Effect of Nerve Growth Factor on Osseointegration of Titanium Implants in Type 2 Diabetic Rats

Zhang, Jing; Shirai, Mai; Yamamoto, Ryûji; Yamakoshi, Yasuo; Oida, Shinichiro; Ohkubo, Chikahiro; Zeng, Jianyu

doi:10.11607/jomi.4455

Cited by 13 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A reduction in the osteoblast surface ratio is accompanied by a disproportionate increase in OC-covered surface areas. Concurrently, GK rats exhibit impaired osseointegration indicated by lower BIC (Zhang et al 2016), decreasing serum OCN, and increased levels of TRAP and CTX-1 in the serum (Lee et al 2021). Indeed, implanted biomaterials exhibit diminished material properties in GK rats with appreciably lower maximum, yield, and stress loads (Liang et al 2019).…”

Section: Animal Models Of T2dmmentioning

confidence: 99%

Strategies for Improving Impaired Osseointegration in Compromised Animal Models

Deng,

Van Duyn,

Cohen

et al. 2024

J Dent Res

View full text Add to dashboard Cite

Implant osseointegration is reduced in patients with systemic conditions that compromise bone quality, such as osteoporosis, disuse syndrome, and type 2 diabetes. Studies using rodent models designed to mimic these compromised conditions demonstrated reduced bone-to-implant contact (BIC) or a decline in bone mineral density. These adverse effects are a consequence of disrupted intercellular communication. A variety of approaches have been developed to compensate for the altered microenvironment inherent in compromised conditions, including the use of biologics and implant surface modification. Chemical and physical modification of surface properties at the microscale, mesoscale, and nanoscale levels to closely resemble the surface topography of osteoclast resorption pits found in bone has proven to be a highly effective strategy for improving implant osseointegration. The addition of hydrophilicity to the surface further enhances osteoblast response at the bone-implant interface. These surface modifications, applied either alone or in combination, improve osseointegration by increasing proliferation and osteoblastic differentiation of osteoprogenitor cells and enhancing angiogenesis while modulating osteoclast activity to achieve net new bone formation, although the specific effects vary with surface treatment. In addition to direct effects on surface-attached cells, the communication between bone marrow stromal cells and immunomodulatory cells is sensitive to these surface properties. This article reports on the advances in titanium surface modifications, alone and in combination with novel therapeutics in animal models of human disease affecting bone quality. It offers clinically translatable perspectives for clinicians to consider when using different surface modification strategies to improve long-term implant performance in compromised patients. This review supports the use of surface modifications, bioactive coatings, and localized therapeutics as pragmatic approaches to improve BIC and enhance osteogenic activity from both structural and molecular standpoints.

show abstract

Section: Animal Models Of T2dmmentioning

confidence: 99%

Strategies for Improving Impaired Osseointegration in Compromised Animal Models

Deng,

Van Duyn,

Cohen

et al. 2024

J Dent Res

View full text Add to dashboard Cite

show abstract

“…Diabetes mellitus is another important risk factor for implant failure during the healing period [42][43][44]. Many studies confirmed that the BIC rate of implants in Goto-Kakizaki (GK) rats with type 2 diabetes mellitus was significantly lower than that in normal Wistar rats, and hyperglycemia played a key role in causing the bone remodeling disorders around the implants [45][46][47]. In addition, cellular studies showed that a high-glucose microenvironment could significantly inhibit the proliferation and osteogenic differentiation capacity of BMSCs, reduce the expression of osteogenesis-related genes, and decelerate in vitro mineralization [48][49][50].…”

Section: Effect Of Lipus On Implant Osseointegration In Thementioning

confidence: 99%

Effectiveness and Mechanisms of Low-Intensity Pulsed Ultrasound on Osseointegration of Dental Implants and Biological Functions of Bone Marrow Mesenchymal Stem Cells

Liang

Liu

Yan

et al. 2022

Stem Cells International

View full text Add to dashboard Cite

Dental implant restoration is the preferred choice for patients with dentition defects or edentulous patients, and obtaining stable osseointegration is the determining factor for successful implant healing. The risk of implant failure during the healing stage is still an urgent problem in clinical practice due to differences in bone quality at different implant sites and the impact of some systemic diseases on bone tissue metabolism. Low-intensity pulsed ultrasound (LIPUS) is a noninvasive physical intervention method widely recognized in the treatment of bone fracture and joint damage repair. Moreover, many studies indicated that LIPUS could effectively promote the osseointegration of dental implants and improve the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). This review is aimed at investigating the research progress on the use of LIPUS in dental implant medicine from three aspects: (1) discuss the promoting effects of LIPUS on osseointegration and peri-implant bone regeneration, (2) summarize the effects and associated mechanisms of LIPUS on the biological functions of BMSCs, and (3) introduce the application and prospects of LIPUS in the clinical work of dental implantation. Although many challenges need to be overcome in the future, LIPUS is bound to be an efficient and convenient therapeutic method to improve the dental implantation success rate and expand clinical implant indications.

show abstract

“…For multi-implant protocols, a diameter of 1.5 mm and length of 2.5 mm are more appropriate [ 343 , 347 ]. Research using the rat tibia model has commonly investigated the effects of the implant surface on osseointegration [ 343 , 344 ], but a new trend has emerged, with growing numbers of studies in the areas of the drug delivery and/or physiopathology: effects on osseointegration of different doses of drugs in rats that are healthy [ 345 ] or have certain diseases, e.g., diabetes [ 348 , 349 , 350 , 351 , 352 , 353 , 354 ], or in peri-implant bone defects [ 346 ]. Nevertheless, the framework of choice is implantation osseointegration in poor quality bone with drug treatments [ 355 , 356 ].…”

Section: Appendix A1 Research In Non-human Primatesmentioning

confidence: 99%

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

et al. 2021

View full text Add to dashboard Cite

Biomedical research seeks to generate experimental results for translation to clinical settings. In order to improve the transition from bench to bedside, researchers must draw justifiable conclusions based on data from an appropriate model. Animal testing, as a prerequisite to human clinical exposure, is performed in a range of species, from laboratory mice to larger animals (such as dogs or non-human primates). Minipigs appear to be the animal of choice for studying bone surgery around intraoral dental implants. Dog models, well-known in the field of dental implant research, tend now to be used for studies conducted under compromised oral conditions (biofilm). Regarding small animal models, research studies mostly use rodents, with interest in rabbit models declining. Mouse models remain a reference for genetic studies. On the other hand, over the last decade, scientific advances and government guidelines have led to the replacement, reduction, and refinement of the use of all animal models in dental implant research. In new development strategies, some in vivo experiments are being progressively replaced by in vitro or biomaterial approaches. In this review, we summarize the key information on the animal models currently available for dental implant research and highlight (i) the pros and cons of each type, (ii) new levels of decisional procedures regarding study objectives, and (iii) the outlook for animal research, discussing possible non-animal options.

show abstract

Effect of Nerve Growth Factor on Osseointegration of Titanium Implants in Type 2 Diabetic Rats

Cited by 13 publications

References 0 publications

Strategies for Improving Impaired Osseointegration in Compromised Animal Models

Strategies for Improving Impaired Osseointegration in Compromised Animal Models

Effectiveness and Mechanisms of Low-Intensity Pulsed Ultrasound on Osseointegration of Dental Implants and Biological Functions of Bone Marrow Mesenchymal Stem Cells

Pre-Clinical Models in Implant Dentistry: Past, Present, Future

Contact Info

Product

Resources

About