Effect of neuron‐derived neurotrophic factor on rejuvenation of human adipose‐derived stem cells for cardiac repair after myocardial infarction

Yang, Kun; Song, Hui‐Fang; He, Sheng; Wu, Yin; Fan, Xuemei; Ren, Feng; Gong, Hui; Zhai, Xiaoyan; Zhang, Jie; Peng, Zexu; Xi, Guangxia; Xie, Jun; Li, Ren‐Ke

doi:10.1111/jcmm.14456

Cited by 12 publications

(6 citation statements)

References 35 publications

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“…ADSCs are redundant and can be harvested from adipose tissues (Hong et al, 2019). ADSCs and their exosomes represent new approaches for myocardial repair (Perea-Gil et al, 2018;Bai et al, 2019;Yang et al, 2019). Cardiosphere-derived cells (CDCs) are cardiac progenitor cells with anti-inflammatory, anti-oxidant, anti-fibrotic, and cardiomyogenic properties (Gallet et al, 2017;Marban, 2018).…”

Section: Exosomes From Stem Cellsmentioning

confidence: 99%

Utilization of Human Induced Pluripotent Stem Cells for Cardiac Repair

Fan

Zhang

Joshi

et al. 2020

Front. Cell Dev. Biol.

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The paracrine effect, mediated by chemical signals that induce a physiological response on neighboring cells in the same tissue, is an important regenerative mechanism for stem cell-based therapy. Exosomes are cell-secreted nanovesicles (50-120 nm) of endosomal origin, and have been demonstrated to be a major contributor to the observed stem cell-mediated paracrine effect in the cardiac repair process. Following cardiac injury, exosomes deriving from exogenous stem cells have been shown to regulate cell apoptosis, proliferation, angiogenesis, and fibrosis in the infarcted heart. Exosomes also play a crucial role in the intercellular communication between donor and recipient cells. Human induced pluripotent stem cells (hiPSCs) are promising cell sources for autologous cell therapy in regenerative medicine. Here, we review recent advances in the field of progenitor-cell derived, exosome-based cardiac repair, with special emphasis on exosomes derived from hiPSCs.

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Section: Exosomes From Stem Cellsmentioning

confidence: 99%

Utilization of Human Induced Pluripotent Stem Cells for Cardiac Repair

Fan

Zhang

Joshi

et al. 2020

Front. Cell Dev. Biol.

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“…Stem cell antigen 1 (Sca-1)+ MSCs resident in the heart increase angiogenesis, and activate cell proliferation in the infarcted heart, which improves cardiac function after MI[ 123 , 124 ]. Overexpression of neuron-derived neurotrophic factor rejuvenates human ADSCs and BM-MSCs from the elderly, reduces the ischemic area, and repairs cardiac function after MI by improving angiogenesis and decreasing apoptosis[ 125 , 126 ]. Ethyl pyruvate, a HMGB1 inhibitor, restores the senescent phenotype of BM-MSCs, alleviates clinical signs of lupus nephritis, and prolongs survival of MRL/Mp-lpr/lpr mice via TLR4-NF-kappaB signaling[ 127 ].…”

Section: Cellular Rejuvenation Strategiesmentioning

confidence: 99%

Senescent mesenchymal stem/stromal cells and restoring their cellular functions

Meng¹,

Liu²,

Lu³

et al. 2020

WJSC

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Mesenchymal stem/stromal cells (MSCs) have various properties that make them promising candidates for stem cell-based therapies in clinical settings. These include self-renewal, multilineage differentiation, and immunoregulation. However, recent studies have confirmed that aging is a vital factor that limits their function and therapeutic properties as standardized clinical products. Understanding the features of senescence and exploration of cell rejuvenation methods are necessary to develop effective strategies that can overcome the shortage and instability of MSCs. This review will summarize the current knowledge on characteristics and functional changes of aged MSCs. Additionally, it will highlight cell rejuvenation strategies such as molecular regulation, non-coding RNA modifications, and microenvironment controls that may enhance the therapeutic potential of MSCs in clinical settings.

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“… 3 Preclinical studies conducted over the past 2 decades have evaluated the regenerative potential of multiple cell types. These include myoblasts, 4 , 5 , 6 bone marrow (BM) mononuclear cells, 7 , 8 mesenchymal stem cells (MSCs), 9 , 10 and endogenous cardiac progenitors, such as c-kit + cardiac progenitor cells (CPCs), 11 sca1 + CPCs, 12 and cardiosphere-derived cells, 13 as well as embryonic stem cells (ESCs) 14 , 15 and induced pluripotent stem cell (iPSC)-induced cardiomyocytes (CMs). 16 , 17 Decreased myocardial fibrosis, neovascularization, prevention of left-ventricle (LV) dilation, and enhancement of local cardiac contractility have been successively described for stem cells of different origins, 18 , 19 , 20 leading to rapid progression to clinical trials for a subset of these cell types.…”

Section: Introductionmentioning

confidence: 99%

Human MuStem Cell Grafting into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function

Rannou

Toumaniantz

Larcher

et al. 2020

Molecular Therapy - Methods & Clinical Development

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Myocardial infarction is one of the leading causes of mortality and morbidity worldwide. Whereas transplantation of several cell types into the infarcted heart has produced promising preclinical results, clinical studies using analogous human cells have shown limited structural and functional benefits. In dogs and humans, we have described a type of muscle-derived stem cells termed MuStem cells that efficiently promoted repair of injured skeletal muscle. Enhanced survival rate, long-term engraftment, and participation in muscle fiber formation were reported, leading to persistent tissue remodeling and clinical benefits. With the consideration of these features that are restricted or absent in cells tested so far for myocardial infarction, we wanted to investigate the capacity of human MuStem cells to repair infarcted hearts. Their local administration in immunodeficient rats 1 week after induced infarction resulted in reduced fibrosis and increased angiogenesis 3 weeks post-transplantation. Importantly, foci of human fibers were detected in the infarct site. Treated rats also showed attenuated left-ventricle dilation and preservation of contractile function. Interestingly, no spontaneous arrhythmias were observed. Our findings support the potential of MuStem cells, which have already been proposed as therapeutic candidates for dystrophic patients, to treat myocardial infarction and position them as an attractive tool for muscle-regenerative medicine.

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Effect of neuron‐derived neurotrophic factor on rejuvenation of human adipose‐derived stem cells for cardiac repair after myocardial infarction

Cited by 12 publications

References 35 publications

Utilization of Human Induced Pluripotent Stem Cells for Cardiac Repair

Utilization of Human Induced Pluripotent Stem Cells for Cardiac Repair

Senescent mesenchymal stem/stromal cells and restoring their cellular functions

Human MuStem Cell Grafting into Infarcted Rat Heart Attenuates Adverse Tissue Remodeling and Preserves Cardiac Function

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