Effect of nifedipine on gingival enlargement and periodontal breakdown in ligature-induced periodontitis in rats

Fernandes, Marilene Issa; Gaio, Eduardo José; Susin, Cristiano; Rösing, Cassiano Kuchenbecker; Oppermann, Rui Vicente; Rados, Pantelis Varvaki

doi:10.1016/j.archoralbio.2010.05.003

Cited by 14 publications

(9 citation statements)

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“…It might be due to different size of sample or different related prescribed doses. On the other hand, we emphasize that although amlodipine shows great GE prevalence when used in combination with CsA, this combination displays lower GE prevalence and severity than that revealed in CsA-nifedipine combination (2, 6). In addition, other risk factors were not significantly effective on periodontal lesions in the current study.…”

Section: Discussionmentioning

confidence: 60%

“…Drug induced GE is a clinical condition characterized by an increase in the size of gingival tissues leading to an alteration in gingival contour (6). It could be the side effect of several drugs such as anticonvulsants, immunosuppressive agents, and calcium channel blockers (7).…”

Section: Introductionmentioning

confidence: 99%

“…It could be the side effect of several drugs such as anticonvulsants, immunosuppressive agents, and calcium channel blockers (7). Gingival enlargement is considered as the most common periodontal side effect of amlodipine (6). On the other hand, incidence of GE in renal transplant recipients maintained on CsA varies from 13 to 84.6% (1, 8, 9).…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Amlodipine on Gingival Enlargement After Kidney Transplantation

Rahimi

Einollahi

et al. 2012

Nephro Urol Mon

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Background: Although cyclosporine (CsA) and calcium channel blockers (CCBs) parallel to each other may provoke gingival enlargement (GE), there are few considerations about combined effects of CsA and CCBs on gingival tissues.Objectives: This study aimed to determine prevalence of GE among renal transplant recipients and to compare its occurrence in patients who received only CsA and those who were on CsA and amlodipine.Patients and Methods: We conducted a prospective randomized case-control trial including 213 renal transplant recipients between February 2010 and August 2010. They were randomly divided into two groups including control group (on continuous treatment with CsA alone; n = 112) and trial group (treated with combined CsA and amlodipine; n = 101). Buccal, lingual, and inter-proximal membranes at last 12 anterior teeth were assessed for GE and packet depth (PD) using Gingival Index of McGaw and others, and Packet Index of Turesky–Gilmore–Glickman, respectively.Results: Marked GE was observed in 26 patients (25.7%) in trial group and only in 4 individuals (3.6%) in control group (P = 0.000). In logistic regression analysis, obese (OR = 3, P = 0.04), older (OR = 2.8, P = 0.03), and female (OR = 1.3, P = 0.03) recipients as well as who received high dose amlodipine (OR = 4.4, P = 0.000) were at risk for marked GE.Conclusions: There is a strong correlation between GE, in particular marked GE, and combination therapy with CsA and amlodipine in transplant patients compared to those treated by CsA alone. We suggest CsA dose reduction may restrain this adverse effect.

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Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Impact of Amlodipine on Gingival Enlargement After Kidney Transplantation

Rahimi

Einollahi

et al. 2012

Nephro Urol Mon

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“…Según diversas investigaciones 18,19,20,21 , la inflamación gingival provocada por el acumulo de placa bacteriana es un factor muy importante para la aparición y severidad del agrandamiento gingival. En nuestro estudio, al realizar el llenado del periodontograma pudimos observar la presencia o ausencia de inflamación, pero no fue posible correlacionar estas variables con seguridad ya que se realizó de forma transversal.…”

