSG-treated rats, leading to the preservation of the normal function of the pituitary with regard to the HPA axis.…”

Section: Discussionmentioning

confidence: 99%

“…However, the results obtained in adult rats neonatally treated with MSG are in many cases contradictory and they are inconsistent also with regard to the changes of individual parameters of the HPA axis. Thus, some authors reported normal plasma and pituitary adrenocorticotropin (ACTH) concentrations and normal plasma corticosterone levels under both resting and stress conditions [5, 6, 7, 8], while others found increased basal and stress-induced corticosterone secretion with or without concomitant increase in ACTH release [9, 10, 11, 12]. The issue has become even more complicated by the data of a recent study [13] reporting decreased levels of plasma ACTH and of corticotropin-releasing hormone (CRH) mRNA levels in the paraventricular nucleus (PVN) in neonatally MSG-treated rats.…”

Section: Introductionmentioning

confidence: 99%

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Neurotoxic Lesions Induced by Monosodium Glutamate Result in Increased Adenopituitary Proopiomelanocortin Gene Expression and Decreased Corticosterone Clearance in Rats

Škultétyová

Kiss²,

Ježová³

1998

Neuroendocrinology

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Hypothalamic-pituitary-adrenocortical function in rats with brain lesions induced by neonatal monosodium glutamate (MSG) treatment (4 mg/g, 5 administrations, i.p.) was evaluated in the present study. Using in situ hybridization we found increased proopiomelanocortin (POMC) mRNA levels in the adenopituitary and normal corticotropin-releasing hormone mRNA levels in the hypothalamic paraventricular nucleus in MSG-treated rats. The total content of pituitary adrenocorticotropin (ACTH) was not changed, while pituitary ACTH concentration was higher in MSG-treated compared to control rats. The number of ACTH-immunostained cells per a constant area of adenohypophysial section, as measured by immunohistochemistry, was unchanged indicating that no significant condensation of corticotropes occurred. Basal plasma ACTH concentrations were not different, whereas morning corticosterone levels were elevated in rats with MSG treatment. While ACTH response to stress stimuli was similar in both groups of rats, corticosterone response to exogenous ACTH (500 ng/kg, i.v., Synacthen), short-lasting handling and immobilization was of the same magnitude but prolonged in MSG-treated rats. Based on the decline of [³H]corticosterone in plasma, a decreased corticosterone clearance rate was found in MSG-treated rats. These findings suggest that MSG treatment results in increased POMC gene expression per corticotrope of the atrophic pituitary resulting in maintenance of normal pituitary ACTH stores and plasma ACTH levels. Elevated basal levels of corticosterone in plasma as well as prolonged corticosterone responses to stimulations in rats treated with MSG seem to be due to a decreased clearance rate of corticosterone.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Neurotoxic Lesions Induced by Monosodium Glutamate Result in Increased Adenopituitary Proopiomelanocortin Gene Expression and Decreased Corticosterone Clearance in Rats

Škultétyová

Kiss²,

Ježová³

1998

Neuroendocrinology

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“…0.04) 6-hour increase in ACTH in the 20-minrotation group than in the 10-min-rotation group. Other studies have demonstrated that ACTH and ß-endorphin release can be dissociated [26,27]. Conte-Devolx et al [26] demonstrated that chemical lesion of the arcuate nucleus results in dissociation of ACTH and ß-endorphin release.…”

Section: Discussionmentioning

confidence: 99%

“…Other studies have demonstrated that ACTH and ß-endorphin release can be dissociated [26,27]. Conte-Devolx et al [26] demonstrated that chemical lesion of the arcuate nucleus results in dissociation of ACTH and ß-endorphin release. Another instance of dissociation is found in the influence of sex on plasma and pituitary ACTH and ß-endorphin concentration; plasma ACTH levels are higher in female than male rats while ß-endorphin levels are the same [27].…”

Section: Discussionmentioning

confidence: 99%

Effects of Rotational Stress of Different Duration on NK Cell Activity, Proinflammatory Cytokines, and POMC-Derived Peptides in Mice

Hale¹,

Ghanta

Gauthier

et al. 2001

Neuroimmunomodulation

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Previous studies have shown that the same stressor, depending on intensity, controllability, or duration, can have different effects on the immune system. The purpose of this study was to determine the effect of 10- and 20-min rotation on natural killer (NK) cell activity and also to establish if changes in body temperature, proinflammatory cytokine (IL-1β, IL-6, and TNF-α) levels, and proopiomelanocortin (POMC)-derived peptide (ACTH and β-endorphin) levels parallel the changes in NK cell activity in mice. We found that 10-min rotation significantly increased NK cell activity as compared to both the control (home cage) group and the 20-min-rotation group, while NK cell activity in the 20-min group was not significantly changed compared to the control group. Both 10 and 20 min of rotational stress decreased body temperature and induced significant changes in the proinflammatory cytokine and POMC-derived peptide levels as compared to the control group. The pattern of proinflammatory cytokine expression was quite different between the 10- and 20-min rotation groups. All three proinflammatory cytokines were expressed sequentially (at 0 h after rotation TNF-α, at 6 h IL-1β and IL-6, and at 24 h IL-6) in the 10-min rotation group, while the 20-min rotation group had a small increase in IL-1β (6.7 ± 1.8 pg/ml) at 0 h and increased levels of IL-6 at 6 and 24 h. There was a dissociation of ACTH and β-endorphin expression in both groups resulting in significantly more β-endorphin (p < 0.05) in the 10-min group at 6 h and significantly more ACTH (p < 0.04) in the 20-min group at 6 h. IL-1β and β-endorphin have both been shown to have a direct stimulatory effect on NK cell activity. Therefore, we suspect that the significant increase in both IL-1β and β-endorphin at 6 h in the 10-min-rotation group may be involved in the increased NK cell activity observed at 24 h in the 10-min-rotation group.

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Clinical and Neuroendocrinological Effects of Estrogens in Postmenopausal Women with Parkinson’s Disease

Bonuccelli

Piccini

Napolitano

et al. 1991

Advances in Behavioral Biology

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Effect of Neonatal Treatment with Monosodium Glutamate on the Secretion of α-MSH, β-Endorphin and ACTH in the Rat

Cited by 33 publications

References 13 publications

Neurotoxic Lesions Induced by Monosodium Glutamate Result in Increased Adenopituitary Proopiomelanocortin Gene Expression and Decreased Corticosterone Clearance in Rats

Neurotoxic Lesions Induced by Monosodium Glutamate Result in Increased Adenopituitary Proopiomelanocortin Gene Expression and Decreased Corticosterone Clearance in Rats

Effects of Rotational Stress of Different Duration on NK Cell Activity, Proinflammatory Cytokines, and POMC-Derived Peptides in Mice

Clinical and Neuroendocrinological Effects of Estrogens in Postmenopausal Women with Parkinson’s Disease

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