Effect of nifedipine treatment on oxidative metabolism of peritoneal macrophages and neutrophils of Plasmodium berghei-infected mice

Kalra, Amit; Dubey, M L; Ganguly, Nirmal Kumar; Mohan, Kanwar; Mahajan, Rohit

doi:10.1016/0014-4894(92)90135-w

Cited by 4 publications

(3 citation statements)

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“…berghei infection after initial enhancement leads to the inhibition of oxygen metabolite-producing capacity of phagocytes as evidenced by chemiluminescence (CL) response. One of our studies aimed at exploring altered immune reactivity of murine peritoneal macrophages and neutrophils to malaria parasites following treatment with nifedipine also revealed a biphasic CL response with significant reduction in cell activation potential (Kalra et al 1992). These observations suggest that phagocytic cells are under the influence of CCB which inhibit their normal functions to a certain extent.…”

Section: Discussionmentioning

confidence: 83%

Altered course ofPlasmodium bergheiinfection by nifedipine treatment

Kalra

Dubey

Ganguly

et al. 1993

Apmis

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The effect of nifedipine (a calcium channel blocker) on the course of P. berghei infection was examined. It was observed that mice receiving a daily dose of 0.015 mg/kg of nifedipine had significantly shorter prepatent, patent and survival periods as compared to untreated P. berghei‐infected animals (p < 0.001). This shows that the calcium channel blockers, in addition to possessing the property of reversing drug resistance during combined therapy with chloroquine, may also alter the pathophysiology of malaria infection. The decreased resistance of the host to the invading parasite suggests that the effect of CCB on the host‐parasite interaction in human malaria needs to be investigated further before CCB can be used in combination with chloroquine for the treatment of chloroquine‐resistant malaria or for chemoprophylaxis.

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Section: Discussionmentioning

confidence: 83%

Altered course ofPlasmodium bergheiinfection by nifedipine treatment

Kalra

Dubey

Ganguly

et al. 1993

Apmis

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“…Unlike f? berghei infection of mice, where intermediate level of parasitaemia (5-10%) resulted in high CL response (Kalra et al 1992), acute I? knowlesi infection showed the highest oxidative burst at the peak of infection (7040% parasi taemia).…”

Section: Discussionmentioning

confidence: 99%

Generation of reactive oxygen species by blood monocytes during acutePlasmodium knowlesiinfection in rhesus monkeys

Jayshree

Ganguli

Dubey

et al. 1993

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The status and kinetics of monocyte activation during acute P. knowlesi infection was investigated by latex‐induced, luminol‐dependent chemiluminescence (CL) response. The contribution of various reactive oxygen species (ROS) to CL response was estimated before infection and at peak parasitaemia (day 7 post infection) by using scavengers of ROS (benzoate, catalase and superoxide dismutase). The chemiluminescence index (CLI) was not found to be significantly different from controls on day 2 postinfection, but was significantly higher on days 5 and 7 postinfection. Hydroxyl radical (OH·) production was considerably elevated, whereas superoxide anion(O2−·) and hydrogen peroxide (H2O2) production dropped following infection. These changes in generation of ROS are discussed in relation to the progression of parasitaemia to high levels, immunopathology and immunosuppression during acute P. knowlesi infection.

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“…In conclusion, based on the results of ongoing /completed ( Table 2 , Table 3 ) clinical trials (151 trials) stringent parameters need to be considered to further support the usage of CQ and HCQ in COVID-19 patients. Our laboratory is actively engaged in elucidating the molecular pathways of therapeutic modalities used in malaria [ 62 , [112] , [113] , [114] , [115] ]. The effective nanoformulations of HCQ/CQ can help in reducing the side-effects of these wonder cost effective drugs for use in future dose-dosage regimens for COVID-19.…”

Section: Old Bullets For New Target: Drugs For Mitigating the Symptommentioning

confidence: 99%