Section: Discussionunclassified

Agrandamiento gingival por bloqueantes de canales de calcio

Diestra

Linares

2014

Odontol. sanmarquina

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IntroducciónEn la actualidad, la hipertensión arterial es una enfermedad frecuente y, en muchas ocaciones, es controlada con diversos fármacos, entre los cuales tenemos: Betabloqueadores (atenolol, metropolol), inhibidores ECA (captopril, enalapril), inhibidores de angiotensina II (candesartan, valsartan), bloqueantes de canales de calcio (nifedipina, amlodipina, diltiazem), entre otros.1 El uso de fármacos bloqueantes de canales de calcio, ya que son útiles para el tratamiento de diversas patologías cardiacas e hipertensión 2,3; sin embargo, como efecto secundario, pueden provocar agrandamiento gingival, el cual se ha reportado también por el consumo de ciclosporina y fenitoína.Este aumento del volumen gingival produce problemas, no solo estéticos, sino también dificultades para el cepillado dental, lo cual agrava la condición periodontal. En algunos casos, puede ocasionar problemas funcionales, ya que, si el aumento es severo, dificulta la masticación4El agrandamiento gingival (AG) tiene diversas etiologías que pueden estar relacionadas a condiciones sistémicas patológicas (leucemia, tumores, etc.) o fisiológicas (alteraciones hormonales durante la pubertad, embarazo, menopausia)4,5, pero en el caso del agrandamiento inducido por fármacos, se manifiesta solo en algunas personas con ciertos factores de riesgo, que pueden ser el consumo de dosis altas del fárma-co, factores demográficos (edad y géne-ro) e influencia de la higiene dental 3,2 .El objetivo del presente estudio fue determinar la frecuencia del agrandamiento gingival por bloqueantes de canales de calcio y evaluar su relación Agrandamiento gingival por bloqueantes de canales de calcioGingival overgrowth by calcium channel blockers ResumenObjetivo: Determinar la frecuencia del agrandamiento gingival en pacientes hipertensos que consumen fármacos bloqueantes de canales de calcio y compararlo con otro grupo de pacientes hipertensos que no consumen dichos fármacos. Métodos: En el estudio descriptivo transversal se evaluaron a 50 pacientes hipertensos que consumían bloqueantes de canales de calcio (grupo de estudio) y a 50 pacientes hipertensos que recibían tratamiento con otro tipo de antihipertensivos (grupo control). Se les realizó una ficha de recolección de datos, periodontograma y fotografías de las lesiones por agrandamiento gingival. Resultados: Se halló que el 10% de los pacientes que consumían bloqueantes de canales de calcio presentaron agrandamiento gingival, lo cual fue estadísticamente significativo (p<0.05), en el grupo control no se halló agrandamiento gingival. Hubo una tendencia inversa con respecto a la edad, ya que mientras aumentaba la edad, disminuía la frecuencia de agrandamiento gingival, pero no se halló relación estadísticamente significativa. Conclusiones: El 10% de pacientes que usan antihipertensivos bloqueantes de canales de calcio presentaron agrandamiento gingival, lo cual fue estadísticamente significativo en relación al grupo control. El género, la edad y la arcada afectada no están relacionados con el agrandamiento gingiv...

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“…The exact mechanism of induction is unclear, although several studies suggest that resident fibroblasts produce more collagen and other extracellular matrix molecules than normal [2]. More recently, studies have shown that the epithelial thickness encountered in gingival overgrowth could be associated with an increase in the mitotic activity of the epithelium, as measured by the expression of proliferation markers [3]; in rats, nifedipine itself did not lead to gingival enlargement, but in the presence of biofilm accumulation, nifedipine yielded greater gingival enlargement and periodontal inflammation, however there was no increase in periodontal destruction [4].…”

Section: Introductionmentioning

confidence: 99%

Nifedipine-Induced gingival overgrowth

Florio¹,

Tfouni²,

Balducci³

et al. 2013

BDS

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Objective: The objective of the present study was to evaluate gingival overgrowth induced by nifedipine and to correlate it with plaque accumulation. Material and Methods: Sixty patients were divided into a treated group (n=30) consisting of hypertensive patients long-term treated with nifedipine and a control group (n=30) consisting of patients without arterial visit: anamnesis, measurement of blood pressure, weight and height, extra-and intraoral examination, and determination of the vertical and horizontal gingival overgrowth indices, plaque index, and bleeding index. The measurements were repeated after 30 days. Results: Most patients using nifedipine (60.7%) presented grade I horizontal gingival overgrowth (1 to 2 mm), with 3.6% showing minimum vertical gingival overgrowth. On the return visit, the plaque index was reduced by 8.3% and bleeding on probing was reduced by 1.5%. The individuals of control group, presented neither vertical gingival overgrowth nor horizontal, the plaque index was reduced by 7.2% and bleeding horizontal gingival overgrowth index was observed between the treated and control groups (chi-square test, p = 0.015, p < 0.05). Conclusions: In the present study, authors conclude that degree of gingival overgrowth in patients using nifedipine.

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Effect of nifedipine on gingival enlargement and periodontal breakdown in ligature-induced periodontitis in rats

Abstract: Nifedipine itself did not lead to gingival enlargement in rats. In the presence of biofilm accumulation, nifedipine yielded greater gingival enlargement and periodontal inflammation, but it did not increase periodontal destruction.

Cited by 14 publications

References 26 publications

The Impact of Amlodipine on Gingival Enlargement After Kidney Transplantation

The Impact of Amlodipine on Gingival Enlargement After Kidney Transplantation

Agrandamiento gingival por bloqueantes de canales de calcio

Nifedipine-Induced gingival overgrowth

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