Effect of nicotine on quinpirole-induced checking behavior in rats: implications for obsessive-compulsive disorder

Effects of nicotine on quinpirole- and dizocilpine (MK-801)-induced sensorimotor gating impairments in rats

“…However, sensorimotor impairments induced by QNP were attenuated or blocked by nicotine. This effect of nicotine is consistent with its other observed effects against QNP including amelioration of QNP-included compulsive-like behavior in rats (Tizabi et al 1999a(Tizabi et al , 2002. The effects of nicotine on QNP-induced PPI reductions in rats are similar to that of haloperidol, a clinically used antipsychotic (Caine et al Fig.…”

Effects of the serotonergic agonist mCPP on male rats in the quinpirole sensitization model of obsessive–compulsive disorder (OCD)

“…Finally, treatments that are therapeutically useful for OCD are also effective in attenuating quinpirole-induced compulsive checking, e.g., clomipramine (Foa et al 2005;Szechtman et al 1998), nicotine (Lundberg et al 2004;Salin-Pascual and Basanez-Villa 2003;Tizabi et al 2002), and deep brain stimulation (Djodari-Irani et al 2011;Greenberg et al 2006;Mundt et al 2009;Winter et al 2008).…”

Kappa-Opioid Agonist U69593 Potentiates Locomotor Sensitization to the D2/D3 Agonist Quinpirole: Pre- and Postsynaptic Mechanisms

“…Behavioral sensitization is of much interest because of its potential relevance to several human pathologies ranging from drug addiction to schizophrenia (Kalivas and Stewart, 1991;Koob and Le Moal, 1997;Robinson and Becker, 1986;Segal and Schuckit, 1983) and obsessive-compulsive disorder (Eilam and Szechtman, 2005;Szechtman et al, 1998Szechtman et al, , 2001Tizabi et al, 2002). Responses that sensitize with chronic drug treatment may include locomotion, sniffing, licking, or biting.…”