Effect of nettle seed on immune response in a murine model of allergic asthma

Irani, Mahboubeh; Choopani, Rasool; Esmaeili, Saeideh; Dargahi, Tahereh; Athari, Seyyede Masoume; Athari, Seyyed Shamsadin

doi:10.1016/j.reval.2020.03.007

Cited by 4 publications

(3 citation statements)

References 23 publications

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“…However, the exact extent to which UD affects eosinophil recruitment remains controversial, as other studies investigating biochemical parameters following UD treatment did not show evident or significant variations in eosinophil concentration (Criado et al 2006). Conversely, administration of nettle seeds extract in asthmatic mice models has been proven to significantly decrease eosinophil count (Irani et al 2020). According to these findings, further investigation ought to be carried out to establish the downregulatory action of UD on eosinophil count.…”

Section: Asthmamentioning

confidence: 97%

Comprehensive review of Urtica dioica L. (Urticaceae) phytochemistry and anti-inflammatory properties

Parente,

Paiva-Santos,

Cabral

et al. 2024

Phytochem Rev

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Herbal medicinal products are widely considered beneficial and gaining importance in preventing and treating several diseases. Urtica dioica L. (UD) is a medicinal plant that has been used as an herbal remedy and dietary supplement for centuries based on traditional experience or random trials without the know-how of phytoconstituents. UD is one of those herbs with a long record of anti-inflammatory activity and several mechanisms of action have been discussed. Plant part, extraction solvent, and phytoconstituents have a determinant effect on both efficacy and therapeutic objective. Current literature mainly elaborates on the antioxidant effect of Urtica species, with the anti-inflammatory role of UD still being a matter of discussion, as in vitro and in vivo studies have only been characterized to such an extent. In order to elaborate on this topic, the present review aims to characterize the anti-inflammatory action of several UD extracts according to in vitro and in vivo results, as well as the possible molecules and respective mechanism responsible for its anti-inflammatory effect on several pathologies. Despite the knowledge gathered so far surrounding the anti-inflammatory activity of UD, further studies are required to characterize the mechanism of action and discriminate between the molecules underlying the beneficial effects of nettle on inflammatory diseases.

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Section: Asthmamentioning

confidence: 97%

Comprehensive review of Urtica dioica L. (Urticaceae) phytochemistry and anti-inflammatory properties

Parente,

Paiva-Santos,

Cabral

et al. 2024

Phytochem Rev

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“…Then, drug treatment groups received AFSE theophylline for eight consecutive days (days 23-30). On day 31 of study, all mice were killed and then separated into two groups; one group of four animals for lung histopathology analysis and the other group of three mice for Bronchoalveolar lavage fluid (BALF) sampling [20].…”

Section: Asthma Induction and Drug Treatmentsmentioning

confidence: 99%

“…June 2021, Vol. 20, inflammatory responses of allergic asthma induced by OVA. More interestingly, AFSE alleviating effects on allergic asthma-stimulated inflammation were non-significantly higher than theophylline.…”

Section: Journal Of Medicinal Plants 34mentioning

confidence: 99%

Regulation effects of Trigonella foenum-graecum seed extract on a mouse model of allergic asthma

et al. 2021

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Background: Trigonella foenum-graecum L. (fenugreek) seeds have a long history of treating allergic asthma known as "Rabv" in Persian medicine. The protective effects of fenugreek on asthma have been noted in Persian medicine texts. Objective: The aim of the present study was to investigate the protective effects of aqueous fenugreek seed extract (AFSE) on the reduction of Th2 cytokines via decreasing the levels of mRNA expression of Th2 cytokines in bronchoalveolar lavage fluid (BALF). Methods: 28 female Balb/c mice were divided into four groups of seven animals. Negative and positive control groups received Phosphate-buffered saline and ovalbumin (OVA), respectively. The remaining two groups were firstly sensitized with OVA to induce asthma and then received Theophylline and AFSE. Thereafter, the mRNA expressions of Th2-type interleukins (IL-4, IL-5, and IL-13) and mucin5 as well as the concentrations of IL-5, IL-13, and IL-33 in BALF samples were measured and pathological alterations of lung tissues were analyzed. Results: AFSE treatment of Balb/c mice significantly decreased the number of eosinophils, the mRNA expressions of IL-4, IL-5, IL-13, and mucin5 and the concentrations of IL-5, IL-13, and IL-33 in their BALF specimens. It also considerably prevented peribronchial and perivascular inflammations, mucus hypersecretion, and goblet cell hyperplasia in lung tissues in comparison to OVA-sensitized mice. Conclusion: The present study demonstrated that the aqueous fenugreek seeds extract could be an alternative medication for the treatment of allergic asthma.

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