Effect of nerve stimulation on prostaglandin formation and release from the rat stomach

Coceani, Flavio; Pace-Asciak, Cecil R.; Volta, Francesco; Ls, Wolfe

doi:10.1152/ajplegacy.1967.213.4.1056

Cited by 191 publications

(53 citation statements)

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“…This evidence, together with reports that prostaglandin-like substances may be released upon sympathetic (Sammuelsson & Wennmalm, 1971) and also upon parasympathetic nerve stimulation (Coceani, Pace-Asciak, Volta & Wolfe, 1967;Junstad & Wennmalm, 1974), indicates a possible involvement of prostaglandins in the transmission process.…”

Section: Introductionsupporting

confidence: 65%

THE EFFECTS OF PROSTAGLANDINS E₁, E₂ AND F_2αON VAGAL BRADYCARDIA IN THE ANAESTHETIZED MOUSE

Feniuk

Large

1975

British J Pharmacology

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In anaesthetized mice prostaglandins E1 and E2 reduced the bradycardia caused by electrical stimulation of the sectioned peripheral vagus nerve; prostaglandin F2α produced only a slight inhibition of the vagal response. None of the prostaglandins studied affected acetylcholine‐induced bradycardia. Prostaglandins modify para sympathetic nerve activity in vivo presumably by a pre‐synaptic action.

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Section: Introductionsupporting

confidence: 65%

THE EFFECTS OF PROSTAGLANDINS E₁, E₂ AND F_2αON VAGAL BRADYCARDIA IN THE ANAESTHETIZED MOUSE

Feniuk

Large

1975

British J Pharmacology

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“…Others include heart (Wennmalm & Stjarme, 1971;Samuelsson & Wennmalm, 1971), kidney (Dunham & Zimmerman, 1970;Davis & Horton, 1972;McGiff, Crowshaw, Terragno, Malik & Lonigro, 1972), adipose tissue (Shaw & Ramwell, 1968), stomach (Bennett, Friedmann & Vane, 1967;Coceani, Pace-Asciak, Volta & Wolfe, 1967), and vas deferens (Hedqvist & von Euler, 1972). Since exogenous prostaglandins modify the responses of various organs to adrenergic nerve stimulation (see review by Brody & Kadowitz, 1974), it is possible that endogenous prostaglandins play a physiological role in the responses of such organs to autonomic control.…”

Section: Introductionmentioning

confidence: 99%

Prostaglandin Release From Cat and Dog Spleen

Bedwani

Millar

1975

British J Pharmacology

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The output of prostaglandins from the spleens of cats and dogs was studied. Comparison is made between the results found in the two species. The release of prostaglandins was investigated in isolated saline‐perfused spleens and in incubates of spleen slices. Release in response to nerve stimulation, and exposure to adrenaline or noradrenaline was compared with resting release. A resting release of prostaglandins was found in the dog but not in the cat spleen. Whereas stimulated dog spleens released microgram quantities of prostaglandins E2 and F2α, prostaglandin output from the cat spleen under similar conditions was undetectable or barely detectable. The identity of the prostaglandins released from the dog spleen (prostaglandins E2 and F2α) was confirmed by mass spectrometry. The species difference in prostaglandin output from the spleen is discussed in relation to the hypothesis that endogenous prostaglandins modify the responses of this organ to nervous stimuli.

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“…T%Y still stimulates the adenyl-cychise. After incubation of the thyroid slices in the presence of [ *%I jacetate, the prostagkdins are extracted [22] and analyzed by thin-layer chromatography We then turned our attentiorr to the titration of the endogenous phospholipase A activity in &e thyroid, in the presence or absence of TSH and in the presence of indomethacin in order to block the further conversion of arachidonic acid into prostaglandins. A corn--parative study was performed with two radioactive substrates: tl%l phosphatidyGcholine and [ t4C] phosphatidyl-inositol.…”

mentioning

confidence: 99%

Control by TSH of a phospholipase A₂ activity, a limiting factor in the biosynthesis of prostaglandins in the thyroid

Haye¹,

Champion²

1973

FEBS Letters

107

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Effect of nerve stimulation on prostaglandin formation and release from the rat stomach

Cited by 191 publications

References 0 publications

THE EFFECTS OF PROSTAGLANDINS E₁, E₂ AND F_2αON VAGAL BRADYCARDIA IN THE ANAESTHETIZED MOUSE

THE EFFECTS OF PROSTAGLANDINS E₁, E₂ AND F_2αON VAGAL BRADYCARDIA IN THE ANAESTHETIZED MOUSE

Prostaglandin Release From Cat and Dog Spleen

Control by TSH of a phospholipase A₂ activity, a limiting factor in the biosynthesis of prostaglandins in the thyroid

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Effect of nerve stimulation on prostaglandin formation and release from the rat stomach

Cited by 191 publications

References 0 publications

THE EFFECTS OF PROSTAGLANDINS E1, E2 AND F2αON VAGAL BRADYCARDIA IN THE ANAESTHETIZED MOUSE

THE EFFECTS OF PROSTAGLANDINS E1, E2 AND F2αON VAGAL BRADYCARDIA IN THE ANAESTHETIZED MOUSE

Prostaglandin Release From Cat and Dog Spleen

Control by TSH of a phospholipase A2 activity, a limiting factor in the biosynthesis of prostaglandins in the thyroid

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THE EFFECTS OF PROSTAGLANDINS E₁, E₂ AND F_2αON VAGAL BRADYCARDIA IN THE ANAESTHETIZED MOUSE

THE EFFECTS OF PROSTAGLANDINS E₁, E₂ AND F_2αON VAGAL BRADYCARDIA IN THE ANAESTHETIZED MOUSE

Control by TSH of a phospholipase A₂ activity, a limiting factor in the biosynthesis of prostaglandins in the thyroid