Effect of Neuropeptide Y on Action Potential Generation in Working Cardiomyocytes of the Right Atrium in Rat Heart

Abstract

We studied the effect of neuropeptide Y in concentrations of 10-10 M on electrical activity of adult rat right atrial cardiomyocytes with preserved spontaneous activity. Neuropeptide Y was found to modulate the amplitude-time parameters of action potential: in concentrations of 10 and 10 M it reduced the membrane potential, increased the amplitude of action potential and duration of the repolarization phase, and reduced the frequency of action potential generation. In concentration of 10 M, neuropeptide Y produced stronger effect on the analyzed parameters, while in concentration of 10 M it produced no significant changes.